Review
Cell Biology
Mohamad Mahjoor, Golnaz Mahmoudvand, Simin Farokhi, Alireza Shadab, Mojtaba Kashfi, Hamed Afkhami
Summary: The JAK/STAT signaling cascade plays a crucial role in regulating cell growth and differentiation, as well as immune responses and viral pathogenesis.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Jiali Wang, Jia Liu, Mingyang Wang, Fei Zhao, Meili Ge, Li Liu, Erlie Jiang, Sizhou Feng, Mingzhe Han, Xiaolei Pei, Yizhou Zheng
Summary: This study investigated the immunoregulatory mechanism of levamisole (LMS) in the treatment of aplastic anemia (AA) and confirmed its effectiveness through clinical retrospective study and animal models. The results showed that LMS can improve AA by inhibiting T-cell activation and regulating related molecules.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Qianqian Yin, Longyun Wang, Haiyang Yu, Daquan Chen, Wenwei Zhu, Changgang Sun
Summary: The JAK-STAT signaling pathway is closely related to cell proliferation, apoptosis, differentiation, and inflammatory response, essential for inhibiting inflammation, initiating innate immunity, and coordinating adaptive immune mechanisms. Various plant polyphenol compounds play a role in suppressing abnormal activation in the JAK-STAT pathway, showing significant effects in anti-inflammatory, antitumor, and cardiovascular disease control.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Fisheries
Hengwei Deng, Danrong Xian, Taixin Lian, Mingyu He, Jingjing Li, Xiaopeng Xu, Zhixun Guo, Jianguo He, Shaoping Weng
Summary: A Dicer2 gene named SpDicer2 from Scylla paramamosain was cloned and characterized. SpDicer2 plays an important role in defending against MCRV in mud crab by activating the JAK/STAT signaling pathways, influencing multiple immune pathways and the expression of immune effector genes.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Review
Immunology
Sherihan Salaheldin Abdelhamid Ibrahim, Kristiina M. Huttunen
Summary: Cell signaling is crucial for regulating basic cellular activities, with dysregulated activation and crosstalk between multiple pathways implicated in diseases like rheumatoid arthritis. Understanding the orchestrated modulation of these pathways is key to developing more effective therapeutic options.
INFLAMMOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Saeed Mohammadian Haftcheshmeh, Maliheh Abedi, Kazem Mashayekhi, Mohammad Javad Mousavi, Jamshid Gholizadeh Navashenaq, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni
Summary: This review discusses the modulatory effects of berberine (BBR) on various inflammatory signaling pathways in the immune system and explores its therapeutic efficacy and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Hyunjung Park, Sangjik Lee, Jaehun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: This review highlights the importance of the JAK/STAT pathway in hepatocellular carcinoma (HCC) and its association with factors such as chronic inflammation and cirrhosis. It also summarizes recent advancements in targeting the JAK/STAT pathway for HCC treatment, emphasizing the potential of this pathway as a promising avenue for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Qiuyu Pang, Lu You, Xiangmin Meng, Yumeng Li, Tian Deng, Deyong Li, Bingmei Zhu
Summary: The JAK/STAT signaling pathway plays a crucial role in cell growth, differentiation, immune response, and hematopoietic system development. It has been found to have regulatory functions in various cardiovascular diseases, such as myocardial ischemia-reperfusion injury, acute myocardial infarction, hypertension, myocarditis, heart failure, angiogenesis, and fibrosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Malgorzata Galecka, Janusz Szemraj, Kuan-Pin Su, Angelos Halaris, Michael Maes, Aleksandra Skiba, Piotr Galecki, Katarzyna Blizniewska-Kowalska
Summary: This study found that there is increased expression of JAK3 and decreased expression of STAT1 in depressed patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Gaetano La Rocca, Francesco Ferro, Chiara Baldini, Alessandro Libra, Domenico Sambataro, Michele Colaci, Lorenzo Malatino, Stefano Palmucci, Carlo Vancheri, Gianluca Sambataro
Summary: In recent years, the role of innate immunity, specifically interferon (IFN) and Interleukin 6, in idiopathic inflammatory myopathies (IIM) has gained increased attention. Both of these molecules transmit their signals through JAK/STAT pathway. This review focuses on evaluating the involvement of the JAK/STAT pathway in IIM, and discusses the potential therapeutic role of JAK inhibitors in diseases with strong IFN signature, such as dermatomyositis and antisynthetase syndrome.
FRONTIERS IN MEDICINE
(2023)
Article
Plant Sciences
Xinying Fu, Zhengji Sun, Qingyin Long, Wei Tan, Huang Ding, Xiaodan Liu, Lu Wu, Yang Wang, Wei Zhang
Summary: This study demonstrated that glycosides, the main active components of BYHWD, can inhibit atherosclerosis progression by alleviating atherosclerotic inflammation, with the inhibitory mechanism targeting the activation of the JAK/STAT signaling pathway.
Review
Neurosciences
Huaiyu Sun, Di Ma, Yu Cheng, Jiaai Li, Wuqiong Zhang, Ting Jiang, Zhaoran Li, Xuewei Li, Hongmei Meng
Summary: Epilepsy is characterized by spontaneous recurrent seizures in the brain. Inflammatory mediators and immune cells play a role in epileptic seizures, and the JAK-STAT signaling pathway shows potential as a target for epilepsy treatment.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Fisheries
Peiyu Yan, Cheng Lin, Meng He, Zhuofan Zhang, Qun Zhao, Erchao Li
Summary: This study investigated the regulatory mechanism of JAK/STAT signaling pathway on the immune system of Litopenaeus vannamei. Results indicated that the JAK/STAT pathway positively regulates cellular and humoral immune responses against LPS stimulation in shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Food Science & Technology
Hoon Kim, Jeong-Ju Lim, Hyun Young Shin, Hyung Joo Suh, Hyeon-Son Choi
Summary: The study demonstrated that the paraprobiotic LAB-P effectively inhibited lipid accumulation in preadipocytes by regulating early adipogenic factors and signaling pathways, suggesting its potential as a functional food material for controlling obesity and related diseases.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Multidisciplinary
Leishemba K. Thoidingjam, Cedric M. Blouin, Christine Gaillet, Aurelien Brion, Stephanie Solier, Supaporn Niyomchon, Ahmed El Marjou, Sara Mouasni, Fernando E. Sepulveda, Genevieve de Saint Basile, Christophe Lamaze, Raphael Rodriguez
Summary: Interferons (IFNs), important cytokines, play roles in triggering downstream biochemical events upon binding to cell surface receptors. Dysregulated IFN signaling has been linked to cancer progression and autoimmune diseases. Researchers have identified a small molecule that can block the activation of IFN signaling and further developing a more potent analogue that shows potential therapeutic effects in reducing bleeding in a model of hemorrhagic colitis. This first-in-class small molecule also inhibits other types of IFN-induced signaling. This research provides a foundation for the development of pan-IFN inhibitory drugs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Arig Ibrahim-Hashim, Kimberly Luddy, Dominique Abrahams, Pedro Enriquez-Navas, Sultan Damgaci, Jiqiang Yao, Tingan Chen, Marilyn M. Bui, Robert J. Gillies, Cliona O'Farrelly, Christina L. Richards, Joel S. Brown, Robert A. Gatenby
Summary: The progression of cancer is influenced by evolutionary dynamics in both the tumor population and its host. Host species can evolve defense strategies, both immunologic and non-immunologic, against tumors over generations. However, cancer cell plasticity allows for effective counter strategies against host defenses.
BRITISH JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
David A. Crosby, Louise E. Glover, Paul Downey, Eoghan E. Mooney, Fionnuala M. McAuliffe, Cliona O'Farrelly, Donal J. Brennan, Mary Wingfield
Summary: In this study, there were no differences in implantation rates, clinical pregnancy rates, or live birth rates between nulliparous women who underwent a accurately timed mid-luteal scratch biopsy prior to ART and those who did not undergo the procedure.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Obstetrics & Gynecology
David A. Crosby, Louise E. Glover, Paul Downey, Eoghan E. Mooney, Fionnuala M. McAuliffe, Cliona O'Farrelly, Donal J. Brennan, Mary Wingfield
Summary: This study aimed to predict pregnancy outcomes in assisted reproduction treatment by evaluating endometrial thickness, morphology, and uterine artery Doppler parameters. Results showed that ultrasound assessment of the endometrium did not differentiate between patients who would have a subsequent clinical pregnancy.
Review
Immunology
Ola Ahmed, Mark W. Robinson, Cliona O'Farrelly
Summary: The hepatic immune system plays a crucial role in maintaining homeostasis, but imbalance can lead to pathological conditions. Scientific evidence links dysregulated hepatic immune and inflammatory responses to various liver diseases, although the molecular mechanisms driving these associations are not well understood.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Niamh Allen, Una Ni Riain, Niall Conlon, Annamaria Ferenczi, Antonio Isidro Carrion Martin, Lisa Domegan, Cathal Walsh, Lorraine Doherty, Cliona O'Farrelly, Eibhlin Higgins, Colm Kerr, Jonathan McGrath, Colm Bergin, Catherine Fleming, Margaret Fitzgerald, Cillian de Gascun, Joan Gallagher, Derval Igoe, Mary Keogan, Noirin Noonan, Una Ni Rian, Breda Smyth, Catherine Fleming
Summary: Hospital healthcare workers in Ireland have a high seroprevalence of SARS-CoV-2 antibodies, with 39% of infections being previously undiagnosed. High-risk groups include healthcare assistants, nurses, those with daily exposure to COVID-19 patients, individuals aged 18-29, those living with other healthcare workers, individuals of Asian background, and males.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Immunology
Liam Townsend, Adam H. Dyer, Aifric Naughton, Rachel Kiersey, Dean Holden, Mary Gardiner, Joanne Dowds, Kate O'Brien, Ciaran Bannan, Parthiban Nadarajan, Jean Dunne, Ignacio Martin-Loeches, Padraic G. Fallon, Colm Bergin, Cliona O'Farrelly, Cliona Ni Cheallaigh, Nollaig M. Bourke, Niall Conlon
Summary: The study found persistent changes in immune cell parameters in convalescent COVID-19 patients over three months after initial infection, with more marked abnormalities in older patients. However, these changes were not associated with subjective health status, fatigue, and exercise tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ioannis Kienes, Sarah Bauer, Clarissa Gottschild, Nora Mirza, Jens Pfannstiel, Martina Schroeder, Thomas A. Kufer
Summary: The study reveals that NLRP11 plays a role in regulating type I IFN induction during viral infection and controls NLRP3 inflammasome activation by binding to DDX3X. NLRP11 abolishes IKK epsilon-mediated phosphorylation of DDX3X, leading to reduced type I IFN induction upon viral infection. By interacting with DDX3X through the LRR domain, NLRP11 suppresses NLRP3-mediated inflammasome activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Ola Ahmed, Min Xu, Fangyu Zhou, Alexander N. Wein, Gundumi A. Upadhya, Li Ye, Brian W. Wong, Yiing Lin, Cliona O'Farrelly, William C. Chapman
Summary: Antioxidant defense mechanisms, particularly the NRF2 axis, play a crucial role in oxidative stress responses and ischemic injury. High NRF2 expression in donor livers is associated with improved liver function, suggesting that targeting this axis may be a rational supplemental treatment strategy for rescuing marginal donor livers.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Dermatology
Lisa M. Arkin, John J. Moon, Jennifer M. Tran, Samira Asgan, Cliona O'Farrelly, Jean-Laurent Casanova, Edward W. Cowen, Jacqueline W. Mays, Anne Marie Singh, Beth A. Drolet
Summary: Despite the large number of patients with pandemic-associated pernio, establishing a causal link to SARS-CoV-2 remains a challenge. Pathophysiological studies suggest that some children with pernio may have abnormalities in IFN-1 immunity, while excessive immune responses to SARS-CoV-2 are seen in the skin of pernio patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Irina Kareva, Kimberly A. Luddy, Cliona O'Farrelly, Robert A. Gatenby, Joel S. Brown
Summary: Tumor-immune interactions are often compared to predator-prey relationships, where immune cells act as predators and target immunogenic tumor cells as prey. However, the dynamics in tumor microenvironment differ from traditional predator-prey models, as immune cells and tumor cells actually compete for resources rather than supporting each other. Also, unlike standard predator-prey models, oncology shows an increase in tumor volume and a decrease in infiltrating immune cell populations, rather than cycling population sizes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jyotsna Pardeshi, Niamh McCormack, Lili Gu, Cathal S. Ryan, Martina Schroder
Summary: This study reveals a novel physical interaction between DDX3X and ERα, which positively regulates ERα activation. Knockdown of DDX3X reduces ERα phosphorylation, expression of target genes, and cell proliferation, while overexpression of DDX3X enhances ERα phosphorylation and activity. These findings suggest an important role of DDX3X in breast cancer development and resistance to endocrine therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Immunology
Evangelos Andreakos, Laurent Abel, Donald C. Vinh, Elzbieta Kaja, Beth A. Drolet, Qian Zhang, Cliona O'Farrelly, Giuseppe Novelli, Carlos Rodriguez-Gallego, Filomeen Haerynck, Carolina Prando, Aurora Pujol, Helen C. Su, Jean-Laurent Casanova, Andras N. Spaan, Paul Bastard, Catherine M. Biggs, Benedetta Bigio, Bertrand Boisson, Alexandre Bolze, Anastasiia Bondarenko, Petter Brodin, Samya Chakravorty, John Christodoulou, Aurelie Cobat, Antonio Condino-Neto, Stefan N. Constantinescu, Hagit Baris Feldman, Jacques Fellay, Rabih Halwani, Emmanuelle Jouanguy, Yu-Lung Lau, Isabelle Meyts, Trine H. Mogensen, Satoshi Okada, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarstrom, Anna M. Planas, Anne Puel, Lluis Quintana-Murci, Laurent Renia, Igor Resnick, Anna Sediva, Anna Shcherbina, Ondrej Slaby, Ivan Tancevski, Stuart E. Turvey, K. M. Furkan Uddin, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Shen-Ying Zhang
Summary: SARS-CoV-2 infections can vary greatly between individuals, with some being asymptomatic while others experience life-threatening disease. While 20% of critical COVID-19 cases are due to inborn errors or autoantibodies, the genetic and immunological factors for resistance to infection itself remain unknown. Studies have shown that autosomal recessive deficiencies in certain genes or enzymes can confer resistance to diseases, suggesting a potential strategy for identifying individuals naturally resistant to SARS-CoV-2 infection.
Review
Cell Biology
Cathal S. Ryan, Martina Schroeder
Summary: The human DEAD-box protein DDX3X plays a crucial role in RNA metabolism and has been associated with various diseases, including cancer and neurodevelopmental conditions. It also plays a significant role in viral infections. DDX3X is involved in translation initiation and stress response, and understanding its regulatory mechanisms is important for developing therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Cian Reid, Charlotte Beynon, Emer Kennedy, Cliona O'Farrelly, Kieran G. Meade
Summary: Research findings show that longitudinal profiling of innate immune responses in cattle using the IChek assay can capture biological variation between individuals, detecting different responses to cytokines and chemokines. By utilizing a standardized system, the potential for artefactual results is minimized, allowing for repeatable temporal comparative analysis in cattle.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Liam Townsend, Joanne Dowds, Kate O'Brien, Grainne Sheill, Adam H. Dyer, Brendan O'Kelly, John P. Hynes, Aoife Mooney, Jean Dunne, Cliona Ni Cheallaigh, Cliona O'Farrelly, Nollaig M. Bourke, Niall Conlon, Ignacio Martin-Loeches, Calm Bergin, Parthiban Nadarajan, Ciaran Bannan
Summary: This study reveals that some patients still experience respiratory diseases and subjective symptoms after COVID-19 infection, with ongoing health issues and fatigue often accompanied by a higher perception of exertion. Initial disease severity does not have a strong correlation with persistent respiratory diseases.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)