Neonatal multidrug-resistant gram-negative infection: epidemiology, mechanisms of resistance, and management

Infectious Diseases Society of America Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa)

(2021) Pranita D Tamma et al.   CLINICAL INFECTIOUS DISEASES

Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low- and middle-income countries

(2021) Kirsty Sands et al.   Nature Microbiology

Neonates with Maternal Colonization of Carbapenemase-Producing, Carbapenem-Resistant Enterobacteriaceae: A Mini-Review and a Suggested Guide for Preventing Neonatal Infection

(2021) Judy Seesahai et al.   Children-Basel

Maternal antibiotic exposure during pregnancy is a risk factor for community-acquired urinary tract infection caused by extended-spectrum beta-lactamase-producing bacteria in infants

(2021) Ji Hyun Kim et al.   PEDIATRIC NEPHROLOGY

Successful control of an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae ST307 outbreak in a neonatal intensive care unit

(2020) Eun-Hwa Baek et al.   BMC INFECTIOUS DISEASES

Epidemiology of β-Lactamase-Producing Pathogens

(2020) Karen Bush et al.   CLINICAL MICROBIOLOGY REVIEWS

Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study

(2020) David van Duin et al.   LANCET INFECTIOUS DISEASES

Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial

(2020) Irja Lutsar et al.   PLoS One

Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies

(2020) Barbara J. Stoll et al.   JAMA Pediatrics

High Carriage Rates of Multidrug-Resistant Gram-Negative Bacteria in Neonatal Intensive Care Units From Ghana

(2020) Appiah-Korang Labi et al.   Open Forum Infectious Diseases

Epidemiology and microbiology of late-onset sepsis among preterm infants in China, 2015–2018: A cohort study

(2020) Siyuan Jiang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Successful Treatment of Pandrug-resistant Klebsiella pneumoniae Infection With Ceftazidime-avibactam in a Preterm Infant

(2020) Yesim Coskun et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Reducing Vancomycin Use in a Level IV NICU

(2020) Rana F. Hamdy et al.   PEDIATRICS

Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial

(2020) Matteo Bassetti et al.   LANCET INFECTIOUS DISEASES

Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial

(2020) Richard G Wunderink et al.   LANCET INFECTIOUS DISEASES

Pediatric research priorities in healthcare-associated infections and antimicrobial stewardship

(2020) Susan E. Coffin et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Antibiotic Susceptibility of Escherichia coli Among Infants Admitted to Neonatal Intensive Care Units Across the US From 2009 to 2017

(2020) Dustin D. Flannery et al.   JAMA Pediatrics

Clinical characteristics, antimicrobial resistance and capsular types of community-acquired, healthcare-associated, and nosocomial Klebsiella pneumoniae bacteremia

(2019) Chih-Han Juan et al.   Antimicrobial Resistance and Infection Control

Defining the Role of Novel β-Lactam Agents That Target Carbapenem-Resistant Gram-Negative Organisms

(2019) Pranita D Tamma et al.   Journal of the Pediatric Infectious Diseases Society

Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli

(2019) George G. Zhanel et al.   DRUGS

Use of Ceftazidime-avibactam for the Treatment of Extensively drug-resistant or Pan drug-resistant Klebsiella pneumoniae in Neonates and Children

(2019) Elias Iosifidis et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Control of Acinetobacter baumannii outbreak in the neonatal intensive care unit in Latvia: whole-genome sequencing powered investigation and closure of the ward

(2019) A. Gramatniece et al.   Antimicrobial Resistance and Infection Control

Evaluation of empiric beta-lactam susceptibility prediction among Enterobacteriaceae by molecular beta-lactamase gene testing

(2019) Kyle Spafford et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Safety and Efficacy of Ceftazidime–Avibactam in the Treatment of Children ≥3 Months to

(2019) John S. Bradley et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Distribution of quinolone resistance gene (qnr) in ESBL-producing Escherichia coli and Klebsiella spp. in Lomé, Togo

(2019) Fortune Djimabi Salah et al.   Antimicrobial Resistance and Infection Control

A review of -multidrug-resistant Enterobacteriaceae in a neonatal unit in Johannesburg, South Africa

(2019) Daynia E. Ballot et al.   BMC Pediatrics

RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections

(2019) Johann Motsch et al.   CLINICAL INFECTIOUS DISEASES

Safety and Efficacy of Ceftazidime-Avibactam Plus Metronidazole in the Treatment of Children ≥3 Months to

(2019) John S. Bradley et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Molecular Epidemiology of Ceftriaxone-Nonsusceptible Enterobacterales Isolates in an Academic Medical Center in the United States

(2019) Pranita D Tamma et al.   Open Forum Infectious Diseases

Systematic review of carbapenem-resistant Enterobacteriaceae causing neonatal sepsis in China

(2019) Yijun Ding et al.   Annals of Clinical Microbiology and Antimicrobials

Predictors for gut colonization of carbapenem-resistant Enterobacteriaceae in neonates in a neonatal intensive care unit

(2018) Narendra Pal Singh et al.   AMERICAN JOURNAL OF INFECTION CONTROL

Why are preterm newborns at increased risk of infection?

(2018) Amélie Collins et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Role of association of OmpK35 and OmpK36 alteration and bla ESBL and/or bla AmpC genes in conferring carbapenem resistance among non-carbapenemase-producing Klebsiella pneumoniae

(2018) Zaineb Hamzaoui et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Global survey of Klebsiella pneumoniae major porins from ertapenem non-susceptible isolates lacking carbapenemases

(2018) Mark G. Wise et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Multidrug efflux pumps: structure, function and regulation

(2018) Dijun Du et al.   NATURE REVIEWS MICROBIOLOGY

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance

(2018) Patrick N. A. Harris et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Management of Neonates Born at ≤34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis

(2018) Karen M. Puopolo et al.   PEDIATRICS

Pharmacokinetics of the Meropenem Component of Meropenem‐Vaborbactam in the Treatment of KPC ‐Producing Klebsiella pneumoniae Bloodstream Infection in a Pediatric Patient

(2018) Alexandra M. Hanretty et al.   PHARMACOTHERAPY

Impact of antimicrobial stewardship and rapid microarray testing on patients with Gram-negative bacteremia

(2017) K. R. Rivard et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Dosing antibiotics in neonates: review of the pharmacokinetic data

(2017) Nazario D Rivera-Chaparro et al.   Future Microbiology

Comparison of 11 Phenotypic Assays for Accurate Detection of Carbapenemase-Producing Enterobacteriaceae

(2017) Pranita D. Tamma et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Multi-drug-resistant Enterobacteriaceae in a Portuguese neonatal intensive care unit

(2017) H. Pragosa et al.   JOURNAL OF HOSPITAL INFECTION

Risk factors and clinical outcomes for carbapenem-resistant Gram-negative late-onset sepsis in a neonatal intensive care unit

(2017) I. Nour et al.   JOURNAL OF HOSPITAL INFECTION

The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace

(2017) Latania K. Logan et al.   JOURNAL OF INFECTIOUS DISEASES

The ecology of extended-spectrum β-lactamases (ESBLs) in the developed world

(2017) Yohei Doi et al.   JOURNAL OF TRAVEL MEDICINE

Ending the Culture of Culture-Negative Sepsis in the Neonatal ICU

(2017) Joseph B. Cantey et al.   PEDIATRICS

Plazomicin activity against 346 Extended-Spectrum-β-lactamase/AmpC-producing Escherichia coli urinary isolates, related to aminoglycoside-modifying enzymes characterized.

(2016) Maria del Carmen López-Diaz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Neonatal infections with multidrug-resistant ESBL-producing E. cloacae and K. pneumoniae in Neonatal Units of two different Hospitals in Antananarivo, Madagascar

(2016) T. Naas et al.   BMC INFECTIOUS DISEASES

Carbapenem-resistant Klebsiella pneumoniae colonization in pediatric and neonatal intensive care units: risk factors for progression to infection

(2016) Hacer Akturk et al.   Brazilian Journal of Infectious Diseases

Genome-based phylogeny and taxonomy of the ‘Enterobacteriales’: proposal for Enterobacterales ord. nov. divided into the families Enterobacteriaceae, Erwiniaceae fam. nov., Pectobacteriaceae fam. nov., Yersiniaceae fam. nov., Hafniaceae fam. nov., Morganellaceae fam. nov., and Budviciaceae fam. nov.

(2016)   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Clinical Impact of Laboratory Implementation of Verigene BC-GN Microarray-Based Assay for Detection of Gram-Negative Bacteria in Positive Blood Cultures

(2016) Tamar Walker et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Healthcare-associated infections due to carbapenemase-producing Enterobacteriaceae: Bacteriological profile and risk factors

(2016) M. Chabah et al.   MEDECINE ET MALADIES INFECTIEUSES

The Increasing Challenge of Multidrug-Resistant Gram-Negative Bacilli

(2016) Mario Giuffrè et al.   MEDICINE

High Prevalence of Antimicrobial-resistant Gram-negative Colonization in Hospitalized Cambodian Infants

(2016) Paul Turner et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Epidemiology of Invasive Early-Onset Neonatal Sepsis, 2005 to 2014

(2016) S. J. Schrag et al.   PEDIATRICS

Successful elimination of extended-spectrum beta-lactamase (ESBL)-producing nosocomial bacteria at a neonatal intensive care unit

(2016) Borbála Szél et al.   World Journal of Pediatrics

Altered Outer Membrane Transcriptome Balance with AmpC Overexpression in Carbapenem-Resistant Enterobacter cloacae

(2016) Piotr Majewski et al.   Frontiers in Microbiology

Association Between Antibiotic Use and Neonatal Mortality and Morbidities in Very Low-Birth-Weight Infants Without Culture-Proven Sepsis or Necrotizing Enterocolitis

(2016) Joseph Y. Ting et al.   JAMA Pediatrics

Characterisation and antimicrobial resistance of sepsis pathogens in neonates born in tertiary care centres in Delhi, India: a cohort study

(2016)   Lancet Global Health

Gram-negative Bacilli in Infants Hospitalized in The Neonatal Intensive Care Unit

(2016) Sameer J. Patel et al.   Journal of the Pediatric Infectious Diseases Society

Clinical and Molecular Characteristics of Neonatal Extended-Spectrum β-Lactamase-Producing Gram-Negative Bacteremia: A 12-Year Case-Control-Control Study of a Referral Center in Taiwan

(2016) Ming-Horng Tsai et al.   PLoS One

Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City

(2015) Amabel Lapuebla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Outbreaks of extended spectrum beta-lactamase-producing Enterobacteriaceae in neonatal intensive care units: a systematic review

(2015) Patrick JM Stapleton et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Epidemiology of Carbapenem-Resistant Enterobacteriaceae in 7 US Communities, 2012-2013

(2015) Alice Y. Guh et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Infections Caused by Resistant Gram-Negative Bacteria: Epidemiology and Management

(2015) Keith S. Kaye et al.   PHARMACOTHERAPY

Prolonged Early Antibiotic Use and Bronchopulmonary Dysplasia in Very Low Birth Weight Infants

(2014) Alexandra Novitsky et al.   AMERICAN JOURNAL OF PERINATOLOGY

Genome Sequencing of an Extended Series of NDM-Producing Klebsiella pneumoniae Isolates from Neonatal Infections in a Nepali Hospital Characterizes the Extent of Community- versus Hospital-Associated Transmission in an Endemic Setting

(2014) N. Stoesser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Treatment of Multidrug-Resistant Gram-Negative Infections in Children

(2014) A. J. Hsu et al.   CLINICAL INFECTIOUS DISEASES

Addressing the Emergence and Impact of Multidrug-Resistant Gram-Negative Organisms: A Critical Focus for the Next Decade

(2014) Ebbing Lautenbach et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Variation in Definitions and Isolation Procedures for Multidrug-Resistant Gram-Negative Bacteria: A Survey of the Society for Healthcare Epidemiology of America Research Network

(2014) Marci Drees et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

The mother as most important risk factor for colonization of very low birth weight (VLBW) infants with extended-spectrum  -lactamase-producing Enterobacteriaceae (ESBL-E)

(2014) L. A. Denkel et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

Epidemiology and Clinical Outcomes of Multidrug-resistant, Gram-negative Bloodstream Infections in a European Tertiary Pediatric Hospital During a 12-month Period

(2014) Laura Folgori et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Risk Factors and Outcomes for Multidrug-Resistant Gram-Negative Bacteremia in the NICU

(2014) M.-H. Tsai et al.   PEDIATRICS

Extended-Spectrum β-Lactamase–Producing and Third-Generation Cephalosporin-Resistant Enterobacteriaceae in Children: Trends in the United States, 1999–2011

(2014) Latania K. Logan et al.   Journal of the Pediatric Infectious Diseases Society

Outbreak of NDM-1-Producing Klebsiella pneumoniae in a Neonatal Unit in Colombia

(2013) Javier Antonio Escobar Pérez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prevalence of β-Lactamase-Encoding Genes among Enterobacteriaceae Bacteremia Isolates Collected in 26 U.S. Hospitals: Report from the SENTRY Antimicrobial Surveillance Program (2010)

(2013) Mariana Castanheira et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prompt Control of an Outbreak Caused by Extended-Spectrum β-Lactamase–Producing Klebsiella pneumoniae in a Neonatal Intensive Care Unit

(2013) Joseph B. Cantey et al.   JOURNAL OF PEDIATRICS

Utility of Surveillance Cultures for Antimicrobial Resistant Organisms in Infants Transferred to the Neonatal Intensive Care Unit

(2013) Theodore Macnow et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Enterobacteriaceae Infections of Very Low Birth Weight Infants in Polish Neonatal Intensive Care Units

(2013) Jadwiga Wójkowska-Mach et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

High Proportion of Intestinal Colonization with Successful Epidemic Clones of ESBL-Producing Enterobacteriaceae in a Neonatal Intensive Care Unit in Ecuador

(2013) Viveka Nordberg et al.   PLoS One

Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study

(2013) Nandini Vijayakanthi et al.   Biomed Research International

First outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a Norwegian neonatal intensive care unit; associated with contaminated breast milk and resolved by strict cohorting

(2012) Siren Rettedal et al.   APMIS

Continuous Surveillance to Reduce Extended-Spectrum �-Lactamase Klebsiella pneumoniae Colonization in the Neonatal Intensive Care Unit

(2012) Shmuel Benenson et al.   Neonatology

Long-Term Follow-Up after Neonatal Colonization with Extended Spectrum Beta-Lactamase Gram-Negative Bacteria

(2012) K Kock et al.   PEDIATRIC RESEARCH

Risk factors for acquisition of CTX-M-15 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae during an outbreak in a neonatal intensive care unit in Norway

(2012) Siren Rettedal et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

High load of multi-drug resistant nosocomial neonatal pathogens carried by cockroaches in a neonatal intensive care unit at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia

(2012) Birkneh Tilahun et al.   Antimicrobial Resistance and Infection Control

Klebsiella pneumoniaeOuter Membrane Porins OmpK35 and OmpK36 Play Roles in both Antimicrobial Resistance and Virulence

(2011) Yu-Kuo Tsai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

National surveillance study of extended spectrum   lactamase (ESBL) producing organism infection in neonatal units of england and wales

(2011) S. Mitra et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Multi-drug resistant gram negative bacilli causing early neonatal sepsis in India

(2011) Rajlakshmi Viswanathan et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Coagulase-Negative Staphylococcal Infections in the Neonatal Intensive Care Unit

(2011) Naomi Jean-Baptiste et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Prolonged Initial Empirical Antibiotic Treatment is Associated with Adverse Outcomes in Premature Infants

(2011) Venkata S. Kuppala et al.   JOURNAL OF PEDIATRICS

Emergence of Klebsiella pneumoniae Carbapenemase-Producing Bacteria

(2011) Ryan S. Arnold et al.   SOUTHERN MEDICAL JOURNAL

Neonatal infections in England: the NeonIN surveillance network

(2010) S. Vergnano et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Empirical treatment of neonatal sepsis: are the current guidelines adequate?

(2010) B. Muller-Pebody et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Antibiotic Resistance in Neonatal Intensive Care Unit Pathogens: Mechanisms, Clinical Impact, and Prevention Including Antibiotic Stewardship

(2010) Sameer J. Patel et al.   CLINICS IN PERINATOLOGY

Restriction of cephalosporins and control of extended spectrum β-lactamase producing gram negative bacteria in a neonatal intensive care unit

(2010) Srinivas Murki et al.   INDIAN PEDIATRICS

Acquisition of extended-spectrum  -lactamase producing Escherichia coli strains in male and female infants admitted to a neonatal intensive care unit: molecular epidemiology and analysis of risk factors

(2010) S. Shakil et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Concordance of Gastrointestinal Tract Colonization and Subsequent Bloodstream Infections With Gram-negative Bacilli in Very Low Birth Weight Infants in the Neonatal Intensive Care Unit

(2010) Ann Smith et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Effectiveness of a Guideline to Reduce Vancomycin Use in the Neonatal Intensive Care Unit

(2010) Chia-Hua Chiu et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Isolates in the United States: Clonal Expansion of Multilocus Sequence Type 258

(2009) B. Kitchel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Updated Functional Classification of  -Lactamases

(2009) K. Bush et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nosocomial multidrug-resistant Acinetobacter baumannii in the neonatal intensive care unit in Gaza City, Palestine

(2009) Abdel Moati Kh. Al Jarousha et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK

(2009) M. Doumith et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Risk factors for colonisation of newborn infants during an outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in an intermediate-risk neonatal unit

(2009) V.C. Cassettari et al.   JOURNAL OF HOSPITAL INFECTION

Extended-spectrum β-lactamase producing Klebsiella pneumoniae in neonatal intensive care unit

(2008) H Abdel-Hady et al.   Journal of Perinatology

Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated With Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants

(2008) C. M. Cotten et al.   PEDIATRICS