Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway

Contribution of TGF-β1 and Effects of Gene Silencer Pyrrole-Imidazole Polyamides Targeting TGF-β1 in Diabetic Nephropathy

(2020) Shu Horikoshi et al.   MOLECULES

Targeting angiogenesis and lymphangiogenesis in kidney disease

(2020) Katsuyuki Tanabe et al.   Nature Reviews Nephrology

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

(2020) Lucas Opazo-Ríos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of miRNA‑135a‑5p ameliorates TGF‑β1‑induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy

(2020) Juan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Biologically active isoquinoline alkaloids covering 2014–2018

(2020) Xiao‐Fei Shang et al.   MEDICINAL RESEARCH REVIEWS

Human blood vessel organoids as a model of diabetic vasculopathy

(2019) Reiner A. Wimmer et al.   NATURE

Nonproteinuric Versus Proteinuric Phenotypes in Diabetic Kidney Disease: A Propensity Score–Matched Analysis of a Nationwide, Biopsy-Based Cohort Study

(2019) Masayuki Yamanouchi et al.   DIABETES CARE

The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine

(2019) Hang Ma et al.   FITOTERAPIA

Stachydrine Ameliorates Cardiac Fibrosis Through Inhibition of Angiotensin II/Transformation Growth Factor β1 Fibrogenic Axis

(2019) Xiao Liu et al.   Frontiers in Pharmacology

Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies

(2019) Annabelle M. Warren et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Quercetin inhibited mesangial cell proliferation of early diabetic nephropathy through the Hippo pathway

(2019) Du Lei et al.   PHARMACOLOGICAL RESEARCH

Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice

(2019) Chao Zheng et al.   Cell Death & Disease

Carnosic acid improves diabetic nephropathy by activating Nrf2/ARE and inhibition of NF-κB pathway

(2018) Zhisheng Xie et al.   PHYTOMEDICINE

Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation

(2018) Hua Chen et al.   PHYTOMEDICINE

Diagnosis of diabetic kidney disease: state of the art and future perspective

(2018) Frederik Persson et al.   Kidney International Supplements

Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type2 diabetes

(2018) Tsuneo Takenaka et al.   Acta Physiologica

Epiberberine, a natural protoberberine alkaloid, inhibits urease of Helicobacter pylori and jack bean: Susceptibility and mechanism

(2017) Lihua Tan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway

(2017) Ming Wang et al.   PHYTOMEDICINE

The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation

(2017) Ning Chen et al.   Drug Design Development and Therapy

Mechanistic Insight and Management of Diabetic Nephropathy: Recent Progress and Future Perspective

(2017) Rui Xue et al.   Journal of Diabetes Research

The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats

(2017) Sebastian Steven et al.   Redox Biology

Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis

(2016) Huiyan Li et al.   Autophagy

Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice

(2016) Hang Ma et al.   DRUG DEVELOPMENT RESEARCH

Epiberberine reduces serum cholesterol in diet-induced dyslipidemia Syrian golden hamsters via network pathways involving cholesterol metabolism

(2016) Zong-Yao Zou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats

(2016) O Jun Kwon et al.   Evidence-based Complementary and Alternative Medicine

Tetrahydrobiopterin contributes to the proliferation of mesangial cells and accumulation of extracellular matrix in early-stage diabetic nephropathy

(2016) Jianyun Wang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Comprehensive evaluation of ten docking programs on a diverse set of protein–ligand complexes: the prediction accuracy of sampling power and scoring power

(2016) Zhe Wang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Hypolipidemic Effects of Alkaloids from Rhizoma Coptidis in Diet-Induced Hyperlipidemic Hamsters

(2016) Kai He et al.   PLANTA MEDICA

Chinese medicines in the treatment of experimental diabetic nephropathy

(2016) Jing-Yi Liu et al.   Chinese Medicine

Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways

(2015) Jae Sue Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Catalase Overexpression Prevents Nuclear Factor Erythroid 2-Related Factor 2 Stimulation of Renal Angiotensinogen Gene Expression, Hypertension, and Kidney Injury in Diabetic Mice

(2014) S. Abdo et al.   DIABETES

Diabetic nephropathy: diagnosis and treatment

(2013) Daniel Fineberg et al.   Nature Reviews Endocrinology

Safety evaluation of main alkaloids from Rhizoma Coptidis

(2012) Jun Yi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells

(2011) Hong-Ying Chen et al.   FITOTERAPIA

Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes

(2011) Hermann Haller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of polyunsaturated fatty acid consumption in diabetic nephropathy

(2010) Haim Shapiro et al.   Nature Reviews Nephrology

Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids

(2009) Hyun Ah Jung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN