An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation

Uncoupling Protein 2 as a pathogenic determinant and therapeutic target in cardiovascular and metabolic diseases

(2021) Rosita Stanzione et al.   Current Neuropharmacology

Roles of Autophagy in Oxidative Stress

(2020) Hyeong Rok Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats

(2020) Carla L. Busceti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

UCP2 protect the heart from myocardial ischemia/reperfusion injury via induction of mitochondrial autophagy

(2019) Hui Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence

(2019) Maurizio Forte et al.   Autophagy

Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy

(2018) Pan Pan et al.   MOLECULES

Uncoupling Protein 2 in Cardiovascular Health and Disease

(2018) Xiao Yu Tian et al.   Frontiers in Physiology

UCP2-dependent improvement of mitochondrial dynamics protects against acute kidney injury

(2018) Nan Qin et al.   JOURNAL OF PATHOLOGY

A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines

(2017) Speranza Rubattu et al.   JOURNAL OF HYPERTENSION

Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases

(2017) Giorgia Pierelli et al.   Oxidative Medicine and Cellular Longevity

Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat

(2017) Speranza Rubattu et al.   Cell Death & Disease

Endothelial Uncoupling Protein 2 Regulates Mitophagy and Pulmonary Hypertension During Intermittent Hypoxia

(2015) M. Haslip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP

(2015) Speranza Rubattu et al.   JOURNAL OF HYPERTENSION

Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains

(2015) Speranza Rubattu et al.   Oncotarget

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

Pathogenesis of Target Organ Damage in Hypertension: Role of Mitochondrial Oxidative Stress

(2014) Speranza Rubattu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transgenic Overexpression of Uncoupling Protein 2 Attenuates Salt-Induced Vascular Dysfunction by Inhibition of Oxidative Stress

(2013) S. Ma et al.   AMERICAN JOURNAL OF HYPERTENSION

Activation of NADPH Oxidase 4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the Protein Kinase RNA-Activated-Like Endoplasmic Reticulum Kinase/Eukaryotic Initiation Factor 2α/Activating Transcription Factor 4 Pathway

(2013) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Deconvoluting the role of reactive oxygen species and autophagy in human diseases

(2013) Xin Wen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential Modulation of Uncoupling Protein 2 in Kidneys of Stroke-Prone Spontaneously Hypertensive Rats Under High-Salt/Low-Potassium Diet

(2013) Sara Di Castro et al.   HYPERTENSION

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Pharmacological Modulation of Autophagy During Cardiac Stress

(2012) Sebastiano Sciarretta et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Hypertensive Cardiovascular and Renal Disease and Target Organ Damage: Lessons from Animal Models

(2011) Dinko Susic et al.   CardioRenal Medicine

Uncoupling Protein 2 Ablation Exacerbates High-Salt Intake-Induced Vascular Dysfunction

(2010) S. Ma et al.   AMERICAN JOURNAL OF HYPERTENSION

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY