Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice

Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway

(2021) Yaping Xiao et al.   PHYTOMEDICINE

Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation

(2020) Chih-Chung Lin et al.   Journal of Clinical Medicine

Chronic kidney disease in type 2 diabetes: Implications for managing glycaemic control, cardiovascular and renal risk

(2020) Jeffrey W. Stephens et al.   DIABETES OBESITY & METABOLISM

Genetics of diabetes mellitus and diabetes complications

(2020) Joanne B. Cole et al.   Nature Reviews Nephrology

Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway

(2020) Fengtao Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tangshen formula modulates gut Microbiota and reduces gut-derived toxins in diabetic nephropathy rats

(2020) TingTing Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Baicalin reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal injury in type 1 diabetic mouse model

(2020) Xiao-Tan Zhang et al.   CELL CYCLE

Explore of the beneficial effects of Huang-Lian-Jie-Du Decoction on diabetic encephalopathy in db/db mice by UPLC-Q-Orbitrap HRMS/MS based untargeted metabolomics analysis

(2020) Wen-Jiao He et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes

(2020) Yan Yang et al.   PHARMACOLOGICAL RESEARCH

Rapid characterization of the absorbed constituents in rat serum after oral administration and action mechanism of Naozhenning granule using LC-MS and network pharmacology

(2019) Shuting Yu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications and other age-related diseases

(2019) Casper Schalkwijk et al.   PHYSIOLOGICAL REVIEWS

Micheliolide ameliorates diabetic kidney disease by inhibiting Mtdh-mediated renal inflammation in type 2 diabetic db/db mice

(2019) Wenting Liu et al.   PHARMACOLOGICAL RESEARCH

Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

(2019) Yiyu Qi et al.   Chinese Medicine

Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes

(2018) Alexandra Moraru et al.   Cell Metabolism

Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways

(2018) Hailong Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Carnosic acid improves diabetic nephropathy by activating Nrf2/ARE and inhibition of NF-κB pathway

(2018) Zhisheng Xie et al.   PHYTOMEDICINE

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

(2018) Jyotiska Chaudhuri et al.   Cell Metabolism

Tea Polypeptide Ameliorates Diabetic Nephropathy through RAGE and NF-κB Signaling Pathway in Type 2 Diabetes Mice

(2018) Xuming Deng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Improved dialysis removal of protein-bound uremic toxins by salvianolic acids

(2018) Jianping Li et al.   PHYTOMEDICINE

Comparative study of single/combination use of Huang-Lian-Jie-Du decoction and berberine on their protection on sepsis induced acute liver injury by NMR metabolic profiling

(2017) Yan Lv et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Modelling diabetic nephropathy in mice

(2017) Kengo Azushima et al.   Nature Reviews Nephrology

Deciphering the mechanism of Huang-Lian-Jie-Du-Decoction on the treatment of sepsis by formula decomposition and metabolomics: Enhancement of cholinergic pathways and inhibition of HMGB-1/TLR4/NF-κB signaling

(2017) Dingqiao Xu et al.   PHARMACOLOGICAL RESEARCH

Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential

(2017) Alyssa Faria et al.   PHARMACOLOGY & THERAPEUTICS

Synergistic interaction of effective parts in Rehmanniae Radix and Cornus officinalis ameliorates renal injury in C57BL/KsJ-db/db diabetic mice: Involvement of suppression of AGEs/RAGE/SphK1 signaling pathway

(2016) Xing Lv et al.   JOURNAL OF ETHNOPHARMACOLOGY

p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

(2013) Hiroshi Watanabe et al.   KIDNEY INTERNATIONAL