An overview of the insulin signaling pathway in model organisms Drosophila melanogaster and Caenorhabditis elegans

Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans

(2021) Wen-Jun Li et al.   Nature Communications

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans

(2020) Bryan A Martinez et al.   eLife

Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity

(2020) Elizabeth B. Brown et al.   PLoS Genetics

Insulin signalling elicits hunger-induced feeding in Drosophila

(2019) Sreesha R. Sudhakar et al.   DEVELOPMENTAL BIOLOGY

Roles of the insulin signaling pathway in insect development and organ growth

(2018) Xianyu Lin et al.   PEPTIDES

Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

(2018) Stephanie Post et al.   Frontiers in Endocrinology

A functional study of all 40 C. elegans insulin-like peptides

(2018) Shanqing Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-Like Peptides Regulate Feeding Preference and Metabolism in Drosophila

(2018) Uliana V. Semaniuk et al.   Frontiers in Physiology

Drosophila insulin-like peptide dilp1 increases lifespan and glucagon-like Akh expression epistatic to dilp2

(2018) Stephanie Post et al.   AGING CELL

C. elegans PTEN and AMPK block neuroblast divisions by inhibiting a BMP-insulin-PP2A-MAPK pathway

(2018) Shanqing Zheng et al.   DEVELOPMENT

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum

(2016) Leena Haataja et al.   DIABETES

Context-dependent regulation of feeding behaviour by the insulin receptor, DAF-2, in Caenorhabditis elegans

(2016) James Dillon et al.   INVERTEBRATE NEUROSCIENCE

Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor

(2016) Masahiro Tomioka et al.   Nature Communications

Adult Drosophila melanogaster as a model for the study of glucose homeostasis

(2016) Aaron T. Haselton et al.   Aging-US

Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability

(2015) Julien Colombani et al.   CURRENT BIOLOGY

Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster

(2015) Matthias B. Van Hiel et al.   PEPTIDES

Regulation of Sleep by Insulin-like Peptide System in Drosophila melanogaster

(2015) Xiaona Cong et al.   SLEEP

Nutrition-dependent control of insect development by insulin-like peptides

(2015) Naoki Okamoto et al.   Current Opinion in Insect Science

Regulation of Sleep by Insulin-like Peptide System in Drosophila melanogaster

(2015) Xiaona Cong et al.   SLEEP

Insight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human Insulin

(2014) Lucie Kosinová et al.   BIOCHEMISTRY

A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication

(2014) W. L. Hung et al.   DEVELOPMENT

Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background

(2014) Tim Wolf et al.   EXPERIMENTAL GERONTOLOGY

Insulin Receptor Activation with Transmembrane Domain Ligands

(2014) Jongsoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans

(2014) H. Ohno et al.   SCIENCE

The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

(2013) Colin W. Ward et al.   BIOESSAYS

Complex expression dynamics and robustness in C. elegans insulin networks

(2013) A. D. Ritter et al.   GENOME RESEARCH

Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans

(2013) X. Karp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Rate Regulates L1 Longevity in C. elegans

(2012) Inhwan Lee et al.   PLoS One

A Steroid Receptor-MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad

(2012) Y. Shen et al.   SCIENCE

Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation

(2012) A. Garelli et al.   SCIENCE

Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing

(2012) J. Colombani et al.   SCIENCE

PTEN Negatively Regulates MAPK Signaling during Caenorhabditis elegans Vulval Development

(2012) Itay Nakdimon et al.   PLoS Genetics

Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in Drosophila and Mammals

(2012) Seung-Hyun Hong et al.   PLoS Genetics

Insulin Signaling Mediates Sexual Attractiveness in Drosophila

(2012) Tsung-Han Kuo et al.   PLoS Genetics

Hypertonic stress induces rapid and widespread protein damage in C. elegans

(2011) Kris Burkewitz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms

(2011) Louise Knudsen et al.   BIOCHEMICAL JOURNAL

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

Presynaptic Facilitation by Neuropeptide Signaling Mediates Odor-Driven Food Search

(2011) Cory M. Root et al.   CELL

Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis

(2011) Paola Cognigni et al.   Cell Metabolism

Neuronal plasticity regulated by the insulin-like signaling pathway underlies salt chemotaxis learning in Caenorhabditis elegans

(2011) Shigekazu Oda et al.   JOURNAL OF NEUROPHYSIOLOGY

Insulin Production and Signaling in Renal Tubules of Drosophila Is under Control of Tachykinin-Related Peptide and Regulates Stress Resistance

(2011) Jeannette A. E. Söderberg et al.   PLoS One

Energetics of Insect Diapause

(2010) Daniel A. Hahn et al.   Annual Review of Entomology

The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway

(2010) Min Fang et al.   CELL

TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance

(2010) Shijing Luo et al.   CELL

Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans

(2010) Gawain McColl et al.   Cell Metabolism

EAK-7 Controls Development and Life Span by Regulating Nuclear DAF-16/FoxO Activity

(2010) Hena Alam et al.   Cell Metabolism

Insulin signaling promotes germline proliferation in C. elegans

(2010) D. Michaelson et al.   DEVELOPMENT

The Steroid Hormone Ecdysone Controls Systemic Growth by Repressing dMyc Function in Drosophila Fat Cells

(2010) Rénald Delanoue et al.   DEVELOPMENTAL CELL

Insulin/Insulin-Like Growth Factor Signaling Controls Non-Dauer Developmental Speed in the Nematode Caenorhabditis elegans

(2010) A.-F. Ruaud et al.   GENETICS

Structural and Biological Properties of theDrosophilaInsulin-like Peptide 5 Show Evolutionary Conservation

(2010) Waseem Sajid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Neural Circuit that Underlies the Effects of Octopamine on Sleep:Wake Behavior

(2010) Amanda Crocker et al.   NEURON

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

(2010) S. Henis-Korenblit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarized Myosin Produces Unequal-Size Daughters During Asymmetric Cell Division

(2010) Guangshuo Ou et al.   SCIENCE

Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age

(2010) Amanda L. Kauffman et al.   PLOS BIOLOGY

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Molecular mechanisms of metabolic regulation by insulin inDrosophila

(2009) Aurelio A. Teleman   BIOCHEMICAL JOURNAL

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

(2009) Colin W. Ward et al.   BIOESSAYS

Remote Control of Insulin Secretion by Fat Cells in Drosophila

(2009) Charles Géminard et al.   Cell Metabolism

A Fat Body-Derived IGF-like Peptide Regulates Postfeeding Growth in Drosophila

(2009) Naoki Okamoto et al.   DEVELOPMENTAL CELL

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

The Insulin-like Growth Factor (IGF)-I E-Peptides Modulate Cell Entry of the Mature IGF-I Protein

(2009) Lindsay A. Pfeffer et al.   MOLECULAR BIOLOGY OF THE CELL

Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities

(2009) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Conservation of key members in the course of the evolution of the insulin signaling pathway

(2008) Janet Piñero González et al.   BIOSYSTEMS

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Regulatory peptides in fruit fly midgut

(2008) Jan A. Veenstra et al.   CELL AND TISSUE RESEARCH

foxo is required for resistance to amino acid starvation in Drosophila

(2008) Jamie M. Kramer et al.   GENOME

The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila

(2008) N. Vereshchagina et al.   JOURNAL OF CELL SCIENCE

Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling

(2008) Kyu-Sun Lee et al.   NATURE CELL BIOLOGY

PTEN: a new guardian of the genome

(2008) Y Yin et al.   ONCOGENE

Drosophila Egg-Laying Site Selection as a System to Study Simple Decision-Making Processes

(2008) C.-h. Yang et al.   SCIENCE

Postmitotic Specification of Drosophila Insulinergic Neurons from Pioneer Neurons

(2008) Irene Miguel-Aliaga et al.   PLOS BIOLOGY

Remarkable longevity and stress resistance of nematode PI3K-null mutants

(2007) Srinivas Ayyadevara et al.   AGING CELL

Insulin-Like Signaling, Nutrient Homeostasis, and Life Span

(2007) Akiko Taguchi et al.   Annual Review of Physiology