Epigenetic regulation in the neurogenic niche of the adult dentate gyrus

A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus

(2021) Masato Uemura et al.   Cell Reports

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease

(2021) Hannah Walgrave et al.   Cell Stem Cell

Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

(2020) Irune Diaz-Aparicio et al.   JOURNAL OF NEUROSCIENCE

JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells

(2020) Yongli Shan et al.   Nature Communications

A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain

(2020) Christin Suenkel et al.   Cell Reports

Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate

(2020) Preston R. Arnold et al.   Frontiers in Cell and Developmental Biology

DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons

(2020) Daniel Pensold et al.   CEREBRAL CORTEX

Epigenetic Modifications of GABAergic Interneurons Contribute to Deficits in Adult Hippocampus Neurogenesis and Depression-Like Behavior in Prenatally Stressed Mice

(2020) Haiquan Zhong et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Ultrastructural Details of Mammalian Chromosome Architecture

(2020) Nils Krietenstein et al.   MOLECULAR CELL

The functions of long non-coding RNAs in neural stem cell proliferation and differentiation

(2020) Yanfang Zhao et al.   Cell and Bioscience

Histone deacetylase inhibition promotes regenerative neurogenesis after stab wound injury in the adult zebrafish optic tectum

(2020) Mariko Kiyooka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases

(2020) Leina Lu et al.   MOLECULAR CELL

Efficient low-cost chromatin profiling with CUT&Tag

(2020) Hatice S. Kaya-Okur et al.   Nature Protocols

Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells

(2020) Brent Asrican et al.   NEURON

Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis

(2020) Aron T. Hill et al.   Scientific Reports

A Bisulfite-free Approach for Base-Resolution Analysis of Genomic 5-Carboxylcytosine

(2020) Janina Ličytė et al.   Cell Reports

The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction

(2019) Xiang Li et al.   NATURE NEUROSCIENCE

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

(2019) Daniel A. Berg et al.   CELL

Adult Neurogenesis, Glia, and the Extracellular Matrix

(2019) Elise C. Cope et al.   Cell Stem Cell

Advances in epigenetics link genetics to the environment and disease

(2019) Giacomo Cavalli et al.   NATURE

CUT&Tag for efficient epigenomic profiling of small samples and single cells

(2019) Hatice S. Kaya-Okur et al.   Nature Communications

FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes

(2019) Ekaterina Savchenko et al.   Scientific Reports

Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus

(2019) Pei-Pei Liu et al.   Stem Cell Reports

Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus

(2019) Jordi Fernandez-Albert et al.   NATURE NEUROSCIENCE

New insights into the regulatory roles of microRNAs in adult neurogenesis

(2019) Marta Esteves et al.   CURRENT OPINION IN PHARMACOLOGY

HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction

(2019) Xiao-Yu Sun et al.   Journal of Neuroinflammation

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

(2018) Xingli Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing

(2018) Hannah Hochgerner et al.   NATURE NEUROSCIENCE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

(2018) Patrick Z. Liu et al.   Frontiers in Neuroscience

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

Epigenetics Control Microglia Plasticity

(2018) Mathilde Cheray et al.   Frontiers in Cellular Neuroscience

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

(2018) Hailing Shi et al.   NATURE

5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells

(2018) Eun-Ang Raiber et al.   Nature Chemistry

Treating Brain Disorders by Targeting Adult Neural Stem Cells

(2018) Hechen Bao et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis

(2018) Laura Stappert et al.   Frontiers in Neuroscience

Gain of CTCF-Anchored Chromatin Loops Marks the Exit from Naive Pluripotency

(2018) Aleksandra Pękowska et al.   Cell Systems

Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis

(2017) Liping Li et al.   HUMAN MOLECULAR GENETICS

Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation

(2017) Meetu Wadhwa et al.   Journal of Neuroinflammation

Neuronal activity modifies the chromatin accessibility landscape in the adult brain

(2017) Yijing Su et al.   NATURE NEUROSCIENCE

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

(2017) Monika Piwecka et al.   SCIENCE

DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress

(2017) Bing Yao et al.   Nature Communications

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

(2017) Benedetta Artegiani et al.   Cell Reports

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

An analysis of dentate gyrus function (an update)

(2017) Raymond P. Kesner   BEHAVIOURAL BRAIN RESEARCH

Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes

(2017) Ana Jovičić et al.   PLoS One

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

(2016) William W Du et al.   CELL DEATH AND DIFFERENTIATION

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

(2016) A. Verkhratsky et al.   EMBO JOURNAL

Long non-coding RNA Malat1 promotes neurite outgrowth through activation of ERK/MAPK signalling pathway in N2a cells

(2016) Lei Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

(2016) Ageliki Tsagaratou et al.   NATURE IMMUNOLOGY

The biogenesis and emerging roles of circular RNAs

(2016) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fine processes of Nestin-GFP–positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculature

(2016) Jonathan Moss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis

(2016) Juan Song et al.   Cold Spring Harbor Perspectives in Biology

The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation

(2016) Jamie O. Brett et al.   Aging-US

Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics

(2015) Xingyu Lu et al.   CELL RESEARCH

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

(2015) Jaehoon Shin et al.   Cell Stem Cell

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

(2015) Xintian You et al.   NATURE NEUROSCIENCE

Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus

(2015) Hirofumi Noguchi et al.   NEUROSCIENCE RESEARCH

Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing

(2015) D. A. Cusanovich et al.   SCIENCE

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Hopx distinguishes hippocampal from lateral ventricle neural stem cells

(2015) Deqiang Li et al.   Stem Cell Research

Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond

(2015) Achim Breiling et al.   Epigenetics & Chromatin

miR379-410 cluster miRNAs regulate neurogenesis and neuronal migration by fine-tuning N-cadherin

(2014) L. Rago et al.   EMBO JOURNAL

Tilting the balance of M1/M2 microglial phenotypes: Inhibition of Ezh2 leads to decreased M1 and enhanced M2 phenotype

(2014) Edward Koellhoffer et al.   JOURNAL OF NEUROIMMUNOLOGY

Ezh2 Regulates Adult Hippocampal Neurogenesis and Memory

(2014) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

Untangling the Influences of Voluntary Running, Environmental Complexity, Social Housing and Stress on Adult Hippocampal Neurogenesis

(2014) Catherine-Alexandra Grégoire et al.   PLoS One

Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation

(2014) A. Tsagaratou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

(2014) Rosa Chiara Paolicelli et al.   Frontiers in Cellular Neuroscience

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

(2013) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition

(2013) Run-Rui Zhang et al.   Cell Stem Cell

Decoding Noncoding RNA

(2013) Kathryn Sandberg et al.   CIRCULATION RESEARCH

Polarized distribution of AMPA, but not GABAA, receptors in radial glia-like cells of the adult dentate gyrus

(2013) Roland Renzel et al.   GLIA

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

(2013) Andrii Rudenko et al.   NEURON

DNA methylation presents distinct binding sites for human transcription factors

(2013) Shaohui Hu et al.   eLife

Running-induced epigenetic and gene expression changes in the adolescent brain

(2012) Jean LeBeau Abel et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

(2012) Juan Song et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice

(2012) Francesco Matrisciano et al.   NEUROPHARMACOLOGY

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

CTCF Is Required for Neural Development and Stochastic Expression of Clustered Pcdh Genes in Neurons

(2012) Teruyoshi Hirayama et al.   Cell Reports

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase

(2012) Eun-Ang Raiber et al.   GENOME BIOLOGY

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

BDNF control of adult SVZ neurogenesis

(2011) Kevin G. Bath et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

(2011) William A. Pastor et al.   NATURE

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

miR-132 Mediates the Integration of Newborn Neurons into the Adult Dentate Gyrus

(2011) Bryan W. Luikart et al.   PLoS One

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Adult hippocampal neurogenesis and c-Fos induction during escalation of voluntary wheel running in C57BL/6J mice

(2010) Peter J. Clark et al.   BEHAVIOURAL BRAIN RESEARCH

Epigenetic Regulation of miR-184 by MBD1 Governs Neural Stem Cell Proliferation and Differentiation

(2010) Changmei Liu et al.   Cell Stem Cell

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Epigenetic regulation of neurogenesis in the adult hippocampus

(2010) M Covic et al.   HEREDITY

Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation

(2010) G. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Widespread transcription at neuronal activity-regulated enhancers

(2010) Tae-Kyung Kim et al.   NATURE

Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways

(2010) Antonella Riccio   NATURE NEUROSCIENCE

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: Unraveling the genome to understand the mind

(2010) Jenny Hsieh et al.   NEUROBIOLOGY OF DISEASE

Reversible Block of Mouse Neural Stem Cell Differentiation in the Absence of Dicer and MicroRNAs

(2010) Therese Andersson et al.   PLoS One

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Finding the fifth base: Genome-wide sequencing of cytosine methylation

(2009) R. Lister et al.   GENOME RESEARCH

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

(2009) R. L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development

(2008) Jessica L. MacDonald et al.   DEVELOPMENTAL DYNAMICS

Epigenetic Regulation of the Stem Cell Mitogen Fgf-2 by Mbd1 in Adult Neural Stem/Progenitor Cells

(2008) Xuekun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY