Review
Pharmacology & Pharmacy
Min Hong, Jiabing Rong, Xinran Tao, Yinchuan Xu
Summary: Ferroptosis is a type of programmed cell death characterized by iron-dependent lipid peroxidation, which differs from traditional cell death types in morphology, biochemistry, and genetics. It has been found to play a major role in cardiovascular diseases, and this review discusses its mechanisms and effects on the occurrence and development of such diseases, aiming to provide a new target for their prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Si Chen, Jun-yao Zhu, Xin Zang, Yong-zhen Zhai
Summary: Ferroptosis, mediated by iron-dependent lipid peroxide, participates in various diseases with distinct roles. Regulating ferroptosis may have dual effects in counteracting the progression of liver diseases and the development of drug resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hela Mkaouar, Vincent Mariaule, Soufien Rhimi, Juan Hernandez, Aicha Kriaa, Amin Jablaoui, Nizar Akermi, Emmanuelle Maguin, Adam Lesner, Brice Korkmaz, Moez Rhimi
Summary: Inflammatory bowel diseases are incurable disorders with increasing prevalence and global socioeconomic impact. Gut microbiota dysbiosis and increased activity of serine proteases may play roles in the onset and maintenance of the disease, with potential therapeutic relevance of gut microbiota serpins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yajie Wang, Bufu Tang, Jinyu Zhu, Junchao Yu, Junguo Hui, Shuiwei Xia, Jiansong Ji
Summary: Ferroptosis is a novel type of cell death associated with cancer and neurodegenerative diseases. It can be selectively induced for cancer treatment or inhibited for neurodegenerative diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Immunology
Junyu Fan, Ting Jiang, Dongyi He
Summary: This review summarizes recent advancements in the interaction between ferroptosis and the immune system, with a focus on autoimmune diseases. It provides a comprehensive understanding of the critical regulators of ferroptosis and highlights the molecular crosstalk between ferroptosis and different immune cells. Future research is expected to uncover the mechanisms governing ferroptosis and explore its therapeutic potential in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Chun Ge, Sujie Zhang, Huiwen Mu, Shaojun Zheng, Zhaoyi Tan, Xintong Huang, Chen Xu, Jianjun Zou, Yubing Zhu, Dong Feng, Jiye Aa
Summary: Ferroptosis is a newly discovered form of regulatory cell death that is distinct from other types of cell death. It is characterized by iron-dependent lipid peroxidation and oxidative perturbation, and can be inhibited by iron chelators and lipophilic antioxidants. This process is implicated in various biological contexts, including iron homeostasis, lipid metabolism, and glutathione metabolism. Ferroptosis is closely related to physiological and pathological processes such as tumor progression, (neuro)degenerative diseases, and hepatic and renal failure. There is a need for the discovery of novel compounds that can modulate ferroptosis, despite the existence of some experimental reagents and approved clinical drugs with anti- or pro-ferroptotic properties. This review discusses the molecular mechanisms of ferroptotic death and its roles in different pathophysiological contexts, as well as chemical compounds and natural products that can induce or inhibit ferroptosis for the prevention and treatment of various diseases. It emphasizes the promising prospects of natural products in ferroptosis-associated therapy due to their multiple components, multiple biotargets, and slight side effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Geriatrics & Gerontology
Yiyan Sun, Xiaohuan Xia, Diksha Basnet, Jialin C. Zheng, Jian Huang, Jianhui Liu
Summary: Neurodegenerative diseases are characterized by the degeneration of neuronal cells and synaptic loss, with ferroptosis playing an important role in the pathogenesis.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Oncology
Jiaqi Shi, Ning Yang, Mingzhi Han, Chen Qiu
Summary: This review provides an overview of the characteristics, key regulators, and pathways of ferroptosis in glioma treatment. The crosstalk between ferroptosis and other programmed cell death in glioma is also discussed, along with the potential application and prospects of ferroptosis as a target for glioma treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Gastroenterology & Hepatology
Natalia Szostak, Marek Figlerowicz, Anna Philips
Summary: In recent years, the role of gut microbiota in human health and disease has gained increasing attention. However, most studies on the gut microbiome primarily focus on bacteria and neglect the fungi that exist in the human intestines. This review highlights the importance of the gut mycobiome in liver homeostasis and its perturbations, emphasizing the compositional changes of fungi in liver diseases and providing new insights for liver research and potential therapeutic targets.
Review
Cell Biology
Shu Xu, Yao He, Lihui Lin, Peng Chen, Minhu Chen, Shenghong Zhang
Summary: Ferroptosis is a newly recognized type of regulated cell death characterized by iron-dependent accumulation of lipid peroxidation, which is significantly distinct from other forms of cell death at morphological, biochemical, and genetic levels. Recent studies have linked ferroptosis to various diseases, including neurological disorders, kidney injury, liver diseases, and cancer, as well as dysfunction of the intestinal epithelium, which contributes to intestinal diseases.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Hui Zhao, Cheng Tang, Miao Wang, Hongfang Zhao, Yan Zhu
Summary: This review discusses the role and mechanism of ferroptosis in rheumatoid arthritis (RA), and explores its potential and challenges as a new therapeutic strategy, providing new targets for the prevention and treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Kai Wang, Xin-Zhe Chen, Yun-Hong Wang, Xue-Li Cheng, Yan Zhao, Lu-Yu Zhou, Kun Wang
Summary: The development of cardiovascular diseases is associated with ferroptosis, which may be a potential therapeutic drug target for CVDs.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Yijun Zhang, Yun Lu, Liping Jin
Summary: This review summarizes the molecular mechanisms and regulatory signals of placental iron trafficking, as well as the role of iron metabolism and ferroptosis in pregnancy-related diseases such as preeclampsia and gestational diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hongshuo Zhang, Juan Zhang, Haojie Dong, Ying Kong, Youfei Guan
Summary: In 2012, a new form of cell death called ferroptosis was proposed, which is non-apoptotic and iron-dependent, caused by lipid peroxidation. In the past decade, researchers have gained a comprehensive understanding of ferroptosis and its association with various aspects such as tumor microenvironment, cancer, immunity, aging, and tissue damage. O-GlcNAc modification of proteins has been found to play a role in cell survival in response to stress stimuli, but its function and mechanism in regulating ferroptosis are still not well understood. This review examines recent literature and discusses the potential mechanisms of O-GlcNAcylation in regulating ferroptosis, including antioxidant defense system-controlled reactive oxygen species biology, iron metabolism, and membrane lipid peroxidation metabolism as well as changes in subcellular organelles involved in O-GlcNAcylation that may trigger and amplify ferroptosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lixing Cao, Shuang Zhao, Kai Han, Lihong Fan, Chong Zhao, Shutao Yin, Hongbo Hu
Summary: Ferroptosis is a form of programmed cell death that is dependent on iron and caused by excessive oxidation of phospholipids on cellular membranes. It has been implicated in various diseases including cardiovascular diseases, neurological diseases, liver diseases, kidney injury, lung injury, diabetes, and cancer. Targeting ferroptosis through dietary intervention is considered to be an effective strategy for preventing and treating ferroptosis-associated diseases. This review summarizes the functional role of ferroptosis in the pathogenesis of these diseases and discusses the evidence of managing ferroptosis-related diseases with dietary modulators of ferroptosis. The review also addresses the issues that need to be addressed to promote the practical application of dietary approaches targeting ferroptosis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)