The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation

A generic approach to study the kinetics of liquid–liquid phase separation under near-native conditions

(2021) Joris Van Lindt et al.   Communications Biology

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biomolecular Condensates and Their Links to Cancer Progression

(2021) Danfeng Cai et al.   TRENDS IN BIOCHEMICAL SCIENCES

Liquid Biomolecular Condensates and Viral Lifecycles: Review and Perspectives

(2021) Temitope Etibor et al.   Viruses-Basel

Valency and Binding Affinity Variations Can Regulate the Multilayered Organization of Protein Condensates with Many Components

(2021) Ignacio Sanchez-Burgos et al.   Biomolecules

The role of liquid–liquid phase separation in regulating enzyme activity

(2021) Brian G. O'Flynn et al.   CURRENT OPINION IN CELL BIOLOGY

LncRNAs: Architectural Scaffolds or More Potential Roles in Phase Separation

(2021) Jie Luo et al.   Frontiers in Genetics

It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation

(2021) Hannah J. Wiedner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multiscale Approach for Computing Gated Ligand Binding from Molecular Dynamics and Brownian Dynamics Simulations

(2021) S. Kashif Sadiq et al.   Journal of Chemical Theory and Computation

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

A Guide to Regulation of the Formation of Biomolecular Condensates

(2020) Anna Bratek‐Skicki et al.   FEBS Journal

Biomolecular Phase Separation: From Molecular Driving Forces to Macroscopic Properties

(2020) Gregory L. Dignon et al.   Annual Review of Physical Chemistry

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components

(2020) Jorge R. Espinosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pan-retroviral Nucleocapsid-Mediated Phase Separation Regulates Genomic RNA Positioning and Trafficking

(2020) Anne Monette et al.   Cell Reports

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Restricting the sizes of condensates

(2020) Furqan Dar et al.   eLife

Fine-Tuning of Sequence Specificity by Near Attack Conformations in Enzyme-Catalyzed Peptide Hydrolysis

(2020) S. Kashif Sadiq   Catalysts

Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

(2020) Hui Chen et al.   CELL RESEARCH

Liquid–Liquid Phase Separation in Crowded Environments

(2020) Alain A. M. André et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enzymatic Reactions inside Biological Condensates

(2020) Yi Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA-binding and prion domains: the Yin and Yang of phase separation

(2020) Nieves Lorenzo Gotor et al.   NUCLEIC ACIDS RESEARCH

RNA as the stone guest of protein aggregation

(2020) Alexandra Louka et al.   NUCLEIC ACIDS RESEARCH

Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States

(2020) Assia Mouhand et al.   Viruses-Basel

Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates

(2020) Anne Monette et al.   Viruses-Basel

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

(2020) Jennifer L Elliott et al.   eLife

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

(2020) Theodora Myrto Perdikari et al.   EMBO JOURNAL

Liquid–Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus–Host Interactions

(2020) Stefania Brocca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

(2020) Christiane Iserman et al.   MOLECULAR CELL

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

(2020) Adriana Savastano et al.   Nature Communications

Biomolecular condensates as arbiters of biochemical reactions inside the nucleus

(2020) Guillaume Laflamme et al.   Communications Biology

Protein Phase Separation as a Stress Survival Strategy

(2019) Titus M. Franzmann et al.   Cold Spring Harbor Perspectives in Biology

Structural explorations of NCp7-nucleic acid complexes give keys to decipher the binding process

(2019) Romain Retureau et al.   JOURNAL OF MOLECULAR BIOLOGY

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Weak Chemical Interactions That Drive Protein Evolution: Crowding, Sticking, and Quinary Structure in Folding and Function

(2019) Drishti Guin et al.   CHEMICAL REVIEWS

In-Cell Protein–Protein Contacts: Transient Interactions in the Crowd

(2019) Meredith M. Rickard et al.   Journal of Physical Chemistry Letters

Three archetypical classes of macromolecular regulators of protein liquid–liquid phase separation

(2019) Archishman Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications

(2019) Zhe Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Reconstitution of HIV-1 Assembly and Maturation

(2019) Iga Kucharska et al.   JOURNAL OF VIROLOGY

Physical Principles and Extant Biology Reveal Roles for RNA-Containing Membraneless Compartments in Origins of Life Chemistry

(2018) Raghav R. Poudyal et al.   BIOCHEMISTRY

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

(2018) Mario Hofweber et al.   CELL

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

(2018) Seema Qamar et al.   CELL

Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis

(2018) Assia Mouhand et al.   NUCLEIC ACIDS RESEARCH

Organization and Function of Non-dynamic Biomolecular Condensates

(2018) Jeffrey B. Woodruff et al.   TRENDS IN BIOCHEMICAL SCIENCES

Why Do Disordered and Structured Proteins Behave Differently in Phase Separation?

(2018) Huan-Xiang Zhou et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

(2016) Jacques J. Kessl et al.   CELL

Mechanistic insights into mammalian stress granule dynamics

(2016) Marc D. Panas et al.   JOURNAL OF CELL BIOLOGY

The Race against Protease Activation Defines the Role of ESCRTs in HIV Budding

(2016) Mourad Bendjennat et al.   PLoS Pathogens

Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress

(2015) Edward W.J. Wallace et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro

(2015) Marc Potempa et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA and Nucleocapsid Are Dispensable for Mature HIV-1 Capsid Assembly

(2015) Simone Mattei et al.   JOURNAL OF VIROLOGY

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation

(2015) Juan Fontana et al.   JOURNAL OF VIROLOGY

It’s Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles

(2015) Lin Guo et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy

(2015) Lalit Deshmukh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinary structure modulates protein stability in cells

(2015) William B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retroviral proteases and their roles in virion maturation

(2015) Jan Konvalinka et al.   VIROLOGY

Super-Resolution Imaging of ESCRT-Proteins at HIV-1 Assembly Sites

(2015) Jens Prescher et al.   PLoS Pathogens

Computing the Role of Near Attack Conformations in an Enzyme-Catalyzed Nucleophilic Bimolecular Reaction

(2014) S. Kashif Sadiq et al.   Journal of Chemical Theory and Computation

Challenges and dreams: physics of weak interactions essential to life

(2014) Peter Chien et al.   MOLECULAR BIOLOGY OF THE CELL

Emergent mechanics of biological structures

(2014) Sophie Dumont et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity

(2014) W. Wang et al.   NUCLEIC ACIDS RESEARCH

HIV-1 nucleocapsid and ESCRT-component Tsg101 interplay prevents HIV from turning into a DNA-containing virus

(2014) Célia Chamontin et al.   NUCLEIC ACIDS RESEARCH

mRNP granules

(2014) J Ross Buchan   RNA Biology

Selection of fully processed HIV-1 nucleocapsid protein is required for optimal nucleic acid chaperone activity in reverse transcription

(2014) Tiyun Wu et al.   VIRUS RESEARCH

Specific recognition of the HIV-1 genomic RNA by the Gag precursor

(2014) Ekram W. Abd El-Wahab et al.   Nature Communications

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

Rapid Conformational Fluctuations of Disordered HIV-1 Fusion Peptide in Solution

(2013) Tom Venken et al.   Journal of Chemical Theory and Computation

Differential contribution of basic residues to HIV-1 nucleocapsid protein’s nucleic acid chaperone function and retroviral replication

(2013) Hao Wu et al.   NUCLEIC ACIDS RESEARCH

HIV-1 Assembly, Budding, and Maturation

(2013) W. I. Sundquist et al.   Cold Spring Harbor Perspectives in Medicine

Gag-Pol Processing during HIV-1 Virion Maturation: A Systems Biology Approach

(2013) Balázs Könnyű et al.   PLoS Computational Biology

The Choreography of HIV-1 Proteolytic Processing and Virion Assembly

(2012) Sook-Kyung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the SP2 Domain and Its Proteolytic Cleavage in HIV-1 Structural Maturation and Infectivity

(2012) A. de Marco et al.   JOURNAL OF VIROLOGY

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Aromatic residue mutations reveal direct correlation between HIV-1 nucleocapsid protein's nucleic acid chaperone activity and retroviral replication

(2012) Hao Wu et al.   VIRUS RESEARCH

Visualizing HIV-1 Assembly

(2011) Nolwenn Jouvenet et al.   JOURNAL OF MOLECULAR BIOLOGY

Reaction Kinetics of Catalyzed Competitive Heteropolymer Cleavage

(2011) S. Kashif Sadiq et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Single-molecule stretching studies of RNA chaperones

(2011) Hao Wu et al.   RNA Biology

Features, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein function

(2011) Gilles Mirambeau et al.   RNA Biology

Human Immunodeficiency Virus Type 1 Nucleocapsid p1 Confers ESCRT Pathway Dependence

(2010) E. Popova et al.   JOURNAL OF VIROLOGY

Basic Residues in the Nucleocapsid Domain of Gag Are Critical for Late Events of HIV-1 Budding

(2010) V. Dussupt et al.   JOURNAL OF VIROLOGY

C-terminal Domain Modulates the Nucleic Acid Chaperone Activity of Human T-cell Leukemia Virus Type 1 Nucleocapsid Protein via an Electrostatic Mechanism

(2009) Dominic F. Qualley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ACEMD: Accelerating Biomolecular Dynamics in the Microsecond Time Scale

(2009) M. J. Harvey et al.   Journal of Chemical Theory and Computation

Effect of Mg2+ and Na+ on the Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein: Implications for Reverse Transcription

(2009) My-Nuong Vo et al.   JOURNAL OF MOLECULAR BIOLOGY

Dimer Disruption and Monomer Sequestration by Alkyl Tripeptides Are Successful Strategies for Inhibiting Wild-Type and Multidrug-Resistant Mutated HIV-1 Proteases†

(2008) Ludovic Bannwarth et al.   BIOCHEMISTRY

Retroviral Nucleocapsid Proteins Display Nonequivalent Levels of Nucleic Acid Chaperone Activity

(2008) K. M. Stewart-Maynard et al.   JOURNAL OF VIROLOGY

Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: Effects on virion morphogenesis and RNA maturation

(2008) Michael D. Moore et al.   VIROLOGY