JAK-STAT Pathway: A Novel Target to Tackle Viral Infections

Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections

(2021) Rinky Raghuvanshi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dengue Virus Non-Structural Protein 5 as a Versatile, Multi-Functional Effector in Host–Pathogen Interactions

(2021) Priya Bhatnagar et al.   Frontiers in Cellular and Infection Microbiology

A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD–0903) in severe COVID-19

(2021) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Pseudorabies Virus DNA Polymerase Processivity Factor UL42 Inhibits Type I IFN Response by Preventing ISGF3-ISRE Interaction

(2021) Rui Zhang et al.   JOURNAL OF IMMUNOLOGY

Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy

(2021) Thanigaimalai Pillaiyar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia

(2021) Patrícia O. Guimarães et al.   NEW ENGLAND JOURNAL OF MEDICINE

Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19

(2021) Carmen Mirabelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial

(2021) Vincent C Marconi et al.   Lancet Respiratory Medicine

The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency

(2021) Lesley R. de Armas et al.   Frontiers in Immunology

Janus Kinase Inhibitors and Coronavirus Disease (COVID)-19: Rationale, Clinical Evidence and Safety Issues

(2021) Milo Gatti et al.   Pharmaceuticals

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

(2020) Peter Richardson et al.   LANCET

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

COVID-19: combining antiviral and anti-inflammatory treatments

(2020) Justin Stebbing et al.   LANCET INFECTIOUS DISEASES

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

COVID-19 cytokine storm: The anger of inflammation

(2020) Mehdi Mahmudpour et al.   CYTOKINE

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

(2020) Dandan Wu et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22

(2020) Mudan Zhang et al.   JOURNAL OF IMMUNOLOGY

Potential for jaktinib hydrochloride to treat cytokine storms in patients with COVID-19

(2020) Xianmin Meng et al.   BioScience Trends

SARS, MERS and COVID-19: clinical manifestations and organ-system complications: a mini review

(2020) Jad Gerges Harb et al.   Pathogens and Disease

Cytokine storm induced by SARS-CoV-2

(2020) Peipei Song et al.   CLINICA CHIMICA ACTA

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19

(2020) Xiuhong Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Filgotinib suppresses HIV-1–driven gene transcription by inhibiting HIV-1 splicing and T cell activation

(2020) Yang-Hui Jimmy Yeh et al.   JOURNAL OF CLINICAL INVESTIGATION

The Dynamic Interface of Viruses with STATs

(2020) Angela R. Harrison et al.   JOURNAL OF VIROLOGY

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

(2020) Andre C. Kalil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy, Toxicity, and Infectious Complications in Ruxolitinib-Treated Patients with Corticosteroid-Refractory Graft-versus-Host Disease after Hematopoietic Cell Transplantation

(2019) Sameem Abedin et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-α via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)–mediated induction of suppressor of cytokine signaling (SOCS)3

(2019) Orla Convery et al.   FASEB JOURNAL

HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response

(2019) Michael A. Joyce et al.   PLoS Pathogens

Risk of viral reactivation in patients with occult hepatitis B virus infection during ruxolitinib treatment

(2018) Harinder Gill et al.   ANNALS OF HEMATOLOGY

Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins

(2018) Daniel Sauter et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Herpes simplex virus 1 UL36USP antagonizes type I IFN-mediated antiviral innate immunity

(2018) Hui Yuan et al.   JOURNAL OF VIROLOGY

Host Immune Response to Influenza A Virus Infection

(2018) Xiaoyong Chen et al.   Frontiers in Immunology

HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction

(2018) Siobhan Gargan et al.   EBioMedicine

Anti-adult T‑cell leukemia/lymphoma activity of cerdulatinib, a dual SYK/JAK kinase inhibitor

(2018) Chie Ishikawa et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The molecular details of cytokine signalling via the JAK/STAT pathway

(2018) Rhiannon Morris et al.   PROTEIN SCIENCE

OUP accepted manuscript

(2018)   RHEUMATOLOGY

HIV blocks Type I IFN signaling through disruption of STAT1 phosphorylation

(2018) Nam V Nguyen et al.   Innate Immunity

Fatal ruxolitinib-related JC virus meningitis

(2017) Begoña Ballesta et al.   JOURNAL OF NEUROVIROLOGY

Involvement of herpes simplex virus type 1 UL13 protein kinase in induction of SOCS genes, the negative regulators of cytokine signaling

(2017) Yuka Sato et al.   MICROBIOLOGY AND IMMUNOLOGY

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Cytokine storms in infectious diseases

(2017) John R. Teijaro   Seminars in Immunopathology

Immune-mediated cytokine storm and its role in severe dengue

(2017) Anon Srikiatkhachorn et al.   Seminars in Immunopathology

Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and respiratory syndrome virus

(2017) Liping Yang et al.   VETERINARY MICROBIOLOGY

Hijacking of the Ubiquitin/Proteasome Pathway by the HIV Auxiliary Proteins

(2017) Tanja Seissler et al.   Viruses-Basel

Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors

(2017) Christina Gavegnano et al.   PLoS Pathogens

Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

(2017) Andrea Majoros et al.   Frontiers in Immunology

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Cytomegalovirus Retinitis in a Patient Who Received Ruxolitinib

(2016) Joanna von Hofsten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases

(2016) Fiona J. Sorrell et al.   STRUCTURE

Interplay between the virus and the ubiquitin–proteasome system: molecular mechanism of viral pathogenesis

(2016) Honglin Luo   Current Opinion in Virology

Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2

(2016) Jennifer H. Stuart et al.   PLoS Pathogens

Tuberculosis and other opportunistic infections in tofacitinib-treated patients with rheumatoid arthritis

(2015) K L Winthrop et al.   ANNALS OF THE RHEUMATIC DISEASES

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms

(2015) Marieke C. Verweij et al.   PLoS Pathogens

Suppression of Dual Specificity Phosphatase I Expression Inhibits Hepatitis C Virus Replication

(2015) Jung Eun Choi et al.   PLoS One

Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus ReactivationIn Vitro

(2014) Christina Gavegnano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The molecular regulation of Janus kinase (JAK) activation

(2014) Jeffrey J. Babon et al.   BIOCHEMICAL JOURNAL

Reactivation of herpes simplex virus infection in a patient undergoing ruxolitinib treatment

(2014) Lana X. Tong et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Rotavirus NSP1 Mediates Degradation of Interferon Regulatory Factors through Targeting of the Dimerization Domain

(2013) M. M. Arnold et al.   JOURNAL OF VIROLOGY

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells

(2011) J. Carlier et al.   BLOOD

Kaposi's Sarcoma-Associated Herpesvirus Infection of Endothelial Cells Inhibits Neutrophil Recruitment through an Interleukin-6-Dependent Mechanism: a New Paradigm for Viral Immune Evasion

(2011) L. M. Butler et al.   JOURNAL OF VIROLOGY

The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling

(2010) M. Laurent-Rolle et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus Interferes with the Amplification of IFNα Secretion by Activating Suppressor of Cytokine Signaling 3 in Primary Human Monocytes

(2010) François Michaud et al.   PLoS One

Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling

(2010) Danlin Jia et al.   PLoS One

Human Fatal Zaire Ebola Virus Infection Is Associated with an Aberrant Innate Immunity and with Massive Lymphocyte Apoptosis

(2010) Nadia Wauquier et al.   PLoS Neglected Tropical Diseases

Respiratory Syncytial Virus Impairs Macrophage IFN-α/β– and IFN-γ–Stimulated Transcription by Distinct Mechanisms

(2009) Albert P. Senft et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Co-ordinating innate and adaptive immunity to viral infection: mobility is the key

(2009) JEANETTE ERBO CHRISTENSEN et al.   APMIS

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

(2009) J. Ashour et al.   JOURNAL OF VIROLOGY

Vaccinia Virus Blocks Stat1-Dependent and Stat1-Independent Gene Expression Induced by Type I and Type II Interferons

(2008) Brandon A. Mann et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH