Synthetic lethality theory approaches to effective substance discovery and functional mechanisms elucidation of anti-cancer phytomedicine

Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors

(2021) Stephane Angers   EMBO Molecular Medicine

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

(2021) Kasper Fugger et al.   SCIENCE

Quantitative analysis of sesquiterpenes and comparison of three Curcuma wenyujin herbal medicines by micro matrix solid phase dispersion coupled with MEEKC

(2018) Mengmeng Wei et al.   ELECTROPHORESIS

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

(2018) Ilirjana Bajrami et al.   Cancer Discovery

Biocidal effects of Piper hispidinervum (Piperaceae) essential oil and synergism among its main components

(2017) M.F. Andrés et al.   FOOD AND CHEMICAL TOXICOLOGY

A comprehensive in vitro and in vivo metabolism study of hydroxysafflor yellow A

(2017) Liang Wu et al.   JOURNAL OF MASS SPECTROMETRY

Restricted Delivery of Talazoparib Across the Blood–Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma

(2017) Sani H. Kizilbash et al.   MOLECULAR CANCER THERAPEUTICS

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

(2017) Kyuho Han et al.   NATURE BIOTECHNOLOGY

Synthetic lethality screens point the way to new cancer drug targets

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Marked for death: targeting epigenetic changes in cancer

(2017) Sophia Xiao Pfister et al.   NATURE REVIEWS DRUG DISCOVERY

Synthetic lethality and cancer

(2017) Nigel J. O'Neil et al.   NATURE REVIEWS GENETICS

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

(2017) Parker L. Sulkowski et al.   Science Translational Medicine

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

Re: DNA-repair Defects and Olaparib in Metastatic Prostate Cancer

(2016) Wim P.J. Witjes   EUROPEAN UROLOGY

A combination of the main constituents of Fufang Xueshuantong Capsules shows protective effects against streptozotocin-induced retinal lesions in rats

(2016) Weijie Jian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

(2016) Mansoor R. Mirza et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic engineering of proanthocyanidin production by repressing the isoflavone pathways and redirecting anthocyanidin precursor flux in legume

(2016) Penghui Li et al.   PLANT BIOTECHNOLOGY JOURNAL

The SnRK1 Energy Sensor in Plant Biotic Interactions

(2016) Sander Hulsmans et al.   TRENDS IN PLANT SCIENCE

New strategy for drug discovery by large-scale association analysis of molecular networks of different species

(2016) Bo Zhang et al.   Scientific Reports

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells

(2015) M. Kwok et al.   BLOOD

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

(2015) Giovanni Ciriello et al.   CELL

Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway

(2015) Marwan Kwok et al.   LANCET

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

(2015) Joaquin Mateo et al.   NEW ENGLAND JOURNAL OF MEDICINE

ATM and ATR as therapeutic targets in cancer

(2015) Anika Maria Weber et al.   PHARMACOLOGY & THERAPEUTICS

Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma

(2015) F. Cottini et al.   Cancer Discovery

Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality

(2014) Livnat Jerby-Arnon et al.   CELL

Larvicidal Activity of Essential Oil fromTetradenia ripariato Control ofAedes aegyptiLarvae in Function of Season Variation

(2014) Carla Maria Mariano Fernandez et al.   Journal of Essential Oil Bearing Plants

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Applying Synthetic Lethality for the Selective Targeting of Cancer

(2014) Donal P. McLornan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

(2013) Javier A. Menendez et al.   CELL CYCLE

Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond

(2013) Nicola J. Curtin et al.   MOLECULAR ASPECTS OF MEDICINE

Exploring the Yeast Acetylome Using Functional Genomics

(2012) Supipi Kaluarachchi Duffy et al.   CELL

Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs

(2012) S. Sharifpoor et al.   GENOME RESEARCH

Abbott boosts investment in NRF2 activators for reducing oxidative stress

(2012) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Xenohormesis mechanisms underlying chemopreventive effects of some dietary phytochemicals

(2011) Young-Joon Surh   Annals of the New York Academy of Sciences

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

(2011) Timothy A. Yap et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Identification of Chemosensitivity Nodes for Vinblastine through Small Interfering RNA High-Throughput Screens

(2011) C. A. Kitchens et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

(2011) Zhijian Li et al.   NATURE BIOTECHNOLOGY

Harnessing synthetic lethal interactions in anticancer drug discovery

(2011) Denise A. Chan et al.   NATURE REVIEWS DRUG DISCOVERY

Exogenous proline modifies differential expression of superoxide dismutase genes in UV-B-irradiated Salvia officinalis plants

(2011) N. L. Radyukina et al.   RUSSIAN JOURNAL OF PLANT PHYSIOLOGY

PTEN Loss Compromises Homologous Recombination Repair in Astrocytes: Implications for Glioblastoma Therapy with Temozolomide or Poly(ADP-Ribose) Polymerase Inhibitors

(2010) B. McEllin et al.   CANCER RESEARCH

Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant  -Catenin Activation in Colon Cancer

(2009) S. Naik et al.   CLINICAL CANCER RESEARCH

Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?

(2009) Bhushan Patwardhan et al.   DRUG DISCOVERY TODAY

Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds

(2009) Ajmi NoorShahida et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synthetic Lethality — A New Direction in Cancer-Drug Development

(2009) J. Dirk Iglehart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Xenohormesis: Sensing the Chemical Cues of Other Species

(2008) Konrad T. Howitz et al.   CELL

Pharmacogenetics in drug discovery and development: a translational perspective

(2008) Allen D. Roses   NATURE REVIEWS DRUG DISCOVERY

Transcriptional Modulation of Ethylene Response Factor Protein JERF3 in the Oxidative Stress Response Enhances Tolerance of Tobacco Seedlings to Salt, Drought, and Freezing

(2008) L. Wu et al.   PLANT PHYSIOLOGY

Western-medicine-validated anti-tumor agents and traditional Chinese medicine

(2007) Xue-Juan Li et al.   TRENDS IN MOLECULAR MEDICINE