GPNMB mitigates Alzheimer’s disease and enhances autophagy via suppressing the mTOR signal

Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration

(2020) Kevin M. Budge et al.   MOLECULAR NEUROBIOLOGY

GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and β-catenin activity

(2019) Gordana Maric et al.   ONCOGENE

Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Ameliorates the Inflammatory Response in Periodontal Disease

(2019) Rong Song et al.   INFLAMMATION

Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy

(2019) Natalia N. Nalivaeva et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment

(2018) Candice E. Van Skike et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor

(2018) Matthew L. Neal et al.   Journal of Neuroinflammation

Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK)

(2018) Rolf Grempler et al.   PLoS One

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress

(2018) Elizabeth B. Moloney et al.   NEUROBIOLOGY OF DISEASE

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

(2018) Melanie Hüttenrauch et al.   Acta Neuropathologica Communications

Glycoprotein NMB: an Emerging Role in Neurodegenerative Disease

(2017) Kevin M. Budge et al.   MOLECULAR NEUROBIOLOGY

Autophagy and Alzheimer’s Disease

(2016) Qian Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The extracellular fragment of GPNMB (Glycoprotein nonmelanosoma protein B, osteoactivin) improves memory and increases hippocampal GluA1 levels in mice

(2015) Kenta Murata et al.   JOURNAL OF NEUROCHEMISTRY

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

(2015) Jihoon Nah et al.   MOLECULES AND CELLS

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Autophagy in Alzheimer’s disease

(2015) Ameneh Zare-shahabadi et al.   REVIEWS IN THE NEUROSCIENCES

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Autophagosome Formation and Molecular Mechanism of Autophagy

(2010) Isei Tanida   ANTIOXIDANTS & REDOX SIGNALING

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE