PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice

Cytokines, IBD, and Colitis-associated Cancer

(2015) Ralph Francescone et al.   INFLAMMATORY BOWEL DISEASES

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Downregulation of microRNA-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4

(2014) Y Yang et al.   CANCER GENE THERAPY

Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65

(2014) Soon-Kyung Hwang et al.   CARCINOGENESIS

LPS Induces the Degradation of Programmed Cell Death Protein 4 (PDCD4) to Release Twist2, Activating c-Maf Transcription to Promote Interleukin-10 Production

(2014) Mirjam W. M. van den Bosch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation

(2014) Bo Zhong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Embelin Reduces Colitis-Associated Tumorigenesis through Limiting IL-6/STAT3 Signaling

(2014) Y. Dai et al.   MOLECULAR CANCER THERAPEUTICS

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4

(2014) Olesja Fehler et al.   NUCLEIC ACIDS RESEARCH

A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation

(2014) A Biyanee et al.   ONCOGENE

Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development

(2014) Maximilian J. Waldner et al.   SEMINARS IN IMMUNOLOGY

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

(2014) Koji Taniguchi et al.   SEMINARS IN IMMUNOLOGY

Programmed Cell Death-4 Deficiency Prevents Diet-Induced Obesity, Adipose Tissue Inflammation, and Insulin Resistance

(2013) Q. Wang et al.   DIABETES

Genome-Wide Association Study of Ulcerative Colitis in Koreans Suggests Extensive Overlapping of Genetic Susceptibility With Caucasians

(2013) Suk-Kyun Yang et al.   INFLAMMATORY BOWEL DISEASES

The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury

(2013) Xiaoyan Wang et al.   LABORATORY INVESTIGATION

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells

(2013) I H Chan et al.   Mucosal Immunology

Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

(2013) Jürgen Scheller et al.   SEMINARS IN IMMUNOLOGY

Role of IL-17A in the development of colitis-associated cancer

(2012) Y. S. Hyun et al.   CARCINOGENESIS

Inflammation-Associated Cancer Development in Digestive Organs: Mechanisms and Roles for Genetic and Epigenetic Modulation

(2012) Tsutomu Chiba et al.   GASTROENTEROLOGY

Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression

(2012) Brian F. Zamarron et al.   International Journal of Biological Sciences

Interleukin-6 - A Key Regulator of Colorectal Cancer Development

(2012) Maximilian J. Waldner et al.   International Journal of Biological Sciences

Ulcerative colitis

(2012) Ingrid Ordás et al.   LANCET

Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer

(2012) Na Wei et al.   PLoS One

Inflammation and colorectal cancer: colitis-associated neoplasia

(2012) Sergei I. Grivennikov   Seminars in Immunopathology

Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation

(2011) Tobias Schmid et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic   cell death

(2011) Q. Ruan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation

(2009) Brigitte Lankat-Buttgereit et al.   BIOLOGY OF THE CELL

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

PDCD4 inhibits the malignant phenotype of ovarian cancer cells

(2009) Zeng-Tao Wei et al.   CANCER SCIENCE

Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

(2009) S. Matsumoto et al.   JOURNAL OF IMMUNOLOGY

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

(2009) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells

(2008) D.-S. Shin et al.   CANCER RESEARCH