Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain

Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain

(2020) Fei Wang et al.   PAIN

Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain

(2019) Yuying Huang et al.   JOURNAL OF NEUROCHEMISTRY

Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain

(2018) Shafaq Sikandar et al.   BRAIN

The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions

(2018) Jinjun Chen et al.   Cell Reports

Catecholaminergic neurons in synaptic connections with pre-Bötzinger complex neurons in the rostral ventrolateral medulla in normoxic and daily acute intermittent hypoxic rats

(2017) Jun-Jun Kang et al.   EXPERIMENTAL NEUROLOGY

BDNF Contributes to Spinal Long-Term Potentiation and Mechanical Hypersensitivity Via Fyn-Mediated Phosphorylation of NMDA Receptor GluN2B Subunit at Tyrosine 1472 in Rats Following Spinal Nerve Ligation

(2017) Song Li et al.   NEUROCHEMICAL RESEARCH

Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

(2017) Therése Abrahamsson et al.   NEURON

Ionotropic glutamate receptors contribute to pain transmission and chronic pain

(2017) Min Zhuo   NEUROPHARMACOLOGY

Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity

(2017) Scott L Jones et al.   eLife

PresynapticN-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain

(2016) Jing-Dun Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

(2016) Nicholas L Weilinger et al.   NATURE NEUROSCIENCE

Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity

(2016) Abhishek Banerjee et al.   TRENDS IN NEUROSCIENCES

Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain

(2016) Franziska Denk et al.   Cell Reports

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing

(2016) Michael E. Hildebrand et al.   Cell Reports

BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation

(2015) Xu Ding et al.   NEUROBIOLOGY OF DISEASE

Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain

(2015) Kohei Koga et al.   NEURON

In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model

(2015) Lucia Hipólito et al.   PAIN

BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals

(2014) Wenling Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?

(2014) Jo Nijs et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP

(2014) Hyungju Park et al.   NEURON

BDNF: No gain without pain?

(2014) Peter A. Smith   NEUROSCIENCE

Synaptic plasticity in pathological pain

(2014) Ceng Luo et al.   TRENDS IN NEUROSCIENCES

Changes in synaptic efficacy in rat brain slices following extremely low-frequency magnetic field exposure at embryonic and early postnatal age

(2013) Tímea Balassa et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Dendritic SK channels convert NMDA-R-dependent LTD to burst timing-dependent plasticity

(2013) Erik Harvey-Girard et al.   JOURNAL OF NEUROPHYSIOLOGY

Loss of NR1 Subunit of NMDARs in Primary Sensory Neurons Leads to Hyperexcitability and Pain Hypersensitivity: Involvement of Ca2+-Activated Small Conductance Potassium Channels

(2013) P. Pagadala et al.   JOURNAL OF NEUROSCIENCE

Presynaptic NMDA Receptor Mechanisms for Enhancing Spontaneous Neurotransmitter Release

(2013) P. A. Kunz et al.   JOURNAL OF NEUROSCIENCE

Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain

(2013) Xisheng Yan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Presynaptic Self-Depression at Developing Neocortical Synapses

(2013) Antonio Rodríguez-Moreno et al.   NEURON

Non-Hebbian plasticity at C-fiber synapses in rat spinal cord lamina I neurons

(2013) Asami Naka et al.   PAIN

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

(2013) S. Nabavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced conduction failure of the main axon of polymodal nociceptive C-fibres contributes to painful diabetic neuropathy in rats

(2012) Wei Sun et al.   BRAIN

Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons

(2012) Xue-Hong Cao et al.   JOURNAL OF NEUROCHEMISTRY

Brain-derived neurotrophic factor modulates N-methyl-D-aspartate receptor activation in a rat model of cancer-induced bone pain

(2012) Li-Na Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Target-Specific Expression of Presynaptic NMDA Receptors in Neocortical Microcircuits

(2012) Katherine A. Buchanan et al.   NEURON

Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain

(2012) Tuan Trang et al.   Neuron Glia Biology

Small-Conductance Ca2+-Activated K+ Channels: Form and Function

(2011) John P. Adelman et al.   Annual Review of Physiology

Direct injection into the dorsal root ganglion: Technical, behavioral, and histological observations

(2011) Gregory Fischer et al.   JOURNAL OF NEUROSCIENCE METHODS

Presynaptic NMDA receptors also make the switch

(2011) Andrés Buonanno   NATURE NEUROSCIENCE

NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity

(2011) Rylan S Larsen et al.   NATURE NEUROSCIENCE

Kainate receptors coming of age: milestones of two decades of research

(2011) Anis Contractor et al.   TRENDS IN NEUROSCIENCES

Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation

(2010) Shan-Jing Geng et al.   EXPERIMENTAL NEUROLOGY

Opioid-Induced Long-Term Potentiation in the Spinal Cord Is a Presynaptic Event

(2010) H.-Y. Zhou et al.   JOURNAL OF NEUROSCIENCE

Presynaptic NMDARs in the Hippocampus Facilitate Transmitter Release at Theta Frequency

(2010) Lindsay McGuinness et al.   NEURON

Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala

(2010) R.-M. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Activity-Dependent Secretion of Brain-Derived Neurotrophic Factor from Axon and Dendrite

(2009) N. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

Models and Mechanisms of Hyperalgesia and Allodynia

(2009) Jürgen Sandkühler   PHYSIOLOGICAL REVIEWS

BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn

(2008) Li-Jun Zhou et al.   EXPERIMENTAL NEUROLOGY

Synapse-Specific Expression of Functional Presynaptic NMDA Receptors in Rat Somatosensory Cortex

(2008) D. J. Brasier et al.   JOURNAL OF NEUROSCIENCE

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

(2008) Xue Jun Liu et al.   NATURE MEDICINE

BDNF as a pain modulator

(2008) A MERIGHI et al.   PROGRESS IN NEUROBIOLOGY

Spinal N-methyl-d-aspartate receptors and nociception-evoked release of primary afferent substance P

(2007) A. Nazarian et al.   NEUROSCIENCE