Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistance
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Title
Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistance
Authors
Keywords
antimicrobial resistance, efflux pumps, efflux pump inhibitor, Mycobacterium tuberculosis
Journal
TRENDS IN MICROBIOLOGY
Volume 30, Issue 1, Pages 57-68
Publisher
Elsevier BV
Online
2021-05-26
DOI
10.1016/j.tim.2021.05.001
References
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Note: Only part of the references are listed.- Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in Mycobacterium tuberculosis
- (2021) Kentaro Yamamoto et al. mSphere
- Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species
- (2020) Julia Solnier et al. MOLECULES
- Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps
- (2020) Sanath Kumar et al. Microorganisms
- Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs
- (2020) Liliana Rodrigues et al. Expert Review of Anti-Infective Therapy
- A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds
- (2020) S. Rempel et al. NATURE
- Synthesis and biological evaluation of 12 novel (-)-camphene-based 1,3,4-thiadiazoles against Mycobacterium tuberculosis
- (2020) Giovana F Costacurta et al. Future Microbiology
- Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
- (2020) Andrei Papkou et al. Nature Communications
- Antimicrobial and Efflux Pump Inhibitory Activity of Carvotacetones from Sphaeranthus africanus Against Mycobacteria
- (2020) Huyen Thi Tran et al. Antibiotics-Basel
- In vitro Study of Bedaquiline Resistance in Mycobacterium tuberculosis Multi-Drug Resistant Clinical Isolates
- (2020) Giulia Degiacomi et al. Frontiers in Microbiology
- Stepwise acquisition of rv0678 and atpE mutations conferring bedaquiline resistance: an in vitro study
- (2019) Nabila Ismail et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Mycobacterium tuberculosis Rv0191 is an efflux pump of major facilitator superfamily transporter regulated by Rv1353c
- (2019) Xue Li et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Synthesis and mycobacterial evaluation of 5‐substituted‐6‐acetyl‐2‐amino‐7‐methyl‐5,8‐dihydropyrido‐[2,3‐ d ]pyrimidin‐4(3 H )‐one derivatives
- (2019) Neha Agre et al. ARCHIV DER PHARMAZIE
- Antibiotic Resistance Breakers: Current Approaches and Future Directions
- (2019) Mark Laws et al. FEMS MICROBIOLOGY REVIEWS
- Exploration of 5‐(5‐nitrothiophen‐2‐yl)‐4,5‐dihydro‐1H‐pyrazoles as selective, multitargeted antimycobacterial agents
- (2019) Neha Agre et al. Chemical Biology & Drug Design
- Hydrazone, benzohydrazones and isoniazid-acylhydrazones as potential antituberculosis agents
- (2019) Eloísa G Sampiron et al. Future Microbiology
- Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine
- (2019) Fabian Lentz et al. MOLECULES
- Resistance To First-Line Antituberculosis Drugs And Prevalence Of pncA Mutations In Clinical Isolates Of Mycobacterium tuberculosis From Zunyi, Guizhou Province Of China
- (2019) Zhimin Cao et al. Infection and Drug Resistance
- Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis
- (2018) Chao Chen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Reversed isoniazids: Design, synthesis and evaluation against Mycobacterium tuberculosis
- (2018) Malkeet Kumar et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Carvacrol activity & morphological changes in Mycobacterium tuberculosis
- (2018) Sandra S Nakamura de Vasconcelos et al. Future Microbiology
- Resistance to first- and second-line antituberculosis drugs in Southern Taiwan: Implications for empirical treatment
- (2018) Cheng-Yu Kuo et al. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
- Discovery of Novel Enhancers of Isoniazid Toxicity in Mycobacterium tuberculosis
- (2018) Fabian Lentz et al. MOLECULES
- Multidrug efflux pumps: structure, function and regulation
- (2018) Dijun Du et al. NATURE REVIEWS MICROBIOLOGY
- Structural basis for the alternating access mechanism of the cation diffusion facilitator YiiP
- (2018) Maria Luisa Lopez-Redondo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
- (2018) Cynthia A. Danquah et al. Scientific Reports
- Efflux pump inhibition by 11H-pyrido[2,1-b]quinazolin-11-one analogues in mycobacteria
- (2018) Tejosmita Sen et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design and synthesis of 5-(5-nitrothiophen-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazole derivatives with improved solubility and potential antituberculosis activity
- (2018) Mihir Khambete et al. Chemical Biology & Drug Design
- Mycobacterium tuberculosis Rv1473 is a novel macrolides ABC Efflux Pump regulated by WhiB7
- (2018) Wei Duan et al. Future Microbiology
- Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence
- (2018) Diana Machado et al. Frontiers in Microbiology
- Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis
- (2017) Nicolò Scalacci et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Siderophore transport by MmpL5-MmpS5 protein complex in Mycobacterium tuberculosis
- (2017) Padmani Sandhu et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Mycobacterium tuberculosis Major Facilitator Superfamily Transporters
- (2017) Ping Li et al. JOURNAL OF MEMBRANE BIOLOGY
- MmpS5/MmpL5 as an efflux pump in Mycobacterium species
- (2017) Julien Briffotaux et al. TUBERCULOSIS
- Discovery of novel N- phenyl 1,4-dihydropyridines with a dual mode of antimycobacterial activity
- (2016) Fabian Lentz et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Development of efflux pump inhibitors in antituberculosis therapy
- (2016) Lele Song et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N′-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria
- (2016) Sanjib Bhakta et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phase II metabolic pathways of spectinamide antitubercular agents: a comparative study of the reactivity of 4-substituted pyridines to glutathione conjugation
- (2016) Dora B. Madhura et al. MedChemComm
- First-Line Anti-Tubercular Drug Resistance of Mycobacterium tuberculosis in IRAN: A Systematic Review
- (2016) Babak Pourakbari et al. Frontiers in Microbiology
- Structure–Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions
- (2016) Jiuyu Liu et al. ACS Infectious Diseases
- Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis
- (2016) Malkeet Kumar et al. ACS Infectious Diseases
- Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis
- (2016) Diana Machado et al. PLoS One
- A Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to Antibiotics
- (2016) Yonatan Shuster et al. PLoS One
- Structural Biology of the Major Facilitator Superfamily Transporters
- (2015) Nieng Yan Annual Review of Biophysics
- New Verapamil Analogs Inhibit Intracellular Mycobacteria without Affecting the Functions of Mycobacterium-Specific T Cells
- (2015) Getahun Abate et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- SILA-421 activity in vitro against rifampicin-susceptible and rifampicin-resistant Mycobacterium tuberculosis, and in vivo in a murine tuberculosis model
- (2015) Gerjo J. de Knegt et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates
- (2015) Guilian Li et al. JOURNAL OF ANTIBIOTICS
- Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy
- (2015) Caroline M. Pule et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics
- (2015) David F. Bruhn et al. Scientific Reports
- Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis
- (2014) R. C. Hartkoorn et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Understanding pharmacokinetics to improve tuberculosis treatment outcome
- (2014) Jonathan Reynolds et al. Expert Opinion on Drug Metabolism & Toxicology
- Mechanisms of fluoroquinolone monoresistance inMycobacterium tuberculosis
- (2014) Jie Lu et al. FEMS MICROBIOLOGY LETTERS
- FDA Approval of Bedaquiline — The Benefit–Risk Balance for Drug-Resistant Tuberculosis
- (2014) Edward Cox et al. NEW ENGLAND JOURNAL OF MEDICINE
- Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline
- (2014) Koen Andries et al. PLoS One
- Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis
- (2013) Shashank Gupta et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Bedaquiline: A new drug approved for treatment of multidrug-resistant tuberculosis
- (2013) Shashank Deoghare INDIAN JOURNAL OF PHARMACOLOGY
- Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis
- (2013) Sami O. Simons et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Characterization of the MSMEG_2631 Gene (mmp) Encoding a Multidrug and Toxic Compound Extrusion (MATE) Family Protein in Mycobacterium smegmatis and Exploration of Its Polyspecific Nature Using Biolog Phenotype MicroArray
- (2013) M. N. Mishra et al. JOURNAL OF BACTERIOLOGY
- Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis
- (2013) Ryan M. Wells et al. PLoS Pathogens
- Efflux Pumps of Mycobacterium tuberculosis Play a Significant Role in Antituberculosis Activity of Potential Drug Candidates
- (2012) Meenakshi Balganesh et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Role of the Mmr Efflux Pump in Drug Resistance in Mycobacterium tuberculosis
- (2012) L. Rodrigues et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis
- (2012) Jani Reddy Bolla et al. NUCLEIC ACIDS RESEARCH
- Enhanced bacterial efflux system is the first step to the development of metronidazole resistance in Helicobacter pylori
- (2010) Hitoshi Tsugawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Efflux‐Pump–Derived Multiple Drug Resistance to Ethambutol Monotherapy inMycobacterium tuberculosisand the Pharmacokinetics and Pharmacodynamics of Ethambutol
- (2010) Shashikant Srivastava et al. JOURNAL OF INFECTIOUS DISEASES
- SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis (XDR-TB)
- (2009) Marta Martins et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Microarray Analysis of Efflux Pump Genes in Multidrug-Resistant Mycobacterium tuberculosis During Stress Induced by Common Anti-Tuberculous Drugs
- (2009) Anuj Kumar Gupta et al. Microbial Drug Resistance
- Identification of a Novel Multidrug Efflux Pump of Mycobacterium tuberculosis
- (2008) O. Danilchanka et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis
- (2008) L. Rodrigues et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Tuberculosis Diagnosis and Multidrug Resistance Testing by Direct Sputum Culture in Selective Broth without Decontamination or Centrifugation
- (2008) L. Grandjean et al. JOURNAL OF CLINICAL MICROBIOLOGY
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