MANF protects human pancreatic beta cells against stress-induced cell death

Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection

(2018) Meirong Bai et al.   Nature Communications

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

(2018) Violeta Georgieva Tsonkova et al.   Molecular Metabolism

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

(2017) Daniel A. Cunha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication

(2016) Sangeeta Dhawan et al.   DIABETES

Single-cell transcriptome analysis of endometrial tissue

(2016) K. Krjutškov et al.   HUMAN REPRODUCTION

Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases

(2016) Y. Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

(2016) James Dooley et al.   NATURE GENETICS

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

(2016) Flora Brozzi et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

(2016) Emilia Galli et al.   Scientific Reports

A human beta cell line with drug inducible excision of immortalizing transgenes

(2015) Marion Benazra et al.   Molecular Metabolism

Functional Characterization of Zebrafish (Danio rerio) Bcl10

(2015) Pellegrino Mazzone et al.   PLoS One

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway

(2015) Lijian Chen et al.   Scientific Reports

MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells

(2014) Maria Lindahl et al.   Cell Reports

RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells

(2014) Vikash Chandra et al.   Cell Reports

SAMstrt: statistical test for differential expression in single-cell transcriptome with spike-in normalization

(2013) Shintaro Katayama et al.   BIOINFORMATICS

Combined modulation of polycomb and trithorax genes rejuvenates β cell replication

(2013) Josie X. Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Secretion and Cell Surface Binding Are Modulated by KDEL Receptors

(2012) Mark J. Henderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

Endoplasmic reticulum stress, obesity and diabetes

(2011) Miriam Cnop et al.   TRENDS IN MOLECULAR MEDICINE

Collecting high-quality pancreatic tissue for experimental study from organ donors with signs of β-cell autoimmunity

(2010) Sisko Tauriainen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons

(2010) Maarit Hellman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-17 Immunity in Human Type 1 Diabetes

(2010) J. Honkanen et al.   JOURNAL OF IMMUNOLOGY

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Beta cell apoptosis in diabetes

(2009) Helen E. Thomas et al.   APOPTOSIS

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Neurorestorative in Rat Model of Parkinson's Disease

(2009) M. H. Voutilainen et al.   JOURNAL OF NEUROSCIENCE

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is an Ischemia-Inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart

(2008) Archana Tadimalla et al.   CIRCULATION RESEARCH

Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death

(2008) A APOSTOLOU et al.   EXPERIMENTAL CELL RESEARCH