Review
Cell Biology
Lauren H. Fairley, Amandine Grimm, Anne Eckert
Summary: Intercellular mitochondria transfer is a novel form of cell signalling that plays an important role in brain disorders and is considered a potential therapeutic strategy.
Article
Oncology
Dongchen Wang, Peng Ye, Chaohua Kong, Yuelin Chao, Wande Yu, Xiaomin Jiang, Jie Luo, Yue Gu, Shao-Liang Chen
Summary: Endothelial dysfunction is an early step in atherosclerotic cardiovascular disease, and this study found that deficiency of Mfrn2 attenuates this dysfunction by reducing mitochondrial iron levels and dysfunction. The research suggests a potential therapeutic strategy against vascular endothelial dysfunction in atherosclerosis by targeting Mfrn2 and mitochondrial iron overload.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Elizabeta Nemeth, Tomas Ganz
Summary: Iron regulation in organisms is primarily controlled by the interaction of the iron-regulatory peptide hormone hepcidin and its receptor ferroportin, which plays a crucial role in maintaining iron homeostasis. Dysregulation of hepcidin can lead to iron overload disorders or iron deficiency, affecting iron delivery and compensatory erythropoiesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Nicola Romano, Giammarco Baiardi, Valeria Maria Pinto, Sabrina Quintino, Barbara Gianesin, Riccardo Sasso, Andrea Diociasi, Francesca Mattioli, Roberta Marchese, Giovanni Abbruzzese, Antonio Castaldi, Gian Luca Forni
Summary: Neurodegeneration with brain iron accumulation (NBIA) is a group of rare diseases characterized by brain iron overload. Current treatment options only focus on symptom management. The use of deferiprone (DFP) appears to be a promising strategy for reducing iron accumulation and improving clinical symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Shuzheng Tan, Ying Kong, Yongtong Xian, Pengbo Gao, Yue Xu, Chuzhong Wei, Peixu Lin, Weilong Ye, Zesong Li, Xiao Zhu
Summary: Ferroptosis is a newly discovered non-apoptotic cell death mode that is distinct from classical cell death modes. It is characterized by the accumulation of iron dependence and lipid peroxides. Identifying key sites of ferroptosis in diseases is crucial, and it is also linked to tumor development, providing personalized plans for cancer patients. Despite the need for further study on its mechanisms and side effects, ferroptosis remains a promising method for cancer treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Pharmacology & Pharmacy
Sirinart Kumfu, Jirapas Sripetchwandee, Chanisa Thonusin, Natticha Sumneang, Chayodom Maneechote, Busarin Arunsak, Titikorn Chunchai, Thura Tun Oo, Aphisek Kongkaew, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Iron overload cardiomyopathy (IOC) is the leading cause of death in patients with iron overload. This study indicates that ferroptosis may play a dominant role in IOC, and inhibiting ferroptosis could be a potential novel treatment for improving cardiac function in iron-overloaded rats.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hye Eun Lee, Min Kyo Jung, Seul Gi Noh, Hye Bin Choi, Se Hyun Chae, Jae Hyeok Lee, Ji Young Mun
Summary: Iron overload in the brain caused by a specific point mutation in the WD Repeat Domain 45 (WDR45) gene is associated with autophagy defects, altered organelle structures, and changes in the expression of genes related to lipid metabolism, mitochondrial function, and autophagy. The accumulation of iron primarily in lysosomal vesicles leads to impaired lipid metabolism, mitochondrial disorder, and unbalanced autophagy fluxes due to WDR45 deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Eddie Tam, Hye K. Sung, Gary Sweeney
Summary: Iron overload leads to insulin resistance in H9c2 cardiomyoblast cells. Overexpression of MitoNEET can protect against iron accumulation in the mitochondria and subsequent insulin resistance. Iron overload increases mitochondrial iron content, ROS production, mitochondrial fission, and decreases insulin-stimulated Akt and ERK1/2 phosphorylation. MitoNEET overexpression attenuates these effects and upregulates levels of PGC1 alpha protein.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Plant Sciences
Leah J. Kim, Kaitlyn M. Tsuyuki, Fengling Hu, Emily Y. Park, Jingwen Zhang, Jennifer G. Iraheta, Ju-Chen Chia, Rong Huang, Avery E. Tucker, Madeline Clyne, Claire Castellano, Angie Kim, Daniel D. Chung, Christopher T. DaVeiga, Elizabeth M. Parsons, Olena K. Vatamaniuk, Jeeyon Jeong
Summary: This study reveals the essential role of Arabidopsis ferroportin 3 (FPN3) in maintaining optimal iron homeostasis in mitochondria and chloroplasts. Lack of FPN3 leads to disrupted iron levels and abnormal ultrastructure in mitochondria, affecting plant growth under iron-deficient conditions.
Review
Biochemistry & Molecular Biology
Marta Zaninello, Camilla Bean
Summary: The specialized structure and function of neurons rely on the organization of the cytoskeleton and the transport system of mitochondria. Mitochondria provide energy and calcium buffering in neurons, and their distribution is regulated by a dynamic balance between active transport and stable docking. This review summarizes the mechanisms of selective mitochondrial transport in different neuronal compartments and the potential for intercellular transfer, which has promising implications in disease treatment.
Article
Cell Biology
Jingmin Che, Huanhuan Lv, Jiancheng Yang, Bin Zhao, Sibo Zhou, Tongyao Yu, Peng Shang
Summary: In this study, iron overload induced apoptosis in osteoblasts through activating ER stress, resulting in mitochondrial dysfunction. Pretreatment with NAC or TUDC attenuated cell apoptosis and restored protein expression related to iron metabolism.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Eddie Tam, Hye Kyoung Sung, Nhat Hung Lam, Sally You, Sungji Cho, Saher M. M. Ahmed, Ali A. A. Abdul-Sater, Gary Sweeney
Summary: Iron overload leads to cardiovascular diseases, including heart failure. This study showed that iron overload triggers cell death in H9c2 cells by promoting intracellular and mitochondrial iron accumulation and ROS production. The use of iron-binding fluorescent reporters and antioxidants reduced these effects, and decreased apoptosis and lytic cell death. Overexpression of the mitochondrial membrane protein MitoNEET lowered iron and ROS accumulation in the mitochondria, leading to reduced cell death in response to iron overload.
Article
Biochemistry & Molecular Biology
Paula Tena-Morraja, Guillem Rique-Pujol, Claudia Muller-Sanchez, Manuel Reina, Ofelia M. Martinez-Estrada, Francesc X. Soriano
Summary: Synaptic activity in the central nervous system consumes the most energy. New research reveals that an episode of synaptic activity increases mitochondrial bioenergetics by inducing the expression of iron metabolism genes, resulting in enhanced cellular and mitochondrial iron uptake. The study suggests a coordinated expression of synaptic plasticity programs and energy demands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sirinart Kumfu, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This study investigated the roles of LCN-2 and LCN-2 receptors as iron transporters in cardiomyocytes under iron overload conditions. LTCC and TTCC were found to play crucial roles in Fe2+ uptake, while DFP showed beneficial effects in both Fe2+ and Fe3+ overload conditions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Christine Fischer, Chiara Volani, Timea Komlodi, Markus Seifert, Egon Demetz, Lara Valente de Souza, Kristina Auer, Verena Petzer, Laura von Raffay, Patrizia Moser, Erich Gnaiger, Guenter Weiss
Summary: This study investigates the effects of dietary and genetic iron overload on mitochondrial function, revealing that iron accumulation promotes ROS production and impairs mitochondrial respiratory capacity. Differences in response to iron overload were observed in wildtype and genetic hemochromatosis model mice, suggesting the potential for iron reduction therapy to improve mitochondrial function.
Meeting Abstract
Biochemistry & Molecular Biology
Yuho Kim, Eric Lindberg, Christopher Bleck, Brian Glancy
Article
Toxicology
Murui Han, Mark Bohlke, Timothy Maher, Jonghan Kim
Summary: Exposure to heavy metals, particularly manganese, is a major concern in public health due to its neurotoxic effects. Studies have shown that alcohol consumption can increase brain manganese levels and up-regulate iron transporters, potentially increasing the risk of manganese neurotoxicity. Additionally, alcohol can affect hypoxic response and hepcidin expression, impacting iron transport and manganese uptake.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Fatima Cabral, Mustafa Al-Rahem, John Skaggs, Thushara A. Thomas, Naresh Kumar, Qian Wu, Paolo Fadda, Lianbo Yu, John M. Robinson, Jonghan Kim, Ekta Pandey, Xinghui Sun, Wael N. Jarjour, Murugesan V. S. Rajaram, Edward N. Harris, Latha P. Ganesan
Summary: The study revealed that Stab1 primarily facilitates the proactive clearance of LPS and limits TLR4-mediated inflammation, with TLR4 and Stab1 functionally opposing each other as LPS receptors. It suggests that endotoxemia can be controlled by optimizing LPS clearance by Stab1.
Article
Toxicology
Ruiying Cheng, Rajitha Gadde, Yingfang Fan, Neha Kulkarni, Nachiket Shevale, Kai Bao, Hak Soo Choi, Swati Betharia, Jonghan Kim
Summary: N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) is a lipophilic metal chelator and antioxidant used for mercury poisoning. It has shown potential in binding to other metals like lead and iron. In this study, it was found that NBMI selectively binds to ferrous iron, protecting neuroblastoma cells from high iron-mediated cytotoxicity and reducing reactive oxygen species. Furthermore, NBMI effectively reduced iron accumulation in the brain and liver of iron-loaded mice, with a superior safety profile compared to the commonly used iron chelator, DFP. These findings highlight the neuroprotective and therapeutic potential of NBMI for neurodegenerative diseases associated with brain iron accumulation.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Stella Ekaputri, Eun-Kyung Choi, Manuela Sabelli, Luisa Aring, Kelsie J. Green, Juoae Chang, Kai Bao, Hak Soo Choi, Shigeki Iwase, Jonghan Kime, Elena Corradini, Antonello Pietrangelo, Martin D. Burke, Young Ah Seo
Summary: This study shows that hinokitiol can serve as a surrogate transmembrane iron transporter and restore normal iron physiology in FPN1-deficient animals or primary cells from patients. It redistributes iron from the liver to red blood cells, increases hemoglobin and hematocrit, and activates the regulated ferritin proteolysis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Prasanna Katti, Alexander S. Hall, Hailey A. Parry, Peter T. Ajayi, Yuho Kim, T. Bradley Willingham, Christopher K. E. Bleck, Han Wen, Brian Glancy
Summary: This study uses advanced imaging and analysis techniques to show how mitochondria are accommodated within tightly packed sarcomere networks, revealing the influence of mitochondrial location and orientation on sarcomere structure and myofilament interactions.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Varun V. Dhorajia, Jonghan Kim, Yuho Kim
Summary: In this study, using a mouse model of HH, it was found that although HH leads to systemic iron overload, only mild iron overload was observed in the skeletal muscle. Additionally, molecular markers related to mitochondrial function and autophagy were upregulated in the HH skeletal muscle, suggesting altered mitochondrial metabolism in response to iron overload. These early adaptive responses may play an important role in supporting mitochondrial health before the development of skeletal muscle dysfunction in HH.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Medicine, Research & Experimental
Gregory Jones, Lingxue Zeng, Jonghan Kim
Summary: This study evaluated the absorption, distribution, and elimination of deferoxamine nanoparticles (DFO-NPs) in rats and found their potential in improving safety and efficacy. Predictive pharmacokinetic models were developed to describe the pharmacokinetics of DFO-NPs, providing information for preclinical development and clinical translation. Additionally, a novel mechanism of subcutaneous absorption directly into the systemic circulation was identified, offering a new strategy for enhancing drug exposure of nanotherapeutics.
MOLECULAR PHARMACEUTICS
(2023)
Editorial Material
Physiology
Oh Sung Kwon, Yuki Tamura, Yuho Kim
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Gregory Jones, Lingxue Zeng, Wesley R. Stiles, Seung Hun Park, Homan Kang, Hak Soo Choi, Jonghan Kim
Summary: In animal studies, DFO-NPs have shown promise in treating iron overload, and subcutaneous injection prolongs the drug's stay in the body without adverse effects, making it a viable administration route for patients.
