Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process

Manufacturing Process Development for Belzutifan, Part 3: Completing a Streamlined Through-Process with a Safe and Scalable Oxidation

(2021) Zhiwei Chen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation Control

(2021) Nastaran Salehi Marzijarani et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination

(2021) Cecilia Bottecchia et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Manufacturing Process Development for Belzutifan, Part 1: A Concise Synthesis of the Indanone Starting Material

(2021) Feng Peng et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Manufacturing Process Development for Belzutifan, Part 6: Ensuring Scalability for a Deoxyfluorination Reaction

(2021) Michael Pirnot et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The Electrophilic Fluorination of Enol Esters Using SelectFluor: A Polar Two‐Electron Process

(2019) Susanna H. Wood et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hypoxia signaling in human diseases and therapeutic targets

(2019) Jae W. Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

(2019) Rui Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of hypoxia-inducible factor-2 alpha in angiogenesis

(2018) Christina Befani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Practical Asymmetric Fluorination Approach to the Scalable Synthesis of New Fluoroaminothiazine BACE Inhibitors

(2018) Pablo Garcia-Losada et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A quantitative reactivity scale for electrophilic fluorinating reagents

(2018) Neshat Rozatian et al.   Chemical Science

Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor

(2015) Neil R. Curtis et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A One-Pot Diazotation–Fluorodediazoniation Reaction and Fluorine Gas for the Production of Fluoronaphthyridines

(2014) Stefan Abele et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT