Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors

Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2 Receptor Derived from the Natural Product Cannabidiol

(2021) Gemma Navarro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

(2020) Tian Hua et al.   CELL

Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

(2020) Changrui Xing et al.   CELL

Biological potential of varinic-, minor-, and acidic phytocannabinoids

(2020) Rafael Franco et al.   PHARMACOLOGICAL RESEARCH

Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors

(2020) Gemma Navarro et al.   PHARMACOLOGICAL RESEARCH

Δ 9 ‐Tetrahydrocannabinolic acid alleviates collagen‐induced arthritis: Role of PPARγ and CB 1 receptors

(2020) Belén Palomares et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor

(2020) Paula Morales et al.   CHEMISTRY-A EUROPEAN JOURNAL

Crystal Structure of the Human Cannabinoid Receptor CB2

(2019) Xiaoting Li et al.   CELL

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

(2019) Kaavya Krishna Kumar et al.   CELL

Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity

(2019) Belén Palomares et al.   BIOCHEMICAL PHARMACOLOGY

Molecular and functional interaction between GPR18 and cannabinoid CB 2 G-protein-coupled receptors. Relevance in neurodegenerative diseases

(2018) Irene Reyes-Resina et al.   BIOCHEMICAL PHARMACOLOGY

Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB 1 and CB 2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia

(2018) Gemma Navarro et al.   BRAIN BEHAVIOR AND IMMUNITY

Activity-Based Detection of Cannabinoids in Serum and Plasma Samples

(2018) Annelies Cannaert et al.   CLINICAL CHEMISTRY

Delta-9-tetrahydrocannabinolic acid A (THC-A) in urine of a 15-month-old child: A case report

(2018) Luca Morini et al.   FORENSIC SCIENCE INTERNATIONAL

Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA)

(2018) Cinzia Citti et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes

(2018) Gemma Navarro et al.   Frontiers in Pharmacology

Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1-CB2 heteroreceptor complexes

(2018) Gemma Navarro et al.   BIOCHEMICAL PHARMACOLOGY

Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1 G93A transgenic mice, an experimental model of amyotrophic lateral sclerosis

(2018) Carmen Rodríguez-Cueto et al.   BIOCHEMICAL PHARMACOLOGY

Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry

(2017) Philipp Fronik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures of agonist-bound human cannabinoid receptor CB1

(2017) Tian Hua et al.   NATURE

Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors

(2017) Eva Martínez-Pinilla et al.   Frontiers in Pharmacology

Design of Next-Generation G Protein–Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models

(2016) Sophie J. Bradley et al.   Annual Review of Pharmacology and Toxicology

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study

(2016) Khalid A. Jadoon et al.   DIABETES CARE

Δ9-Tetrahydrocannabinolic acid synthase: The application of a plant secondary metabolite enzyme in biocatalytic chemical synthesis

(2016) Kerstin Lange et al.   JOURNAL OF BIOTECHNOLOGY

Phytocannabinoids: a unified critical inventory

(2016) Lumír Ondřej Hanuš et al.   NATURAL PRODUCT REPORTS

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

(2016) Gemma Navarro et al.   Frontiers in Neuroscience

Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

(2016) Rafael Franco et al.   Frontiers in Pharmacology

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

(2015) R B Laprairie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism

(2014) Salvador Sierra et al.   Brain Structure & Function

The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

(2014) Dasiel Borroto-Escuela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Type 1 Cannabinoid Receptor Ligands Display Functional Selectivity in a Cell Culture Model of Striatal Medium Spiny Projection Neurons

(2014) Robert B. Laprairie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early phytocannabinoid chemistry to endocannabinoids and beyond

(2014) Raphael Mechoulam et al.   NATURE REVIEWS NEUROSCIENCE

Differences in receptor binding affinity of several phytocannabinoids do not explain their effects on neural cell cultures

(2014) Sarah Rosenthaler et al.   NEUROTOXICOLOGY AND TERATOLOGY

Development and validation of an LC-MS/MS method for quantification of Δ9-tetrahydrocannabinolic acid A (THCA-A), THC, CBN and CBD in hair

(2013) Nadine Roth et al.   JOURNAL OF MASS SPECTROMETRY

Mechanisms of cannabidiol neuroprotection in hypoxic–ischemic newborn pigs: Role of 5HT1A and CB2 receptors

(2013) M. Ruth Pazos et al.   NEUROPHARMACOLOGY

Molecular Alliance-From Orthosteric and Allosteric Ligands to Dualsteric/Bitopic Agonists at G Protein Coupled Receptors

(2012) Klaus Mohr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Endocannabinoid System and the Brain

(2012) Raphael Mechoulam et al.   Annual Review of Psychology

Cannabinoid Receptors CB1and CB2Form Functional Heteromers in Brain

(2012) Lucía Callén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency

(2012) Jiang Wu et al.   NEUROBIOLOGY OF AGING

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

(2011) Ethan B Russo   BRITISH JOURNAL OF PHARMACOLOGY

Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors

(2011) Sándor Bátkai et al.   BRITISH JOURNAL OF PHARMACOLOGY

The plant cannabinoid Δ9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice

(2010) Daniele Bolognini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hair analysis for Δ9-tetrahydrocannabinolic acid A—New insights into the mechanism of drug incorporation of cannabinoids into hair

(2010) Volker Auwärter et al.   FORENSIC SCIENCE INTERNATIONAL

Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas

(2010) Nephi Stella   GLIA

Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis

(2010) José L Lanciego et al.   JOURNAL OF PSYCHOPHARMACOLOGY

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice

(2009) Gernot Riedel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8

(2008) L. De Petrocellis et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo

(2007) R G Pertwee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

(2007) A Thomas et al.   BRITISH JOURNAL OF PHARMACOLOGY