Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein

A role of PIEZO1 in iron metabolism in mice and humans

(2021) Shang Ma et al.   CELL

Parkinson’s Disease: Alterations in Iron and Redox Biology as a Key to Unlock Therapeutic Strategies

(2021) L. Ma et al.   Redox Biology

Conservative iron chelation for neurodegenerative diseases such as Parkinson’s disease and amyotrophic lateral sclerosis

(2020) David Devos et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroinflammation and Glial Phenotypic Changes in Alpha-Synucleinopathies

(2019) Violetta Refolo et al.   Frontiers in Cellular Neuroscience

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species

(2018) Angeliki M. Andrianaki et al.   Nature Communications

Anemia of inflammation

(2018) Guenter Weiss et al.   BLOOD

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer’s Disease

(2017) Zohara Sternberg et al.   Aging and Disease

Iron Withholding: A Defense Against Disease

(2017) Eugene D. Weinberg et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

Brain Iron Metabolism Dysfunction in Parkinson’s Disease

(2016) Hong Jiang et al.   MOLECULAR NEUROBIOLOGY

Pathophysiology of Motor Dysfunction in Parkinson’s Disease as the Rationale for Drug Treatment and Rehabilitation

(2016) Francesca Magrinelli et al.   Parkinsons Disease

The Iron age of host-microbe interactions

(2015) M. P. Soares et al.   EMBO REPORTS

Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex

(2015) Marine Lacroix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone

(2015) Liangliang Zhao et al.   JOURNAL OF NEUROCHEMISTRY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron in Infection and Immunity

(2013) James E. Cassat et al.   Cell Host & Microbe

Pathogenesis of Parkinson's disease

(2012) Etienne C. Hirsch et al.   MOVEMENT DISORDERS

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

(2012) Justin Y. Kwan et al.   PLoS One

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron Out-of-Balance: A Risk Factor for Acute and Chronic Diseases

(2008) Eugene D. Weinberg   HEMOGLOBIN