T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese

Contact-independent killing mediated by a T6SS effector with intrinsic cell-entry properties

(2021) Li Song et al.   Nature Communications

T6SS secretes an LPS-binding effector to recruit OMVs for exploitative competition and horizontal gene transfer

(2021) Changfu Li et al.   ISME Journal

Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity

(2020) Lin Hou et al.   ACS Nano

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allosteric coupling between Mn2+ and dsDNA controls the catalytic efficiency and fidelity of cGAS

(2020) Richard M Hooy et al.   NUCLEIC ACIDS RESEARCH

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

Bacterial iron detoxification at the molecular level

(2020) Justin M. Bradley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensing of autoinducer-2 by functionally distinct receptors in prokaryotes

(2020) Lei Zhang et al.   Nature Communications

Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

(2020) Zhen Zhao et al.   Cell Reports

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

(2019) Yue Xu et al.   CELL

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

A Pseudomonas aeruginosa type VI secretion system regulated by CueR facilitates copper acquisition

(2019) Yuying Han et al.   PLoS Pathogens

Intracellular calcium is a rheostat for the STING signaling pathway

(2018) Dohyeong Kwon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Antagonism toward the intestinal microbiota and its effect onVibrio choleraevirulence

(2018) Wenjing Zhao et al.   SCIENCE

A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella

(2018) Hannah E. Ledvina et al.   Cell Host & Microbe

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

(2018) Ishita Banerjee et al.   IMMUNITY

Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins

(2018) See-Yeun Ting et al.   CELL

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

(2018) Sonal Srikanth et al.   NATURE IMMUNOLOGY

Manganese scavenging and oxidative stress response mediated by type VI secretion system inBurkholderia thailandensis

(2017) Meiru Si et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging Roles of STING in Bacterial Infections

(2017) Fabio V. Marinho et al.   TRENDS IN MICROBIOLOGY

Rules of Engagement: The Type VI Secretion System in Vibrio cholerae

(2017) Avatar Joshi et al.   TRENDS IN MICROBIOLOGY

A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition

(2017) Jinshui Lin et al.   Nature Communications

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation

(2016) Daniel F. Aubert et al.   Cell Host & Microbe

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration

(2016) Vladimir E. Diaz-Ochoa et al.   Cell Host & Microbe

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages

(2016) Ronan Kapetanovic et al.   FASEB JOURNAL

Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence

(2016) Taylor J. Schoberle et al.   INFECTION AND IMMUNITY

Functional Determinants of Metal Ion Transport and Selectivity in Paralogous Cation Diffusion Facilitator Transporters CzcD and MntE in Streptococcus pneumoniae

(2016) Julia E. Martin et al.   JOURNAL OF BACTERIOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Metal binding spectrum and model structure of the Bacillus anthracis virulence determinant MntA

(2015) Elena Vigonsky et al.   Metallomics

Differentin vitroexposure regimens of murine primary macrophages to silver nanoparticles induce different fates of nanoparticles and different toxicological and functional consequences

(2015) Catherine Aude-Garcia et al.   Nanotoxicology

Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity

(2015) Tietao Wang et al.   PLoS Pathogens

A Pseudomonas aeruginosa Type VI Secretion Phospholipase D Effector Targets Both Prokaryotic and Eukaryotic Cells

(2014) Feng Jiang et al.   Cell Host & Microbe

Zinc Signals Are Essential for Lipopolysaccharide-Induced Signal Transduction in Monocytes

(2014) H. Haase et al.   JOURNAL OF IMMUNOLOGY

Environmental manganese compounds accumulate as Mn(ii) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity

(2014) Asuncion Carmona et al.   Metallomics

Type VI secretion system effectors: poisons with a purpose

(2014) Alistair B. Russell et al.   NATURE REVIEWS MICROBIOLOGY

FliS modulates FlgM activity by acting as a non-canonical chaperone to control late flagellar gene expression, motility and biofilm formation inYersinia pseudotuberculosis

(2013) Shengjuan Xu et al.   ENVIRONMENTAL MICROBIOLOGY

Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates

(2013) Julie M. Silverman et al.   MOLECULAR CELL

The cGAS-STING Pathway for DNA Sensing

(2013) T. Sam Xiao et al.   MOLECULAR CELL

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases

(2013) Janina Schweer et al.   PLoS Pathogens

Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction

(2012) Ulrich Meinzer et al.   Cell Host & Microbe

A type VI secretion system regulated by OmpR inYersinia pseudotuberculosisfunctions to maintain intracellular pH homeostasis

(2012) Weipeng Zhang et al.   ENVIRONMENTAL MICROBIOLOGY

Battles with Iron: Manganese in Oxidative Stress Protection

(2012) J. Dafhne Aguirre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

(2010) Rachel D. Hood et al.   Cell Host & Microbe

Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages

(2010) Umesh C.S. Yadav et al.   FREE RADICAL BIOLOGY AND MEDICINE

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation

(2010) A. T. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

(2010) M. P. Muller et al.   SCIENCE

Targeting eEF1A by aLegionella pneumophilaeffector leads to inhibition of protein synthesis and induction of host stress response

(2009) Xihui Shen et al.   CELLULAR MICROBIOLOGY

Innate Immune Recognition of Yersinia pseudotuberculosis Type III Secretion

(2009) Victoria Auerbuch et al.   PLoS Pathogens