Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Yanli Li, Yang Tian, Wei Zhong, Ning Wang, Yafeng Wang, Yan Zhang, Zhuangli Zhang, Jianbo Li, Fang Ma, Zhihong Zhao, Youmei Peng
Summary: The study revealed that Artemisia argyi essential oil (AAEO) effectively inhibits HCC metastasis by targeting DEPDC1, showing significant anti-metastatic effects with low toxicity in vivo.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xingming Zhao, Zhuo Han, Jiahui Ma, Shiqing Jiang, Xia Li
Summary: The study investigated a novel N-sulfonylamidine derivative 26ag in suppressing CRC cell proliferation and migration, revealing its strong anti-cancer activity by inhibiting C-met and reducing expression of hallmarks associated with EMT, involving the β-catenin-dependent pathway. This research demonstrates the potential of 26ag as a promising drug candidate for the therapy of CRC by inhibiting the Wnt/β-catenin pathway.
Article
Oncology
Yanqiu Bao, Jingshu Cui, Yuyang Yue, Shuxia Cao, Xiangdan Li, Lan Liu
Summary: Ebp1 is highly expressed in malignant melanoma and is associated with clinical stage and lymph node metastases. Knockdown of Ebp1 inhibits cell proliferation, migration, and invasion in melanoma. Ebp1 may promote the proliferation and metastasis of melanoma cells through activation of the Wnt/β-catenin pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Weijia Zhang, Chang Peng, Xue Shen, Yuemei Yuan, Wei Zhang, Chunjuan Yang, Meicun Yao
Summary: Colorectal cancer (CRC) is a common cancer worldwide, with 5-fluorouracil (5-FU) being the main chemotherapeutic agent. However, drug resistance to 5-FU is becoming a challenge, and natural products like Sanguisorba officinalis L. are being explored for potential solutions. The triterpenoid compound AGE extracted from this herb showed strong anti-CRC effects by inducing apoptosis, autophagy, and cell cycle arrest through the Wnt signaling pathway.
Article
Reproductive Biology
Li-Na Gao, Man Hao, Xiao-Hui Liu, Li Zhang, Yan Dong, Yu-Fang Zhang, Xiao-Chun He
Summary: This study demonstrated that high levels of CXCL14 were associated with a worse prognosis in patients with ovarian cancer. CXCL14 contributes to ovarian cancer cell growth and metastasis by regulating the Wnt/β-catenin signaling pathway.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Pathology
Rong Lu, Peipei Tang, Di Zhang, Sen Lin, Hong Li, Xian Feng, Meiling Sun, Hong Zhang
Summary: This study investigates the role of SOX9 in ovarian cancer and its potential molecular mechanisms. The results show that high expression of SOX9 is correlated with poor prognosis and various aggressive features of ovarian cancer. Knockdown of SOX9 inhibits migration and invasive ability of ovarian cancer cells, while overexpression has the opposite effect. Additionally, SOX9 promotes tumor metastasis by upregulating NFIA and activating the Wnt/β-catenin signaling pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Zhenyou Feng, Huiming Ding, Zhiwei Peng, Kongwang Hu
Summary: This study investigated the relationship between KDM6A expression and patient prognosis, as well as the role of KDM6A in GC development. Immunohistochemical analysis of 107 GC patients' tumors revealed that reduced KDM6A expression was associated with shorter survival time. In vitro tests showed that KDM6A gene suppression inhibited GC cell proliferation, migration, and invasion, while high KDM6A expression promoted these processes. The study also found that KDM6A down-regulation affected the expression of various proteins involved in Wnt/beta-catenin signaling and EMT, and blocking this pathway reversed the aggressive behavior of low KDM6A-expressing GC cells.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Environmental Sciences
Yangyang Tian, Jiarui Xia, Guo Yang, Chao Li, Yuanmeng Qi, Kai Dai, Chenchen Wu, Yonghua Guo, Wu Yao, Changfu Hao
Summary: We found that A2aR inhibits fibrosis and the EMT process in silicosis by regulating the Wnt/β-catenin pathway. Our study provides an experimental basis for elucidating the role of A2aR in the development of silicosis and offers new ideas for further exploration of interventions for silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biotechnology & Applied Microbiology
Tao Xueqin, Mei Jinhong, Huang Yuping
Summary: INHBA is highly expressed in breast cancer cells and acts as an oncogene by activating the Wnt/beta-catenin pathway, providing a potential therapeutic target for the treatment of breast cancer.
Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Cell Biology
Yanlin Cai, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Shunliang Sheng, Jiayu Zhu
Summary: Globally, ovarian cancer ranks as the second most common cause of gynecologic-related cancer deaths among women, with a poor prognosis. Research has shown that downregulation of AHNAK in ovarian cancer cells can significantly inhibit cell growth and metastasis, partly by dampening the Canonical Wnt cascade. Therefore, AHNAK may serve as a biomarker and potential treatment target for ovarian cancer.
Article
Oncology
Qingchao Meng, Lei Li, Liping Wang
Summary: This study found that CBX8 is highly expressed in laryngeal squamous cell carcinoma (LSCC), and it induces the epithelial to mesenchymal transition (EMT) process by activating the Wnt/β-catenin signaling pathway, promoting LSCC cell proliferation and migration, and inhibiting apoptosis, resulting in poor prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yin Peng, Xiaojing Zhang, Huijuan Lin, Shiqi Deng, Ying Qin, Jieqiong He, Fan Hu, Xiaohui Zhu, Xianling Feng, Jian Wang, Yanjie Wei, Xinmin Fan, Huan Lin, Hassan Ashktorab, Duane Smoot, Yansi Lv, Song Li, Stephen J. Meltzer, Zhe Jin
Summary: Mounting evidence suggests that miRNA-150 upregulation in gastric cancer promotes cell proliferation, migration, and EMT by targeting the tumor suppressor SUFU and activating Hedgehog and Wnt signaling. Inhibition of miRNA-150 shows promise in reducing tumor volume by suppressing Wnt and Hh signaling pathways.
Article
Cell Biology
Qiong Zhong, Qihong Nie, Renrui Wu, Yun Huang
Summary: This study investigated the mechanism of miR-18a-5p in regulating the proliferation, invasion, and metastasis of nasopharyngeal carcinoma (NPC) cells. It was found that exosomal miR-18a-5p secreted from NPC cells promoted NPC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). The target gene of miR-18a-5p was identified as BTG anti-proliferation factor 3 (BTG3), and BTG3 could reverse the effects of miR-18a-5p on NPC cells. Moreover, in vivo experiments confirmed that miR-18a-5p promoted NPC growth and metastasis.
Article
Environmental Sciences
Dapeng Li, Lilong Jiang, Yanjun Hong, Zongwei Cai
Summary: The study explored the impact of PFOS exposure on protein glycosylation in mouse livers, revealing dysregulated proteins involved in lipid and xenobiotic metabolism, as well as overexpressed glycoproteins related to neutrophil degranulation, stress responses, and protein processing in the endoplasmic reticulum. The identified potential glycoprotein biomarkers, HP and HSP90AA1, provide insights into understanding PFOS-induced hepatotoxicity and liver disease, demonstrating the applicability of multilayered glycoproteomics in ecotoxicological research.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Jinghui Zhang, Yanjun Hong, Peisi Xie, Yang Chen, Lilong Jiang, Zhiyi Yang, Guodong Cao, Zhongjian Chen, Xuesong Liu, Yong Chen, Yongjiang Wu, Zongwei Cai
Summary: The combination treatment with Bufalin and cinobufagin showed superior anticancer efficacy by modulating sphingolipid metabolism and glycerophospholipid metabolism, leading to mitochondria-driven apoptosis and disruption of biomembranes in tumor cells. Disturbed lipid markers were mainly located in non-necrotic tumor areas, essential for solid tumor framework formation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Jiahui Yan, Chang Peng, Pengting Chen, Weijia Zhang, Cheng Jiang, Shuyi Sang, Weixing Zhu, Yuemei Yuan, Yanjun Hong, Meicun Yao
Summary: The study found that extracts from Canarium album Raeusch. exhibited activity to inhibit the growth of H. pylori, destroy bacterial structure, and down-regulate the expression of virulence factors, suggesting its potential as an alternative treatment for H. pylori infection.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Zhandong Yang, Xuzi Cai, Xiaoxia Xu, Zengmei Xu, Simin Ye, Yan Wang, Yanjun Hong, Baochun Shen, Qiongfeng Liao, Zhiyong Xie, Xuefeng Wang
Summary: This study revealed metabolic disturbances associated with polycystic ovary syndrome (PCOS) using urinary metabolomics. By combining quantitative analysis and enrichment analysis, metabolic pathways related to PCOS, especially glycerophospholipid metabolism and tryptophan metabolism, were identified. Additionally, seven tryptophan-kynurenine metabolites were found to be up-regulated in PCOS and showed significant correlations with PCOS clinical features.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Plant Sciences
Chang Peng, Shuyi Sang, Xue Shen, Weijia Zhang, Jiahui Yan, Pengting Chen, Cheng Jiang, Yuemei Yuan, Weixing Zhu, Meicun Yao
Summary: This study aimed to investigate the antibacterial activities of S. aromaticum extracts on H. pylori strains, both sensitive and resistant to antibiotics. The extracts demonstrated significant antibacterial effects, altering bacterial structure, decreasing virulence gene expression, and interfering with metabolic pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Ying Cai, Siju Li, Xiaojun Zhang, Xueqin Cao, Deliang Liu, Yanglu Zhu, Simin Ye, Zengmei Xu, Qiongfeng Liao, Yanjun Hong, Zhiyong Xie
Summary: This study revealed that ZJW could alleviate DSS-induced UC in rats by modulating the interaction between gut microbiota and host cometabolites.
Article
Oncology
Weijia Zhang, Shuyi Sang, Chang Peng, George Q. Li, Ling Ou, Zhong Feng, Yuanjing Zou, Yuemei Yuan, Meicun Yao
Summary: This study used network pharmacology and transcriptomic sequencing methods to explore the mechanism of Sanguisorba officinalis against colorectal cancer (CRC) cells. The results showed that S. officinalis suppresses the proliferation, survival, and migration of CRC cells by regulating the PI3K-Akt, HIF-1, and MAPK signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jiayin Yu, Zhihao Guo, Jiachang Yan, Changxin Bu, Chang Peng, Cuie Li, Rui Mao, Jian Zhang, Zhi Wang, Shi Chen, Meicun Yao, Zhiyong Xie, Chuan Yang, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: This study reports a pH-responsive ROS nanogenerator composed of an acid-responsive metal polyphenol network (MPN) shell and a mesoporous metal-organic nanostructure core (Fe-HMME). The nanogenerators generate more ROS singlet oxygen than HMME under ultrasonication, fueled by oxygen generated through Fenton/Fenton-like reactions in the infection microenvironment. They show high therapeutic efficacy in killing multidrug-resistant H. pylori and removing biofilm, with negligible side effects on the normal gut microbiota. These self-enhanced ROS nanogenerators have great potential for H. pylori infection treatment.
Article
Multidisciplinary Sciences
Weijia Zhang, Ling Ou, Chang Peng, Shuyi Sang, Zhong Feng, Yuanjing Zou, Yuemei Yuan, Hao Li, Guimin Zhang, Meicun Yao
Summary: Sanguisorba officinalis L., a traditional Chinese medicine, can improve the sensitivity of 5-FU-resistant CRC cells and inhibit their proliferation and migration. It may overcome chemoresistance through the Ras/MEK/ERK and PI3K/Akt pathways.
Article
Food Science & Technology
Chang Peng, Zhong Feng, Ling Ou, Yuanjing Zou, Shuyi Sang, Hengrui Liu, Weixing Zhu, Guoxing Gan, Guimin Zhang, Meicun Yao
Summary: This study found that Syzygium aromaticum aqueous extract (AE) can enhance innate immunity by activating TLR4/MyD88-mediated NF-κB and MAPK pathways, blocking Nrf2/HO-1 signaling, promoting macrophage M1 polarization, and reducing inflammation caused by Helicobacter pylori infection. Syzygium aromaticum, as an edible herbal medicine with immune-enhancing activity and good safety, deserves further research and utilization for treating H. pylori infection-related disorders.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.