Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7

IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection

(2021) Zhimin Jiang et al.   Nature Microbiology

PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells

(2020) Davide Massa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

(2020) Matteo Bosso et al.   PLoS Pathogens

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection

(2019) Philipp E. Merkl et al.   mBio

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

(2019) Dominik Hotter et al.   Cell Host & Microbe

Defective interferon priming and impaired antiviral responses in a patient with an IRF7 variant and severe influenza

(2019) Michelle M. Thomsen et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease

(2019) Aleksandra Antonczyk et al.   Frontiers in Immunology

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus

(2019) Liu Cao et al.   PLoS Pathogens

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells

(2018) Chun-Feng Yu et al.   JOURNAL OF IMMUNOLOGY

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression

(2017) Sreya Ghosh et al.   JOURNAL OF IMMUNOLOGY

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation

(2017) Gareth Brady et al.   JOURNAL OF VIROLOGY

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation

(2017) Marni S. Crow et al.   MOLECULAR & CELLULAR PROTEOMICS

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

(2017) K. L. Jønsson et al.   Nature Communications

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters

(2015) Irene Lo Cigno et al.   JOURNAL OF VIROLOGY

Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1

(2015) Tobias Hilbert et al.   MEDIATORS OF INFLAMMATION

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA

(2015) B. A. Diner et al.   Molecular Systems Biology

Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

(2015) M. J. Ciancanelli et al.   SCIENCE

Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity

(2015) David M. Knipe   VIROLOGY

An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo

(2015) Brandon J. Aubrey et al.   Cell Reports

The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease

(2014) Dympna J. Connolly et al.   BIOCHEMICAL PHARMACOLOGY

Interferon γ-inducible Protein (IFI) 16 Transcriptionally Regulates Type I Interferons and Other Interferon-stimulated Genes and Controls the Interferon Response to both DNA and RNA Viruses

(2014) Mikayla R. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

(2014) Sonal Khare et al.   NATURE IMMUNOLOGY

Bridging the Species Divide: Transgenic Mice Humanized for Type-I Interferon Response

(2014) Daniel Harari et al.   PLoS One

IRF-5 and NF-κB p50 co-regulate IFN-β and IL-6 expression in TLR9-stimulated human plasmacytoid dendritic cells

(2013) Folkert Steinhagen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

The interferon response to intracellular DNA: Why so many receptors?

(2013) Leonie Unterholzner   IMMUNOBIOLOGY

A Y2H-seq approach defines the human protein methyltransferase interactome

(2013) Mareike Weimann et al.   NATURE METHODS

Morbillivirus V Proteins Exhibit Multiple Mechanisms to Block Type 1 and Type 2 Interferon Signalling Pathways

(2013) Senthil K. Chinnakannan et al.   PLoS One

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

(2012) Grazia Rosaria Gariano et al.   PLoS Pathogens

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions

(2011) Boris Reizis et al.   Annual Review of Immunology

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Cytosolic DNA sensors regulating type I interferon induction

(2011) Sinead E. Keating et al.   TRENDS IN IMMUNOLOGY

Role for Myeloid Nuclear Differentiation Antigen in the Regulation of Neutrophil Apoptosis during Sepsis

(2010) Nasser Fotouhi-Ardakani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome

(2009) Kate Schroder et al.   CURRENT BIOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE