Are ion channels potential therapeutic targets for Parkinson’s disease?
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Are ion channels potential therapeutic targets for Parkinson’s disease?
Authors
Keywords
Calcium ions, Potassium ions, Excitotoxicity, Voltage-gated calcium channels
Journal
NEUROTOXICOLOGY
Volume 87, Issue -, Pages 243-257
Publisher
Elsevier BV
Online
2021-10-25
DOI
10.1016/j.neuro.2021.10.008
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology
- (2021) Jinhong Wie et al. NATURE
- Long-Term Efficacy and Safety of Zonisamide for Treatment of Parkinsonism in Patients With Dementia With Lewy Bodies: An Open-Label Extension of a Phase three Randomized Controlled Trial
- (2021) Toshinari Odawara et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels
- (2020) Srikanth Dudem et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms
- (2020) Ze-Jun Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease
- (2020) Hyemin Gu et al. Toxins
- Potassium channels and their emerging role in parkinson's disease
- (2020) Linlin Zhang et al. BRAIN RESEARCH BULLETIN
- Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD
- (2020) Deirdre B. Hoban et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of KATP channel blockade and activation in the protection against neurodegeneration in the rotenone model of Parkinson's disease
- (2020) Noha F. Abdelkader et al. LIFE SCIENCES
- The Rostock International Parkinson's Disease ( ROPAD ) Study: Protocol and Initial Findings
- (2020) Volha Skrahina et al. MOVEMENT DISORDERS
- Zonisamide for the Treatment of Parkinson Disease: A Current Update
- (2020) Chengqian Li et al. Frontiers in Neuroscience
- α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide
- (2020) E. Hill et al. eNeuro
- The Potential of L-Type Calcium Channels as a Drug Target for Neuroprotective Therapy in Parkinson's Disease
- (2019) Birgit Liss et al. Annual Review of Pharmacology and Toxicology
- L-DOPA-quinone Mediated Recovery from GIRK Channel Firing Inhibition in Dopaminergic Neurons
- (2019) Bruno M. Bizzarri et al. ACS Medicinal Chemistry Letters
- TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia
- (2019) Thomas F. Tropea et al. ANNALS OF NEUROLOGY
- Pathophysiological clues to therapeutic applications of glutamate mGlu5 receptor antagonists in levodopa-induced dyskinesia
- (2019) Shayan Pourmirbabaei et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Recent expansions of novel strategies towards the drug targeting into the brain
- (2019) Amit Alexander et al. International Journal of Nanomedicine
- Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease
- (2019) Jonathan W. McKinley et al. NEURON
- Endogenous HCN Channels Modulate the Firing Activity of Globus Pallidus Neurons in Parkinsonian Animals
- (2019) Xiao-Meng Hao et al. Frontiers in Aging Neuroscience
- Identification of potential diagnostic biomarkers for Parkinson's disease
- (2019) Fenghua Jiang et al. FEBS Open Bio
- Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: An Emerging Role in Neurodegenerative Diseases
- (2019) Xiaoli Chang et al. Frontiers in Molecular Neuroscience
- Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
- (2019) Julia Benkert et al. Nature Communications
- NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons
- (2019) Carsten Simons et al. Frontiers in Molecular Neuroscience
- The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson’s disease
- (2019) Jia Lu et al. Journal of Neuroinflammation
- Effect of zonisamide on parkinsonism in patients with dementia with Lewy bodies: A phase 3 randomized clinical trial
- (2019) Miho Murata et al. PARKINSONISM & RELATED DISORDERS
- The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Na v 1.6
- (2018) Muhammad M. Hossain et al. EXPERIMENTAL NEUROLOGY
- Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress
- (2018) Jaime N. Guzman et al. JOURNAL OF CLINICAL INVESTIGATION
- Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration
- (2018) Ru-Yi Chao et al. JOURNAL OF NEUROCHEMISTRY
- Kir6.2 Deficiency Promotes Mesencephalic Neural Precursor Cell Differentiation via Regulating miR-133b/GDNF in a Parkinson’s Disease Mouse Model
- (2018) Yan Zhou et al. MOLECULAR NEUROBIOLOGY
- Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells
- (2018) Federica Frigerio et al. MOLECULAR NEUROBIOLOGY
- Disease Modification in Parkinson's Disease: Current Approaches, Challenges, and Future Considerations
- (2018) Anthony E. Lang et al. MOVEMENT DISORDERS
- Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson's disease and levodopa-induced dyskinesia
- (2018) Melissa Crabbé et al. NEUROBIOLOGY OF AGING
- A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease
- (2018) Monty A. Silverdale et al. PARKINSONISM & RELATED DISORDERS
- The Parkinson Pandemic—A Call to Action
- (2018) E. Ray Dorsey et al. JAMA Neurology
- The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo
- (2018) Jacopo Di Lucente et al. GLIA
- NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology
- (2018) Manuela Mellone et al. NEUROBIOLOGY OF DISEASE
- Safinamide in the management of patients with Parkinson’s disease not stabilized on levodopa: a review of the current clinical evidence
- (2018) Sagari Bette et al. Therapeutics and Clinical Risk Management
- The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
- (2018) Geraldine Hipp et al. Frontiers in Aging Neuroscience
- T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease
- (2018) Yoshikuni Tabata et al. Stem Cell Reports
- Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats
- (2017) Ezia Guatteo et al. EXPERIMENTAL NEUROLOGY
- Lower Affinity of Isradipine for L-Type Ca 2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease
- (2017) Nadine J. Ortner et al. JOURNAL OF NEUROSCIENCE
- Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels
- (2017) Rebekah C. Evans et al. JOURNAL OF NEUROSCIENCE
- A Model of the Block of Voltage-Gated Potassium Kv4.2 Ionic Currents by 4-Aminopyridine
- (2017) Steven J. Kehl JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Dalfampridine in Parkinson's disease related gait dysfunction: A randomized double blind trial
- (2017) Corneliu C. Luca et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Trial of dextromethorphan/quinidine to treat levodopa-induced dyskinesia in Parkinson's disease
- (2017) Susan H. Fox et al. MOVEMENT DISORDERS
- Zonisamide inhibits monoamine oxidase and enhances motor performance and social activity
- (2017) Maiko T. Uemura et al. NEUROSCIENCE RESEARCH
- Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
- (2017) Poonam Thakur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Hyperpolarization-Activated Current Determines Synaptic Excitability, Calcium Activity and Specific Viability of Substantia Nigra Dopaminergic Neurons
- (2017) Carmen Carbone et al. Frontiers in Cellular Neuroscience
- Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model
- (2017) Shuiqin Niu et al. Theranostics
- A novel design of a Phase III trial of isradipine in early Parkinson disease (STEADY-PD III)
- (2017) Kevin M. Biglan et al. Annals of Clinical and Translational Neurology
- New insights into SMA pathogenesis: immune dysfunction and neuroinflammation
- (2017) Marc-Olivier Deguise et al. Annals of Clinical and Translational Neurology
- Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets
- (2017) Anne Michel et al. PLoS One
- Small-conductance calcium-activated potassium type 2 channels (SK2, KCa2.2) in human brain
- (2016) Michael Willis et al. Brain Structure & Function
- HCN Channels Modulators: The Need for Selectivity
- (2016) Maria Novella Romanelli et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- KCa3.1-a microglial target ready for drug repurposing?
- (2016) Elena Dale et al. GLIA
- Decrease of a Current Mediated by K v 1.3 Channels Causes Striatal Cholinergic Interneuron Hyperexcitability in Experimental Parkinsonism
- (2016) Cecilia Tubert et al. Cell Reports
- Differential contribution of Ih to the integration of excitatory synaptic inputs in substantia nigra pars compacta and ventral tegmental area dopaminergic neurons
- (2015) Alessio Masi et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease
- (2015) Dominik Haddad et al. FEBS LETTERS
- Zonisamide reduces nigrostriatal dopaminergic neurodegeneration in a mouse genetic model of Parkinson's disease
- (2015) Hiromi Sano et al. JOURNAL OF NEUROCHEMISTRY
- Tonic Firing Rate Controls Dendritic Ca2+ Signaling and Synaptic Gain in Substantia Nigra Dopamine Neurons
- (2015) T. A. Hage et al. JOURNAL OF NEUROSCIENCE
- Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains
- (2015) Katherine R. Brimblecombe et al. JOURNAL OF PHYSIOLOGY-LONDON
- The NR2B antagonist, ifenprodil, corrects the l-DOPA-induced deficit of bilateral movement and reduces c-Fos expression in the subthalamic nucleus of hemiparkinsonian rats
- (2015) Masakazu Igarashi et al. NEUROSCIENCE RESEARCH
- NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients
- (2015) Manuela Mellone et al. Frontiers in Cellular Neuroscience
- Dysfunctional HCN ion channels in neurological diseases
- (2015) Jacopo C. DiFrancesco et al. Frontiers in Cellular Neuroscience
- Selective increase ofin vivofiring frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain
- (2014) Mahalakshmi Subramaniam et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia
- (2014) Marlen Michaelis et al. GLIA
- SK channel blockade reverses cognitive and motor deficits induced by nigrostriatal dopamine lesions in rats
- (2014) Lin Chen et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Mutant α-Synuclein Enhances Firing Frequencies in Dopamine Substantia Nigra Neurons by Oxidative Impairment of A-Type Potassium Channels
- (2014) Mahalakshmi Subramaniam et al. JOURNAL OF NEUROSCIENCE
- Role of Small Conductance Ca2+-Activated K+ Channels in Controlling CA1 Pyramidal Cell Excitability
- (2014) S. Chen et al. JOURNAL OF NEUROSCIENCE
- Firing Pattern Modulation Through SK Channel Current Increase Underlies Neuronal Survival in an Organotypic Slice Model of Parkinson’s Disease
- (2014) Yuan Wang et al. MOLECULAR NEUROBIOLOGY
- Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons
- (2014) Andrew G. Yee et al. NEUROTOXICOLOGY
- Neuronal expression of the intermediate conductance calcium-activated potassium channel KCa3.1 in the mammalian central nervous system
- (2014) Ray W. Turner et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons
- (2014) A M Dolga et al. Cell Death & Disease
- Calbindin content and differential vulnerability of midbrain efferent dopaminergic neurons in macaques
- (2014) Iria G. Dopeso-Reyes et al. Frontiers in Neuroanatomy
- Parkinson’s disease is associated with altered expression of CaV1 channels and calcium-binding proteins
- (2013) Michael J. Hurley et al. BRAIN
- MPP+-dependent inhibition ofIhreduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons
- (2013) A Masi et al. BRITISH JOURNAL OF PHARMACOLOGY
- Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease
- (2013) Patrick P. Michel et al. FASEB JOURNAL
- Structure–Activity Relationship of N,N′-Disubstituted Pyrimidinetriones as CaV1.3 Calcium Channel-Selective Antagonists for Parkinson’s Disease
- (2013) Soosung Kang et al. JOURNAL OF MEDICINAL CHEMISTRY
- 4-Aminopyridine improves freezing of gait in Parkinson’s disease
- (2013) Corneliu C. Luca et al. JOURNAL OF NEUROLOGY
- Randomized trial of safinamide add-on to levodopa in Parkinson's disease with motor fluctuations
- (2013) Rupam Borgohain et al. MOVEMENT DISORDERS
- Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model
- (2013) Daniel Alvarez-Fischer et al. PLoS One
- Convergent Ca2+and Zn2+signaling regulates apoptotic Kv2.1 K+currents
- (2013) Meghan C. McCord et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of MK-801 on recognition and neurodegeneration in an MPTP-induced Parkinson's rat model
- (2012) Ming-Hong Hsieh et al. BEHAVIOURAL BRAIN RESEARCH
- Glutamate Receptors as Therapeutic Targets for Parkinsons Disease
- (2012) Kari Johnson et al. CNS & Neurological Disorders-Drug Targets
- L-Type Voltage-Dependent Calcium Channels As Therapeutic Targets for Neurodegenerative Diseases
- (2012) T. Yagami et al. CURRENT MEDICINAL CHEMISTRY
- K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration
- (2012) Julia Schiemann et al. NATURE NEUROSCIENCE
- SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons
- (2012) J. Deignan et al. NEUROSCIENCE
- Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease
- (2012) Seung-Yeon Cho et al. PARKINSONISM & RELATED DISORDERS
- Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease
- (2011) Cameron H. Good et al. FASEB JOURNAL
- Bee Venom Reduces Neuroinflammation in the MPTP-Induced Model of Parkinson's Disease
- (2011) Jong-In Kim et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease
- (2011) E. Ilijic et al. NEUROBIOLOGY OF DISEASE
- L-Type Cav1.2 Calcium Channel is Involved in 6-Hydroxydopamine-Induced Neurotoxicity in Rats
- (2011) Rong Wang et al. NEUROTOXICITY RESEARCH
- Voltage-gated calcium channels and Parkinson's disease
- (2011) Michael J. Hurley et al. PHARMACOLOGY & THERAPEUTICS
- Is There a Recreational Misuse Potential for Pregabalin Analysis of Anecdotal Online Reports in Comparison with Related Gabapentin and Clonazepam Data
- (2011) Fabrizio Schifano et al. PSYCHOTHERAPY AND PSYCHOSOMATICS
- Phase-resetting curve determines how BK currents affect neuronal firing
- (2010) Cheng Ly et al. JOURNAL OF COMPUTATIONAL NEUROSCIENCE
- Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial
- (2010) Murat Emre et al. LANCET NEUROLOGY
- A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease
- (2010) C. Savio Chan et al. MOVEMENT DISORDERS
- Levodopa: the story so far
- (2010) Alison Abbott NATURE
- Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
- (2010) Jaime N. Guzman et al. NATURE
- Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease
- (2010) Christian Lüscher et al. NATURE REVIEWS NEUROSCIENCE
- Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons
- (2010) Bruno A. Benítez et al. NEUROPHARMACOLOGY
- Ca2+-Activated K+ Channels: From Protein Complexes to Function
- (2010) Henrike Berkefeld et al. PHYSIOLOGICAL REVIEWS
- MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease
- (2009) D. Galter et al. GENES BRAIN AND BEHAVIOR
- Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles
- (2009) Rongqin Huang et al. JOURNAL OF GENE MEDICINE
- Robust Pacemaking in Substantia Nigra Dopaminergic Neurons
- (2009) J. N. Guzman et al. JOURNAL OF NEUROSCIENCE
- Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial
- (2009) Dag Aarsland et al. LANCET NEUROLOGY
- Neuroprotective effects of bee venom pharmaceutical acupuncture in acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease
- (2009) Ah-Reum Doo et al. NEUROLOGICAL RESEARCH
- Hyperpolarization-Activated Cation Channels: From Genes to Function
- (2009) Martin Biel et al. PHYSIOLOGICAL REVIEWS
- Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease
- (2008) M. C. Pott Godoy et al. BRAIN
- Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety
- (2008) Sanjeev V Kothare et al. Expert Opinion on Drug Metabolism & Toxicology
- Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition
- (2008) Magnus J. Hansson et al. FREE RADICAL BIOLOGY AND MEDICINE
- Use of antihypertensives and the risk of Parkinson disease
- (2008) C. Becker et al. NEUROLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started