Catalytic Arylboration of Spirocyclic Cyclobutenes: Rapid Access to Highly Substituted Spiro[3.n]alkanes

Mechanism-Based Design of an Amide-Directed Ni-Catalyzed Arylboration of Cyclopentene Derivatives

(2021) Alison L. Lambright et al.   ORGANIC LETTERS

Stereoselective diboration of spirocyclobutenes: a platform for the synthesis of spirocycles with orthogonal exit vectors

(2021) Luis Nóvoa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel‐Catalyzed Regioselective Arylboration of Conjugated Dienes

(2021) Haoyang Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2-Oxaspiro[3.3]heptanes

(2021) Philip R. D. Murray et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

1,2-Arylboration of aliphatic alkenes by cooperative palladium/copper catalysis

(2021) Kazuhiko Semba et al.   TETRAHEDRON LETTERS

A catalytic asymmetric cross-coupling approach to the synthesis of cyclobutanes

(2021) F. Wieland Goetzke et al.   Nature Chemistry

Regioselective Monoborylation of Spirocyclobutenes

(2021) Luis Nóvoa et al.   ORGANIC LETTERS

Fsp3: A new parameter for drug-likeness

(2020) Wenxiu Wei et al.   DRUG DISCOVERY TODAY

Beyond Carbon: Enantioselective and Enantiospecific Reactions with Catalytically Generated Boryl- and Silylcopper Intermediates

(2020) Weichao Xue et al.   ACS Central Science

Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon

(2020) Tanaji T. Talele   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Catalyzed Borylative Difunctionalization of π-Systems

(2020) Andrew Whyte et al.   ACS Catalysis

Spirocyclic Scaffolds in Medicinal Chemistry

(2020) Kerstin Hiesinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Bisheteroarylalkanes by Heteroarylboration: Development and Application of a Pyridylidene-Copper Complex

(2019) Yuan Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Streamlined Synthesis of C(sp3)-Rich N-Heterospirocycles Enabled by Visible-Light-Mediated Photocatalysis

(2019) Nils J. Flodén et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed 1,2-Arylboration of Vinylarenes

(2019) Wang Wang et al.   ORGANIC LETTERS

Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions

(2019) Liang-An Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ni-Catalyzed Arylboration of Unactivated Alkenes: Scope and Mechanistic Studies

(2019) Stephen R. Sardini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regioselective Arylboration of 1,3‐Butadiene

(2019) Allison M. Bergmann et al.   ISRAEL JOURNAL OF CHEMISTRY

Enantioselective Synthesis of Multisubstituted Allenes by Cooperative Cu/Pd-Catalyzed 1,4-Arylboration of 1,3-Enynes

(2019) Yang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Construction of Strained Spiro[2,3]hexanes through a Michael Addition/Ring Expansion/Cyclization Cascade

(2019) Chuan-Gang Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Intermolecular [2+2] Photocycloaddition Reaction of Cyclic Enones and Its Application in a Synthesis of (−)-Grandisol

(2018) Saner Poplata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Borylative Ring Closing C–C Coupling toward Spiro- and Dispiroheterocycles

(2018) Jordi Royes et al.   ACS Catalysis

Catalyst-Controlled 1,2- and 1,1-Arylboration of α-Alkyl Alkenyl Arenes

(2018) Allison M. Bergmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cross-coupling reactions by cooperative Pd/Cu or Ni/Cu catalysis based on the catalytic generation of organocopper nucleophiles

(2018) Kazuhiko Semba et al.   TETRAHEDRON

Nickel-Catalyzed Stereoselective Arylboration of Unactivated Alkenes

(2017) Kaitlyn M. Logan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regioselective Arylboration of Isoprene and Its Derivatives by Pd/Cu Cooperative Catalysis

(2017) Kevin B. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalyst Controlled Regiodivergent Arylboration of Dienes

(2017) Stephen R. Sardini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

50 Years of Zweifel Olefination: A Transition-Metal-Free Coupling

(2017) Varinder Aggarwal et al.   SYNTHESIS-STUTTGART

Modular Synthesis of Enantioenriched 1,1,2-Triarylethanes by an Enantioselective Arylboration and Cross-Coupling Sequence

(2017) Bin Chen et al.   ACS Catalysis

Catalytic Enantioselective Arylboration of Alkenylarenes

(2016) Kaitlyn M. Logan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The utilization of spirocyclic scaffolds in novel drug discovery

(2016) Ya-Jun Zheng et al.   Expert Opinion on Drug Discovery

Development of Enantiospecific Coupling of Secondary and Tertiary Boronic Esters with Aromatic Compounds

(2016) Marcin Odachowski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper/Palladium Synergistic Catalysis for thesyn- andanti-Selective Carboboration of Alkenes

(2015) Kaitlyn M. Logan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Enamine-Activation of Cyclopropanes for Highly Stereoselective Formation of Cyclobutanes

(2015) Kim Søholm Halskov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

(2014) Erick M. Carreira et al.   CHEMICAL REVIEWS

Alkene Carboboration Enabled by Synergistic Catalysis

(2014) Kevin B. Smith et al.   CHEMISTRY-A EUROPEAN JOURNAL

Arylboration of Alkenes by Cooperative Palladium/Copper Catalysis

(2014) Kazuhiko Semba et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Cyclobutanes through Organocatalytic Formal [2 + 2] Cycloadditions under H-Bond-Directing Dienamine Activation

(2014) Liang-Wen Qi et al.   ORGANIC LETTERS

Copper(I)-Catalyzed Borylative exo-Cyclization of Alkenyl Halides Containing Unactivated Double Bond

(2013) Koji Kubota et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and preparation of new palladium precatalysts for C–C and C–N cross-coupling reactions

(2012) Nicholas C. Bruno et al.   Chemical Science

Enantioselective methodologies for the synthesis of spiro compounds

(2011) Ramon Rios   CHEMICAL SOCIETY REVIEWS

Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

(2011) Johannes A. Burkhard et al.   ORGANIC LETTERS

Synthesis and Structural Analysis of a New Class of Azaspiro[3.3]heptanes as Building Blocks for Medicinal Chemistry

(2010) Johannes A. Burkhard et al.   ORGANIC LETTERS

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY