Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-11-25
DOI
10.1038/s41467-021-27221-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles
- (2020) Jian-Guo Li et al. Molecular Neurodegeneration
- Axon micro-dissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons
- (2020) Joaquina Farias et al. RNA
- Mitochondrial protein biogenesis in the synapse is supported by local translation
- (2020) Bozena Kuzniewska et al. EMBO REPORTS
- Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
- (2020) Michael Briese et al. Acta Neuropathologica Communications
- A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration
- (2020) Pabitra K. Sahoo et al. CURRENT BIOLOGY
- C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy
- (2020) Casey N. Cook et al. Science Translational Medicine
- Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
- (2019) Jean-Michel Cioni et al. CELL
- Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity
- (2019) Vidhya Rangaraju et al. CELL
- Aggregation of the nucleic acid–binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation
- (2019) Youjun Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
- (2019) Joseph R. Klim et al. NATURE NEUROSCIENCE
- Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
- (2019) Ze’ev Melamed et al. NATURE NEUROSCIENCE
- Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model
- (2019) Ariel Ionescu et al. Cell Death & Disease
- Genetic Convergence Brings Clarity to the Enigmatic Red Line in ALS
- (2019) Casey Cook et al. NEURON
- RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
- (2019) Jacob R. Mann et al. NEURON
- Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
- (2019) Fatima Gasset-Rosa et al. NEURON
- Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments
- (2019) Anne-Sophie Hafner et al. SCIENCE
- Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
- (2019) Mark Y. Fang et al. NEURON
- RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
- (2019) Ya-Cheng Liao et al. CELL
- The human motor neuron axonal transcriptome is enriched for transcripts related to mitochondrial function and microtubule-based axonal transport
- (2018) Renata Maciel et al. EXPERIMENTAL NEUROLOGY
- miR126-5p down-regulation facilitates axon degeneration and NMJ disruption via a non-cell-autonomous mechanism in ALS
- (2018) Roy Maimon et al. JOURNAL OF NEUROSCIENCE
- Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
- (2018) Yong-Jie Zhang et al. NATURE MEDICINE
- Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy
- (2018) Krista J. Spiller et al. NATURE NEUROSCIENCE
- TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
- (2018) Ching-Chieh Chou et al. NATURE NEUROSCIENCE
- Locally translated mTOR controls axonal local translation in nerve injury
- (2018) Marco Terenzio et al. SCIENCE
- TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types
- (2018) Yousra Khalfallah et al. Scientific Reports
- Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration
- (2018) Pabitra K. Sahoo et al. Nature Communications
- Instant Clue: A Software Suite for Interactive Data Visualization and Analysis
- (2018) Hendrik Nolte et al. Scientific Reports
- ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS
- (2018) Jone López-Erauskin et al. NEURON
- Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons
- (2018) Tatsuya Osaki et al. Science Advances
- Patient-derived co-cultures for studying ALS
- (2018) Ariel Ionescu et al. Nature Biomedical Engineering
- Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice
- (2017) Eva So et al. HUMAN MOLECULAR GENETICS
- Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes
- (2017) Arianna Russo et al. HUMAN MOLECULAR GENETICS
- Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons
- (2017) Pallavi P. Gopal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamic Axonal Translation in Developing and Mature Visual Circuits
- (2016) Toshiaki Shigeoka et al. CELL
- Compartmental microfluidic system for studying muscle–neuron communication and neuromuscular junction maintenance
- (2016) Ariel Ionescu et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy
- (2016) K. J. Spiller et al. JOURNAL OF NEUROSCIENCE
- Decoding ALS: from genes to mechanism
- (2016) J. Paul Taylor et al. NATURE
- smiFISH and FISH-quant – a flexible single RNA detection approach with super-resolution capability
- (2016) Nikolay Tsanov et al. NUCLEIC ACIDS RESEARCH
- Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
- (2015) Adam K. Walker et al. ACTA NEUROPATHOLOGICA
- MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
- (2015) Sarah E. Calvo et al. NUCLEIC ACIDS RESEARCH
- TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
- (2015) J. P. Ling et al. SCIENCE
- Assessment of Serum Protein Dynamics by Native SILAC Flooding (SILflood)
- (2014) Hendrik Nolte et al. ANALYTICAL CHEMISTRY
- Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
- (2014) Nael H. Alami et al. NEURON
- Molecular analysis and biochemical classification of TDP-43 proteinopathy
- (2012) Hiroshi Tsuji et al. BRAIN
- The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth
- (2012) Claudia Fallini et al. HUMAN MOLECULAR GENETICS
- Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment
- (2011) Jürgen Cox et al. JOURNAL OF PROTEOME RESEARCH
- The “Dying-Back” Phenomenon of Motor Neurons in ALS
- (2010) Michal Dadon-Nachum et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
- (2010) S. J. Barmada et al. JOURNAL OF NEUROSCIENCE
- TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
- (2008) I.-Fan Wang et al. JOURNAL OF NEUROCHEMISTRY
- TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
- (2008) Edor Kabashi et al. NATURE GENETICS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now