Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

DDR2 controls the epithelial-mesenchymal-transition-related gene expression via c-Myb acetylation upon matrix stiffening

(2017) Daehwan Kim et al.   Scientific Reports

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

(2016) Hua Gao et al.   CELL

Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression

(2016) Z Zelenko et al.   ONCOGENE

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis

(2016) Callie A.S. Corsa et al.   Cell Reports

Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer

(2015) Kathy A. Toy et al.   BREAST CANCER RESEARCH AND TREATMENT

High expression of DDR1 is associated with the poor prognosis in Chinese patients with pancreatic ductal adenocarcinoma

(2015) Yanmiao Huo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial-mesenchymal transition programme under hypoxia

(2014) Tingting Ren et al.   JOURNAL OF PATHOLOGY

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients

(2013) Tingting Ren et al.   MEDICAL ONCOLOGY

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression

(2013) Jonathan Chou et al.   NATURE CELL BIOLOGY

Discoidin domain receptor tyrosine kinases: new players in cancer progression

(2012) Rajeshwari R. Valiathan et al.   CANCER AND METASTASIS REVIEWS

Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis

(2012) K. Valencia et al.   CLINICAL CANCER RESEARCH

Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation

(2012) Huifang Xu et al.   PLoS One

Spatial organization of the extracellular matrix regulates cell-cell junction positioning

(2012) Q. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression

(2012) Laurie E. Littlepage et al.   Cancer Discovery

Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors

(2011) Brit Neuhaus et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization

(2011) E. M. Slorach et al.   GENES & DEVELOPMENT

In situ force mapping of mammary gland transformation

(2011) Jose I. Lopez et al.   Integrative Biology

Identification of Receptor Tyrosine Kinase, Discoidin Domain Receptor 1 (DDR1), as a Potential Biomarker for Serous Ovarian Cancer

(2011) Jinhua Quan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin

(2011) Yi-Chun Yeh et al.   MOLECULAR BIOLOGY OF THE CELL

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells

(2011) Richard Marcotte et al.   Cancer Discovery

Matrix Metalloproteinases Contribute Distinct Roles in Neuroendocrine Prostate Carcinogenesis, Metastasis, and Angiogenesis Progression

(2010) L. E. Littlepage et al.   CANCER RESEARCH

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production

(2010) M. E. Roberts et al.   EUROPEAN RESPIRATORY JOURNAL

DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation

(2010) Rajalakshmanan Eswaramoorthy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Collective cell migration requires suppression of actomyosin at cell–cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6

(2010) Cristina Hidalgo-Carcedo et al.   NATURE CELL BIOLOGY

Keratins in health and cancer: more than mere epithelial cell markers

(2010) V Karantza   ONCOGENE

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition

(2008) Michiko Maeyama et al.   CANCER

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

(2008) Andrew J. Ewald et al.   DEVELOPMENTAL CELL