Sorafenib is an antagonist of the aryl hydrocarbon receptor

The aryl hydrocarbon receptor ligand ITE inhibits cell proliferation and migration and enhances sensitivity to drug‐resistance in hepatocellular carcinoma

(2020) Xiaoqian Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

AhR regulates the expression of human cytochrome P450 1A1 ( CYP 1A1 ) by recruiting Sp1

(2019) Wenchu Ye et al.   FEBS Journal

ITE, an endogenous aryl hydrocarbon receptor ligand, suppresses endometrial cancer cell proliferation and migration

(2019) Yiding Bian et al.   TOXICOLOGY

Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

(2019) Pallab Shaw et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Locoregional treatments for hepatocellular carcinoma: Current evidence and future directions

(2019) Riccardo Inchingolo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

(2019) Dmitry Kondrikov et al.   EXPERIMENTAL GERONTOLOGY

An endogenous aryl hydrocarbon receptor (AhR) ligand, ITE induces regulatory T cells (Tregs) and ameliorates experimental colitis

(2018) Jessicca D Abron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pregnane X receptor mediates sorafenib resistance in advanced hepatocellular carcinoma

(2018) Fan Feng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Shared epitope–aryl hydrocarbon receptor crosstalk underlies the mechanism of gene–environment interaction in autoimmune arthritis

(2018) Jiaqi Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma

(2018) Anna Bianchi-Smiraglia et al.   JOURNAL OF CLINICAL INVESTIGATION

Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine-specific homeobox expression

(2017) Shih-Hsien Hsu et al.   MOLECULAR CARCINOGENESIS

ITE Suppresses Angiogenic Responses in Human Artery and Vein Endothelial Cells: Differential Roles of AhR

(2017) Yan Li et al.   REPRODUCTIVE TOXICOLOGY

Increasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals

(2017) Junjie Xu et al.   Cell Death & Disease

Activation of aryl hydrocarbon receptor reduces carbendazim-induced cell death

(2016) Kuo-Liang Wei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Modulation of Autophagy by Sorafenib: Effects on Treatment Response

(2016) Nestor Prieto-Domínguez et al.   Frontiers in Pharmacology

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Aryl hydrocarbon receptor agonists upregulate VEGF secretion from bronchial epithelial cells

(2015) Ming-Ju Tsai et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cytochrome P450 1 family and cancers

(2015) Ryeo-Eun Go et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Sorafenib-based combination as a first line treatment for advanced hepatocellular carcinoma: A systematic review of the literature

(2014) Omar Abdel-Rahman et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Role of the modulation of CYP1A1 expression and activity in chemoprevention

(2014) S. Badal et al.   JOURNAL OF APPLIED TOXICOLOGY

Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes

(2013) Tejas S Lahoti et al.   ANNALS OF THE RHEUMATIC DISEASES

The emerging roles of AhR in physiology and immunity

(2013) Nan Hao et al.   BIOCHEMICAL PHARMACOLOGY

An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2

(2013) Jun Terashima et al.   BMC MOLECULAR BIOLOGY

An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells

(2013) Kai Wang et al.   CANCER LETTERS

Activation of the aryl hydrocarbon receptor by a component of cigarette smoke reduces germ cell proliferation in the human fetal ovary

(2013) R. A. Anderson et al.   MOLECULAR HUMAN REPRODUCTION

Synthetic and Natural Compounds that Interact with Human Cytochrome P450 1A2 and Implications in Drug Development

(2012) B. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways

(2012) Su Jung Oh et al.   ENDOCRINE-RELATED CANCER

The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones

(2012) Li Zhang et al.   Frontiers in Pharmacology

Sorafenib: activity and clinical application in patients with hepatocellular carcinoma

(2011) Yong-Song Guan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Fluoranthene enhances p53 expression and decreases mutagenesis induced by benzo[a]pyrene

(2011) Min-Cong Huang et al.   TOXICOLOGY LETTERS

Structural and functional insights into nuclear receptor signaling

(2010) Lihua Jin et al.   ADVANCED DRUG DELIVERY REVIEWS

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

(2010) Anthony E. Boitano et al.   SCIENCE

1-Nitropyrene Stabilizes the mRNA of Cytochrome P450 1a1, a Carcinogen-Metabolizing Enzyme, via the Akt Pathway

(2009) Wen-Cheng Chu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Crosstalk between activated forms of the aryl hydrocarbon receptor and glucocorticoid receptor

(2009) Shao-Hung Wang et al.   TOXICOLOGY

The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways

(2008) Alvaro Puga et al.   BIOCHEMICAL PHARMACOLOGY