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Title
MANF: an emerging therapeutic target for metabolic diseases
Authors
Keywords
MANF, glucose homeostasis, lipid metabolism, energy balance, inflammation, metabolic diseases
Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2022-02-06
DOI
10.1016/j.tem.2022.01.001
References
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Related references
Note: Only part of the references are listed.- Loss of MANF causes childhood onset syndromic diabetes due to increased endoplasmic reticulum stress
- (2021) Hossam Montaser et al. DIABETES
- The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
- (2021) Ave Eesmaa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The relationship of mesencephalic astrocyte-derived neurotrophic factor with hyperlipidemia in patients with or without type 2 diabetes mellitus
- (2021) Jili Fu et al. Hormones-International Journal of Endocrinology and Metabolism
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- (2021) Changhui Wang et al. INFLAMMATION
- Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway
- (2021) Tong Wu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency
- (2021) Ziyu Ren et al. Frontiers in Endocrinology
- Decreased Circulating MANF in Women with PCOS is Elevated by Metformin Therapy and is Inversely Correlated with Insulin Resistance and Hyperandrogenism
- (2020) Jie Wei et al. HORMONE AND METABOLIC RESEARCH
- MANF Promotes Diabetic Corneal Epithelial Wound Healing and Nerve Regeneration by Attenuating Hyperglycemia-Induced Endoplasmic Reticulum Stress
- (2020) Xiaochuan Wang et al. DIABETES
- Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart
- (2020) Adrian Arrieta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement
- (2020) Mohammed Eslam et al. JOURNAL OF HEPATOLOGY
- Urinary ERdj3 and mesencephalic astrocyte-derived neutrophic factor identify endoplasmic reticulum stress in glomerular disease
- (2020) Nihad Tousson-Abouelazm et al. LABORATORY INVESTIGATION
- Mesencephalic astrocyte-derived neurotrophic factor ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism
- (2020) Miao He et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover
- (2020) Jili Fu et al. LIFE SCIENCES
- Role of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Alcohol-Induced Liver Injury
- (2020) Goma Chhetri et al. Oxidative Medicine and Cellular Longevity
- Neuroplastin Modulates Anti-inflammatory Effects of MANF
- (2020) Takuya Yagi et al. iScience
- MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
- (2019) Yahui Yan et al. Nature Communications
- Endoplasmic Reticulum Stress, the Hypothalamus, and Energy Balance
- (2019) Isin Cakir et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome
- (2019) Sun-Ji Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MANF inhibits liver cancer via SUMO ylation‐related suppression of NF ‐κB/Snail signaling pathway and epithelial‐mesenchymal transition
- (2019) Jun Liu et al. HEPATOLOGY
- MANF regulates splenic macrophage differentiation in mice
- (2019) Chao Hou et al. IMMUNOLOGY LETTERS
- Circulating Mesencephalic Astrocyte-derived Neurotrophic Factor Negatively Correlates with Atrial Apoptosis in Human Chronic Atrial Fibrillation
- (2019) Changhui Wang et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice
- (2019) Emilia Galli et al. Scientific Reports
- Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function
- (2019) Tatiana Danilova et al. Frontiers in Endocrinology
- MANF protects human pancreatic beta cells against stress-induced cell death
- (2018) Elina Hakonen et al. DIABETOLOGIA
- XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B
- (2018) Dong Wang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection
- (2018) Meirong Bai et al. Nature Communications
- Poststroke delivery of MANF promotes functional recovery in rats
- (2018) Kert Mätlik et al. Science Advances
- MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice
- (2018) Tatiana Danilova et al. DIABETES
- Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway
- (2017) Jingxing Zhang et al. EXPERIMENTAL GERONTOLOGY
- Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)
- (2017) Daniel A. Cunha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inflammation, metaflammation and immunometabolic disorders
- (2017) Gökhan S. Hotamisligil NATURE
- MANF regulates hypothalamic control of food intake and body weight
- (2017) Su Yang et al. Nature Communications
- Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases
- (2016) Y. Kim et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Immune modulation by MANF promotes tissue repair and regenerative success in the retina
- (2016) J. Neves et al. SCIENCE
- Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes
- (2016) Emilia Galli et al. Scientific Reports
- Hypothalamic ER stress: A bridge between leptin resistance and obesity
- (2015) Sara Ramírez et al. FEBS LETTERS
- High diagnostic yield of clinical exome sequencing in Middle Eastern patients with Mendelian disorders
- (2015) Tarunashree Yavarna et al. HUMAN GENETICS
- Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway
- (2015) Lijian Chen et al. Scientific Reports
- Age-Dependent Decrease in Chaperone Activity Impairs MANF Expression, Leading to Purkinje Cell Degeneration in Inducible SCA17 Mice
- (2014) Su Yang et al. NEURON
- MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells
- (2014) Maria Lindahl et al. Cell Reports
- Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases
- (2013) Claire L. Hartley et al. HUMAN MOLECULAR GENETICS
- Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Secretion and Cell Surface Binding Are Modulated by KDEL Receptors
- (2012) Mark J. Henderson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion
- (2012) Christopher C. Glembotski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation
- (2012) Yujun Shen et al. Journal of Neuroinflammation
- 1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor
- (2010) Maarit Hellman et al. Biomolecular NMR Assignments
- Solution structure and dynamics of mouse ARMET
- (2010) Jun Hoseki et al. FEBS LETTERS
- Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons
- (2010) Maarit Hellman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure
- (2010) Christopher C. Glembotski JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Induction Profile of MANF/ARMET by Cerebral Ischemia and its Implication for Neuron Protection
- (2009) Yong-Qiang Yu et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional
- (2009) Vimal Parkash et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Mesencephalic Astrocyte-Derived Neurotrophic Factor Is an Ischemia-Inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart
- (2008) Archana Tadimalla et al. CIRCULATION RESEARCH
- Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death
- (2008) A APOSTOLOU et al. EXPERIMENTAL CELL RESEARCH
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