Article
Biochemistry & Molecular Biology
Jie Wang, Jun Hu, Mingyun Wang, Huaqin Yuan, Yajun Xing, Xiaohua Zhou, Meiqing Ding, Wenqiang Chen, Baoqi Qu, Liangxue Zhu
Summary: This study investigates the role of CDGSH iron-sulfur domain 2 (CISD2) in colorectal cancer (CRC). The study found that CISD2 promotes tumor cell proliferation and inhibits apoptosis and autophagy in CRC. Furthermore, it was discovered that inhibiting CISD2 suppresses the activation of the Wnt/β-Catenin signaling pathway and inhibits tumor growth.
BIOCHEMICAL GENETICS
(2023)
Article
Agriculture, Multidisciplinary
Hui Zhao, Shun Tang, Qiu Tao, Tianqi Ming, Jiarong Lei, Yuanjing Liang, Yuhui Peng, Minmin Wang, Maolun Liu, Han Yang, Shan Ren, Haibo Xu
Summary: Overwhelming evidence supports the role of the Wnt/beta-catenin signaling pathway in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and plants, has shown potent anticancer activity against CRC, although its mechanism of action is not fully understood. This study aimed to investigate the effects of UA on CRC and its impact on the Wnt/beta-catenin signaling pathway. The study demonstrated that UA significantly inhibited proliferation, migration, and clonality, induced apoptosis, and arrested the cell cycle in CRC cells. Moreover, UA suppressed tumor growth, improved pathological features, induced apoptosis, and arrested the cell cycle in CRC tissue, by diminishing the Wnt/beta-catenin signaling pathway. These findings suggest that UA has the potential to inhibit the malignant phenotype of CRC by attenuating the Wnt/beta-catenin signaling axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Biochemistry & Molecular Biology
Qinmei Ma, Jialin Yu, Xu Zhang, Xiaoling Wu, Guangcun Deng
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in cell development, proliferation, differentiation, apoptosis and autophagy. The interplay between Wnt/β-catenin-regulated apoptosis and autophagy is of significant functional importance in various diseases. This article summarizes the recent studies on the role of the Wnt/β-catenin signaling pathway in apoptosis and autophagy, and draws the following conclusions: a) Wnt/β-catenin generally has a positive regulatory role in apoptosis, but there is also evidence of a negatively regulated relationship; b) Wnt/β-catenin influences the occurrence and development of autophagy by regulating autophagy-related factors, and these factors in turn affect the Wnt/β-catenin pathway; c) Wnt/β-catenin always balances the molecular damage caused by the crosstalk between autophagy and apoptosis in a compensatory manner. Understanding the specific role of the Wnt/β-catenin signaling pathway during different stages of autophagy and apoptosis may provide new insights into the progression of related diseases regulated by this pathway.
Article
Oncology
Hiroki Tage, Kiyoshi Yamaguchi, Saya Nakagawa, So Kasuga, Kiyoko Takane, Yoichi Furukawa, Tsuneo Ikenoue
Summary: In this study, novel target genes of the Wnt/β-catenin signaling pathway were identified in cancer cells. One of these genes, Visinin-like 1 (VSNL1), was found to be regulated by the β-catenin/TCF7L2 complex via TCF7L2-binding elements and involved in apoptosis resistance in colorectal cancer cells.
Article
Pharmacology & Pharmacy
Tianye Li, Zihan Tang, Chunting Li, Xiaoya Liu, Linglin Cheng, Zhijing Yang, Xiaojin Zhu, Weiwei Liu, Yongye Huang
Summary: This study found that co-treatment with cisplatin and magnesium chloride (MgCl2) reduced the survival rate and colony formation of bladder cancer cells. The combination therapy also increased the proportion of apoptotic cells. Magnesium was shown to moderately regulate the Wnt/β-catenin signaling pathway, enhancing the efficacy of cisplatin-based chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Liang Zhang, Chuan-fu Ren, Zhi Yang, Long-bo Gong, Chao Wang, Min Feng, Wen-xian Guan
Summary: FOXS1 plays a role in promoting cell proliferation, migration, invasion, and metastasis in colorectal cancer through the Wnt/beta-catenin signaling pathway, making it a potential target for CRC treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yujing Liu, Chunyan Wang, Peiqiu Cheng, Shengan Zhang, Wenjun Zhou, Yangxian Xu, Hanchen Xu, Guang Ji
Summary: This study found that low FHL1 expression is associated with poor patient survival in colorectal cancer. Experimental results indicate that FHL1 acts as a tumor suppressor in CRC, primarily by inhibiting cell proliferation through regulating the Wnt/beta-catenin signaling pathway.
Article
Oncology
Wulin Shan, Chunyang Dai, Huanhuan Zhang, Dan Han, Qiyi Yi, Bairong Xia
Summary: This study found that downregulation of ACY1 could enhance the radiosensitivity of cetuximab-resistant CRC by inactivating the Wnt/β-catenin signaling pathway. These findings suggest that ACY1 may serve as a potential radiotherapy target for cetuximab-resistant CRC.
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Article
Cell Biology
Xiaolong Tang, Yahang Liang, Guorui Sun, Qingsi He, Hui Qu, Peng Gao
Summary: UBQLN4, a key member of the ubiquitin-like protein family, is upregulated in CRC tissues and associated with tumor size, stage, and metastasis. Its overexpression promotes CRC cell proliferation, migration, and invasion through activation of the Wnt/beta-catenin pathway and C/EBP beta transcriptional activation. Targeting UBQLN4 may hold promise for the diagnosis and treatment of CRC patients.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Biochemistry & Molecular Biology
Min Hee Yang, In Jin Ha, Seok-Geun Lee, Junhee Lee, Jae-Young Um, Kwang Seok Ahn
Summary: Ginkgolide C (GGC) inhibits the Wnt/beta-catenin signaling pathway, reduces the expression of beta-catenin and downstream signals, and suppresses proliferation, invasion, and migration of colon cancer cells while inducing apoptosis.
Article
Plant Sciences
Jiahui Yan, Chang Peng, Pengting Chen, Weijia Zhang, Cheng Jiang, Shuyi Sang, Weixing Zhu, Yuemei Yuan, Yanjun Hong, Meicun Yao
Summary: The study found that extracts from Canarium album Raeusch. exhibited activity to inhibit the growth of H. pylori, destroy bacterial structure, and down-regulate the expression of virulence factors, suggesting its potential as an alternative treatment for H. pylori infection.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Fei-Long Chen, Dong-Li Liu, Jing Fu, Ji Yang, Li-Ping Bai, Wei Zhang, Zhi-Hong Jiang, Guo-Yuan Zhu
Summary: Atrachinenins A-C (1-3), isolated from the rhizomes of Atractylodes chinensis, are meroterpenoids with novel C-27 skeletons. Atrachinenin A (1) features a unique cage-like skeleton, while atrachinenin B (2) has an additional peroxyl bridge ring, forming a complex cyclic ring system. Structural elucidation was done through various spectroscopic techniques and a plausible biosynthetic pathway was proposed. Atrachinenin A exhibited potential TGF-beta inhibitory activity at 25 μmol/L.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Weijia Zhang, Chang Peng, Jiahui Yan, Pengting Chen, Cheng Jiang, Shuyi Sang, Yuemei Yuan, Yanjun Hong, Meicun Yao
Summary: This study demonstrated that the aqueous extract of Sanguisorba officinalis Linn. could inhibit the growth and metastasis of colorectal cancer cells by suppressing the Wnt pathway, providing potential for clinical application as an anti-CRC drug.
Article
Electrochemistry
Yue Wang, Xuan Wu, Jianfeng Sun, Caiyun Wang, Guoyuan Zhu, Li-Ping Bai, Zhi-Hong Jiang, Wei Zhang
Summary: In this study, a novel bismuth oxide surface-decorated nanoporous bismuth (Bi2O3@NPBi) was prepared, which showed high cycling stability and capacity for sensitive detection of heavy metal ions with little interference from co-existing ions.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Plant Sciences
Chang Peng, Shuyi Sang, Xue Shen, Weijia Zhang, Jiahui Yan, Pengting Chen, Cheng Jiang, Yuemei Yuan, Weixing Zhu, Meicun Yao
Summary: This study aimed to investigate the antibacterial activities of S. aromaticum extracts on H. pylori strains, both sensitive and resistant to antibiotics. The extracts demonstrated significant antibacterial effects, altering bacterial structure, decreasing virulence gene expression, and interfering with metabolic pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mingyue Zhou, Xuan Wu, Yan Li, Huixia Zhang, Qinghua Liu, Linlin Song, Caiyun Wang, Betty Yuen Kwan Law, Zhihong Jiang, Wei Zhang
Summary: Alzheimer's disease is a neurodegenerative disease associated with aging, characterized by the deposition of abnormally phosphorylated tau filaments and amyloid beta-peptides fibrils. In this study, atomic zinc sites were used to screen potential inhibitors of A beta aggregation in turmeric. The developed method shows promise for efficient drug discovery from natural product resources.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Qian-Bao Liu, Jing-Guang Lu, Zhi-Hong Jiang, Wei Zhang, Wen-Jia Li, Zheng-Ming Qian, Li-Ping Bai
Summary: Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a sensitive surface analytical technology that allows for simultaneous acquisition of diverse chemical components and their precise locations on the surfaces of samples. In this study, a new sample preparation strategy was developed to perform in situ chemical analysis of Cordyceps sinensis using TOF-SIMS. The technique was successfully applied to compare natural and cultured Cordyceps sinensis, revealing important differences in their chemical distributions. Overall, TOF-SIMS is considered an advanced and promising analytical technology for the research of traditional Chinese medicines.
FRONTIERS IN CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Mingyue Zhou, Yan Li, Chuanjin Huang, Cairen Wang, Qinghua Liu, Qibo Deng, Huixia Zhang, Tianpeng Yin, Guoyuan Zhu, Caiyun Wang, Yunfeng Zhao, Wei Zhang
Summary: Carbon nanomaterials, particularly graphene oxide (GO), have great potential in materials science and biomedicine. However, GO lamelayers tend to aggregate and are difficult to disperse in solution, resulting in low loading efficiency. To address this issue, oriented layered graphene oxide pad (OGO) was synthesized as a carrier to improve loading capacity and stability. The OGO structure showed good reproducibility and recyclability, with open channels and low pore curvature for better flow and higher fishing sites density. The CMP@OGO achieved 1.5 to 2 times higher loading capacity compared to GO. Moreover, the established CMP@OGO exhibited stability and high reuse rate, making it a promising platform for active compound screening.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Analytical
Hui-Xia Zhang, Jian-Feng Qin, Jian-Feng Sun, Yu Pan, Tong-Meng Yan, Cai-Yun Wang, Li-Ping Bai, Guo-Yuan Zhu, Zhi-Hong Jiang, Wei Zhang
Summary: Despite the challenges posed by macromolecular nucleic acids, a recent labeling method using N-(tert-butyldimethylsilyl)-N-methyl-trifluoroacetamide (MTBSTFA) has shown promise in the profiling and characterization of DNA and RNA. This method offers advantages such as strong retention, predictable MS2 data, and avoidance of harmful reagents. It has been successfully applied to the analysis of tRNA, including the detection of modified bases and the discovery of new modifications. The ease of access and simplicity of this method make it a valuable tool for researchers.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Qing-Hua Liu, Yu-Dong Zhang, Zhang-Wen Ma, Zheng-Ming Qian, Zhi-Hong Jiang, Wei Zhang, Liang Wang
Summary: Ophiocordyceps sinensis is a valuable medicinal fungus used in traditional Chinese medicine, with polysaccharides as key constituents. This study confirmed that the polysaccharides extracted from the cultivated fungus were mostly glycogen.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Jiayin Yu, Zhihao Guo, Jiachang Yan, Changxin Bu, Chang Peng, Cuie Li, Rui Mao, Jian Zhang, Zhi Wang, Shi Chen, Meicun Yao, Zhiyong Xie, Chuan Yang, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: This study reports a pH-responsive ROS nanogenerator composed of an acid-responsive metal polyphenol network (MPN) shell and a mesoporous metal-organic nanostructure core (Fe-HMME). The nanogenerators generate more ROS singlet oxygen than HMME under ultrasonication, fueled by oxygen generated through Fenton/Fenton-like reactions in the infection microenvironment. They show high therapeutic efficacy in killing multidrug-resistant H. pylori and removing biofilm, with negligible side effects on the normal gut microbiota. These self-enhanced ROS nanogenerators have great potential for H. pylori infection treatment.
Article
Multidisciplinary Sciences
Weijia Zhang, Ling Ou, Chang Peng, Shuyi Sang, Zhong Feng, Yuanjing Zou, Yuemei Yuan, Hao Li, Guimin Zhang, Meicun Yao
Summary: Sanguisorba officinalis L., a traditional Chinese medicine, can improve the sensitivity of 5-FU-resistant CRC cells and inhibit their proliferation and migration. It may overcome chemoresistance through the Ras/MEK/ERK and PI3K/Akt pathways.
Article
Food Science & Technology
Chang Peng, Zhong Feng, Ling Ou, Yuanjing Zou, Shuyi Sang, Hengrui Liu, Weixing Zhu, Guoxing Gan, Guimin Zhang, Meicun Yao
Summary: This study found that Syzygium aromaticum aqueous extract (AE) can enhance innate immunity by activating TLR4/MyD88-mediated NF-κB and MAPK pathways, blocking Nrf2/HO-1 signaling, promoting macrophage M1 polarization, and reducing inflammation caused by Helicobacter pylori infection. Syzygium aromaticum, as an edible herbal medicine with immune-enhancing activity and good safety, deserves further research and utilization for treating H. pylori infection-related disorders.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Multidisciplinary
Lingkai Kong, Jieru Meng, Wenyue Tian, Jiazheng Liu, Xueping Hu, Zhi-Hong Jiang, Wei Zhang, Yanzhong Li, Li-Ping Bai
Summary: An efficient approach for the synthesis of 1,2-diaryl diketones was developed from readily available alpha-methylene ketones by catalysis of I-2. In the same oxidation system, a novel one-pot procedure was established for the construction of antiviral and anticancer quinoxalines, showing good functional group tolerance with moderate to excellent yields. The synthesized compounds exhibited inhibitory effects on viral entry and cytotoxicity against cancer cells.
