Filgotinib suppresses HIV-1–driven gene transcription by inhibiting HIV-1 splicing and T cell activation

Integrated assessment of viral transcription, antigen presentation, and CD8+ T cell function reveal multiple limitations of class I selective HDACi during HIV-1 latency reversal

(2020) Talia M. Mota et al.   JOURNAL OF VIROLOGY

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

(2020) Julia Bergild McBrien et al.   NATURE

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

(2020) Christopher C. Nixon et al.   NATURE

HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells

(2020) Yetao Wang et al.   NATURE IMMUNOLOGY

Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target

(2020) Runxia Liu et al.   Science Translational Medicine

BUD13 Promotes a Type I Interferon Response by Countering Intron Retention in Irf7

(2019) Luke Frankiw et al.   MOLECULAR CELL

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

(2019) Marilia Rita Pinzone et al.   Nature Communications

Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy

(2019) Kevin B. Einkauf et al.   JOURNAL OF CLINICAL INVESTIGATION

The Activation State of CD4 T Cells Alters Cellular Peptidase Activities, HIV Antigen Processing, and MHC Class I Presentation in a Sequence-Dependent Manner

(2019) Julie Boucau et al.   JOURNAL OF IMMUNOLOGY

Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy

(2019) Mark C. Genovese et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

HIV Rebound Is Predominantly Fueled by Genetically Identical Viral Expansions from Diverse Reservoirs

(2019) Marie-Angélique De Scheerder et al.   Cell Host & Microbe

Genome wide analysis of hnRNP binding to HIV-1 RNA reveals a key role for hnRNP H1 in alternative viral mRNA splicing

(2019) Sebla B. Kutluay et al.   JOURNAL OF VIROLOGY

CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration

(2019) Christopher L. Nobles et al.   JOURNAL OF CLINICAL INVESTIGATION

Vpr Targets TET2 for Degradation by CRL4 VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication

(2018) Lei Lv et al.   MOLECULAR CELL

HIV latency in isolated patient CD4 + T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing

(2018) Steven A. Yukl et al.   Science Translational Medicine

DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection

(2018) Spyridon Stavrou et al.   mBio

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir

(2018) Biswajit Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction

(2018) Hisashi Akiyama et al.   Nature Communications

Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active ankylosing spondylitis (TORTUGA): results from a randomised, placebo-controlled, phase 2 trial

(2018) Désirée van der Heijde et al.   LANCET

Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active psoriatic arthritis (EQUATOR): results from a randomised, placebo-controlled, phase 2 trial

(2018) Philip Mease et al.   LANCET

Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

(2018) Sean Matthew McCauley et al.   Nature Communications

Improved assays to measure and characterize the inducible HIV reservoir

(2018) Marta Massanella et al.   EBioMedicine

Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity

(2017) Alyssa R. Martin et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-controlled trial

(2017) Séverine Vermeire et al.   LANCET

HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells

(2017) Daniela Cesana et al.   Nature Communications

Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation

(2017) Alexander Zhyvoloup et al.   PLoS Pathogens

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy

(2017) Christine M. Fennessey et al.   PLoS Pathogens

Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors

(2017) Christina Gavegnano et al.   PLoS Pathogens

Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK-1 Inhibitor, After Short-Term Treatment of Rheumatoid Arthritis: Results of Two Randomized Phase IIa Trials

(2017) Frédéric Vanhoutte et al.   Arthritis & Rheumatology

Anti-proliferative therapy for HIV cure: a compound interest approach

(2017) Daniel B. Reeves et al.   Scientific Reports

Disease drivers of aging

(2016) Richard J. Hodes et al.   Annals of the New York Academy of Sciences

The mTOR Complex Controls HIV Latency

(2016) Emilie Besnard et al.   Cell Host & Microbe

Immunologic Biomarkers, Morbidity, and Mortality in Treated HIV Infection

(2016) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

Specific Inhibition of HIV Infection by the Action of Spironolactone in T Cells

(2016) Benoît Lacombe et al.   JOURNAL OF VIROLOGY

Global intron retention mediated gene regulation during CD4+T cell activation

(2016) Ting Ni et al.   NUCLEIC ACIDS RESEARCH

Correction: HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission

(2016) Mykola Pinkevych et al.   PLoS Pathogens

Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells

(2016) Gianluigi Lichinchi et al.   Nature Microbiology

CDK11 in TREX/THOC Regulates HIV mRNA 3′ End Processing

(2015) Vladimir Pak et al.   Cell Host & Microbe

Origin of Rebound Plasma HIV Includes Cells with Identical Proviruses That Are Transcriptionally Active before Stopping of Antiretroviral Therapy

(2015) Mary F. Kearney et al.   JOURNAL OF VIROLOGY

Gene activity in primary T cells infected with HIV89.6: intron retention and induction of genomic repeats

(2015) Scott Sherrill-Mix et al.   Retrovirology

BRCA1 functions as a novel transcriptional cofactor in HIV-1 infection

(2015) Irene Guendel et al.   Virology Journal

Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1

(2015) Daniel I. S. Rosenbloom et al.   Open Forum Infectious Diseases

Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus ReactivationIn Vitro

(2014) Christina Gavegnano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Widespread intron retention in mammals functionally tunes transcriptomes

(2014) Ulrich Braunschweig et al.   GENOME RESEARCH

Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells

(2014) Eduardo Pauls et al.   JOURNAL OF IMMUNOLOGY

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection

(2014) Kirston M. Barton et al.   PLoS One

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

(2014) F. Maldarelli et al.   SCIENCE

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides

(2013) G. M. Laird et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Novel PCR Assay for Quantification of HIV-1 RNA

(2013) L. Shan et al.   JOURNAL OF VIROLOGY

UPF1 Is Crucial for the Infectivity of Human Immunodeficiency Virus Type 1 Progeny Virions

(2013) A. K. P. Serquina et al.   JOURNAL OF VIROLOGY

RNA splicing regulates the temporal order of TNF-induced gene expression

(2013) S. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Digoxin Suppresses HIV-1 Replication by Altering Viral RNA Processing

(2013) Raymond W. Wong et al.   PLoS Pathogens

Immunologic Basis of Cardiovascular Disease in HIV-Infected Adults

(2012) Priscilla Y. Hsue et al.   JOURNAL OF INFECTIOUS DISEASES

Cell-Based Measures of Viral Persistence Are Associated With Immune Activation and Programmed Cell Death Protein 1 (PD-1)–Expressing CD4+ T cells

(2012) Hiroyu Hatano et al.   JOURNAL OF INFECTIOUS DISEASES

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Reactivation of Latent HIV-1 by Inhibition of BRD4

(2012) Jian Zhu et al.   Cell Reports

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

(2011) Raymond Wong et al.   Retrovirology

Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

(2010) M. Tyagi et al.   JOURNAL OF VIROLOGY

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Histone deacetylase inhibitors and HIV latency

(2010) David M Margolis   Current Opinion in HIV and AIDS

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

(2009) Hung-Chih Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression

(2009) K. S. Keedy et al.   JOURNAL OF VIROLOGY

Isolation of a cellular factor that can reactivate latent HIV-1 without T cell activation

(2009) H.-C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recruitment of a SAP18-HDAC1 Complex into HIV-1 Virions and Its Requirement for Viral Replication

(2009) Masha Sorin et al.   PLoS Pathogens

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

(2008) S. M. Yoh et al.   GENES & DEVELOPMENT

Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation

(2008) L. Ajamian et al.   RNA

Relationship between T Cell Activation and CD4+T Cell Count in HIV‐Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

(2007) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES