Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells

(2021) Anne Slomp et al.   Cell Death & Disease

Saga of Mcl-1: regulation from transcription to degradation

(2020) Viacheslav V. Senichkin et al.   CELL DEATH AND DIFFERENTIATION

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

(2020) Yang Gao et al.   NATURE CELL BIOLOGY

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer

(2019) Xiaowei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JOSD1 inhibits mitochondrial apoptotic signalling to drive acquired chemoresistance in gynaecological cancer by stabilizing MCL1

(2019) Xiaowei Wu et al.   CELL DEATH AND DIFFERENTIATION

Functional analysis of deubiquitylating enzymes in tumorigenesis and development

(2019) Ji Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis

(2018) Seiji Arai et al.   CLINICAL CANCER RESEARCH

Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MCL-1 is a prognostic indicator and drug target in breast cancer

(2018) Kirsteen J. Campbell et al.   Cell Death & Disease

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

(2018) Shengzhe Zhang et al.   Nature Communications

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

(2018) Delphine Merino et al.   CANCER CELL

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

(2017) Loren M. Lasko et al.   NATURE

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function

(2017) Naoe T. Nihira et al.   Science Signaling

Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory

(2017) Guan Wang et al.   Cell Reports

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function

(2017) Naoe T. Nihira et al.   Science Signaling

Sirtuin 3: A Janus face in cancer (Review)

(2016) Yanlu Xiong et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer

(2016) Narsis Attar et al.   Cold Spring Harbor Perspectives in Medicine

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor

(2015) Y. Xiao et al.   MOLECULAR CANCER THERAPEUTICS

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1

(2014) Richard G. Carroll et al.   Cell Reports

Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein

(2014) Barbara Mojsa et al.   Cells

Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition

(2013) Feng Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Programming cancer cells for high expression levels of Mcl1

(2013) Franziska Ertel et al.   EMBO REPORTS

CPLM: a database of protein lysine modifications

(2013) Zexian Liu et al.   NUCLEIC ACIDS RESEARCH

Acetylation-Dependent Regulation of Skp2 Function

(2012) Hiroyuki Inuzuka et al.   CELL

Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons

(2012) M M Magiera et al.   CELL DEATH AND DIFFERENTIATION

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

(2012) S. P. Glaser et al.   GENES & DEVELOPMENT

Histone deacetylases and cancer

(2012) Bruna Barneda-Zahonero et al.   Molecular Oncology

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

(2011) Daming Gao et al.   MOLECULAR CELL

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination

(2011) H Li et al.   ONCOGENE

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity

(2011) R. Dash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

Mcl-1; the molecular regulation of protein function

(2010) Luke W. Thomas et al.   FEBS LETTERS

Transcriptional Synergy between Melanoma Antigen Gene Protein-A11 (MAGE-11) and p300 in Androgen Receptor Signaling

(2010) Emily B. Askew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

(2010) Zhifu Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

HDACi – Targets beyond chromatin

(2009) Marc Buchwald et al.   CANCER LETTERS

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Control of mitochondrial apoptosis by the Bcl-2 family

(2009) J. K. Brunelle et al.   JOURNAL OF CELL SCIENCE

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

mTORC1 promotes survival through translational control of Mcl-1

(2008) J. R. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA