Deubiquitylase USP12 induces pro-survival autophagy and bortezomib resistance in multiple myeloma by stabilizing HMGB1

NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma

(2020) Jiliang Xia et al.   Molecular Oncology

USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity

(2020) Jin Liu et al.   PLoS Pathogens

Multiple Myeloma: Available Therapies and Causes of Drug Resistance

(2020) Vanessa Pinto et al.   Cancers

High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies

(2020) Shunling Yuan et al.   Journal of Hematology & Oncology

PFN1 Induces drug resistance through Beclin1 Complex mediated autophagy in multiple myeloma

(2018) Yichen Lu et al.   CANCER SCIENCE

Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12

(2018) Urszula L. McClurg et al.   ONCOGENE

HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair

(2018) Xing Guo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades

(2017) Fahd Boutouja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LncRNA MALAT-1 Elevates HMGB1 to Promote Autophagy Resulting in Inhibition of Tumor Cell Apoptosis in Multiple Myeloma

(2017) Da Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting autophagy in multiple myeloma

(2017) Zhuang Yun et al.   LEUKEMIA RESEARCH

ClC5 Decreases the Sensitivity of Multiple Myeloma Cells to Bortezomib via Promoting Pro-Survival Autophagy

(2017) Huimin Zhang et al.   ONCOLOGY RESEARCH

Multiple myeloma

(2017) Shaji K. Kumar et al.   Nature Reviews Disease Primers

Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo

(2016) Vidal Jarauta et al.   CANCER LETTERS

Immune Therapies in Multiple Myeloma

(2016) Shaji K. Kumar et al.   CLINICAL CANCER RESEARCH

Autophagy in Plasma Cell Ontogeny and Malignancy

(2016) Enrico Milan et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling

(2016) Akhee S. Jahan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma

(2016) Mridul Roy et al.   Theranostics

Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses

(2015) J Arnold et al.   CELL DEATH AND DIFFERENTIATION

Anti-β2-microglobulin monoclonal antibodies overcome bortezomib resistance in multiple myeloma by inhibiting autophagy

(2015) Mingjun Zhang et al.   Oncotarget

UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression

(2015) Sajjad Hussain et al.   Oncotarget

The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila

(2015) Anne-Claire Jacomin et al.   PLoS One

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

(2013) Z. Tian et al.   BLOOD

Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients

(2013) S K Kumar et al.   LEUKEMIA

Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells

(2013) Xudong Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Recombinant thrombomodulin improved Stevens-Johnson syndrome with high serum high-mobility group-B1 DNA-binding protein induced by lenalidomide administered to treat multiple myeloma

(2013) Yasuyuki Inoue et al.   THROMBOSIS RESEARCH

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

(2012) Dharminder Chauhan et al.   CANCER CELL

The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation

(2012) Julien Moretti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and disease: always two sides to a problem

(2011) Sunandini Sridhar et al.   JOURNAL OF PATHOLOGY

Regulation of Histone H2A and H2B Deubiquitination andXenopusDevelopment by USP12 and USP46

(2010) Heui-Yun Joo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

(2010) Shinichiro Nakada et al.   NATURE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY