Cytokines, IBD, and Colitis-associated Cancer

Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis

(2014) Xinyang Song et al.   IMMUNITY

Significant association between IL23R and IL17F polymorphisms and clinical features of colorectal cancer

(2014) Inés Omrane et al.   IMMUNOLOGY LETTERS

The roles of mesenchymal stem cells in tumor inflammatory microenvironment

(2014) Zhao Sun et al.   Journal of Hematology & Oncology

Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis

(2014) Eun Ran Kim   WORLD JOURNAL OF GASTROENTEROLOGY

The role IL-1 in tumor-mediated angiogenesis

(2014) Elena Voronov et al.   Frontiers in Physiology

Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction

(2013) T Nagasaki et al.   BRITISH JOURNAL OF CANCER

Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway

(2013) Liming Zhu et al.   CANCER LETTERS

Tumor-Derived GM-CSF Promotes Inflammatory Colon Carcinogenesis via Stimulating Epithelial Release of VEGF

(2013) Y. Wang et al.   CANCER RESEARCH

Proteome Profiling of Cancer-Associated Fibroblasts Identifies Novel Proinflammatory Signatures and Prognostic Markers for Colorectal Cancer

(2013) S. Torres et al.   CLINICAL CANCER RESEARCH

TH17 Cell Induction and Effects of IL-17A and IL-17F Blockade in Experimental Colitis

(2013) Esben Gjerløff Wedebye Schmidt et al.   INFLAMMATORY BOWEL DISEASES

Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK

(2013) Clemens Neufert et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

(2013) Stefanie Kirchberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of IL-1  in the Early Tumor Cell-Induced Angiogenic Response

(2013) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells

(2013) I H Chan et al.   Mucosal Immunology

An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

(2013) Alicia S Chung et al.   NATURE MEDICINE

The Yin and Yang of Toll-like receptors in cancer

(2013) J-P Pradere et al.   ONCOGENE

Mesenchymal Stem Cells Cancel Azoxymethane-Induced Tumor Initiation

(2013) Masanao Nasuno et al.   STEM CELLS

The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment

(2012) Jae Hak Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis

(2012) Y S Lee et al.   BRITISH JOURNAL OF CANCER

NF- B Activity Regulates Mesenchymal Stem Cell Accumulation at Tumor Sites

(2012) R. Uchibori et al.   CANCER RESEARCH

Role of IL-17A in the development of colitis-associated cancer

(2012) Y. S. Hyun et al.   CARCINOGENESIS

Mesenchymal-Stem-Cell-Induced Immunoregulation Involves FAS-Ligand-/FAS-Mediated T Cell Apoptosis

(2012) Kentaro Akiyama et al.   Cell Stem Cell

Mice That Express Human Interleukin-8 Have Increased Mobilization of Immature Myeloid Cells, Which Exacerbates Inflammation and Accelerates Colon Carcinogenesis

(2012) Samuel Asfaha et al.   GASTROENTEROLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Mesenchymal stem cells in the colorectal tumor microenvironment: Recent progress and implications

(2012) Niamh M. Hogan et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation

(2012) Olivier Boulard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts

(2012) L J A C Hawinkels et al.   ONCOGENE

A Protective Role by Interleukin-17F in Colon Tumorigenesis

(2012) Zan Tong et al.   PLoS One

Inflammation and colorectal cancer: colitis-associated neoplasia

(2012) Sergei I. Grivennikov   Seminars in Immunopathology

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

(2011) B. B. Aggarwal et al.   BLOOD

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Cytokines, Inflammation and Colon Cancer

(2011) L. Klampfer   CURRENT CANCER DRUG TARGETS

Involvement of interleukin-21 in the regulation of colitis-associated colon cancer

(2011) Carmine Stolfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice

(2011) J H Cox et al.   Mucosal Immunology

Ulcerative Colitis

(2011) Silvio Danese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiangiogenesis agents in colorectal cancer

(2010) Joleen Hubbard et al.   CURRENT OPINION IN ONCOLOGY

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohnʼs disease

(2010) S. C. Ng et al.   INFLAMMATORY BOWEL DISEASES

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis

(2010) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer

(2010) Maximilian J. Waldner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Cancer associated fibroblasts (CAFs) in tumor microenvironment

(2009) Fei Xing   Frontiers in Bioscience-Landmark

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

Genetic epistasis of IL23/IL17 pathway genes in Crohnʼs disease

(2009) Dermot P.B. McGovern et al.   INFLAMMATORY BOWEL DISEASES

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

(2009) S. Matsumoto et al.   JOURNAL OF IMMUNOLOGY

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE

Circulating Levels of Inflammatory Cytokines and Risk of Colorectal Adenomas

(2008) S. Kim et al.   CANCER RESEARCH

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Topical Implantation of Mesenchymal Stem Cells Has Beneficial Effects on Healing of Experimental Colitis in Rats

(2008) Y. Hayashi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Opposing functions of IKK  during acute and chronic intestinal inflammation

(2008) L. Eckmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohnʼs disease and analysis of the IL17F p.His161Arg polymorphism in IBD

(2007) Julia Seiderer et al.   INFLAMMATORY BOWEL DISEASES

TNF-mediated inflammatory disease

(2007) JR Bradley   JOURNAL OF PATHOLOGY