Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer’s disease

A case-control study of the locus coeruleus degeneration in Alzheimer's disease

(2021) Ruihua Hou et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

MRI‐assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction

(2021) Jeremy A. Elman et al.   Alzheimers & Dementia

In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline

(2021) Heidi I. L. Jacobs et al.   Science Translational Medicine

Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals

(2020) Firoza Z. Lussier et al.   Alzheimers & Dementia

18F-MK-6240 PET for early and late detection of neurofibrillary tangles

(2020) Tharick A Pascoal et al.   BRAIN

Determining Amyloid-β positivity using [18F]AZD4694 PET imaging

(2020) Joseph Therriault et al.   JOURNAL OF NUCLEAR MEDICINE

Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm

(2020) Heidi IL Jacobs et al.   eLife

Locus coeruleus: a new look at the blue spot

(2020) Gina R. Poe et al.   NATURE REVIEWS NEUROSCIENCE

Topographical distribution of amyloid-β, tau and atrophy in behavioral / dysexecutive AD patients

(2020) Joseph Therriault et al.   NEUROLOGY

Association between neuromelanin-sensitive MRI signal and psychomotor slowing in late-life depression

(2020) Kenneth Wengler et al.   NEUROPSYCHOPHARMACOLOGY

What’s That (Blue) Spot on my MRI? Multimodal Neuroimaging of the Locus Coeruleus in Neurodegenerative Disease

(2020) Michael Kelberman et al.   Frontiers in Neuroscience

Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue

(2019) Cinthya Aguero et al.   Acta Neuropathologica Communications

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

(2019) Janina Krell-Roesch et al.   Translational Psychiatry

Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

(2019) Clifford M. Cassidy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetic resonance imaging of noradrenergic neurons

(2019) Takashi Watanabe et al.   Brain Structure & Function

Alzheimer’s disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms

(2019) Heidi I. L. Jacobs et al.   MOLECULAR PSYCHIATRY

Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

(2019) Pauline Olivieri et al.   Annals of Clinical and Translational Neurology

Cerebrospinal Fluid Correlates of Neuropsychiatric Symptoms in Patients with Alzheimer’s Disease/Mild Cognitive Impairment: A Systematic Review

(2019) Alireza Showraki et al.   JOURNAL OF ALZHEIMERS DISEASE

Reliability and Validity of the Chinese Version of the Mild Behavioral Impairment Checklist for Screening for Alzheimer’s Disease

(2019) Yue Cui et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β

(2019) Joseph Therriault et al.   JAMA Neurology

The neurochemistry of agitation in Alzheimer’s disease: a systematic review

(2018) Kathy Y. Liu et al.   AGEING RESEARCH REVIEWS

High-resolution in vivo imaging of human locus coeruleus by magnetization transfer MRI at 3T and 7T

(2018) Nikos Priovoulos et al.   NEUROIMAGE

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

(2018) David Weinshenker   TRENDS IN NEUROSCIENCES

Brain Region-Specific Monoaminergic Correlates of Neuropsychiatric Symptoms in Alzheimer's Disease

(2018) Yannick Vermeiren et al.   JOURNAL OF ALZHEIMERS DISEASE

Assessing Mild Behavioral Impairment with the Mild Behavioral Impairment-Checklist in People with Mild Cognitive Impairment

(2018) Sabela C. Mallo et al.   JOURNAL OF ALZHEIMERS DISEASE

In vivo quantification of neurofibrillary tangles with [18F]MK-6240

(2018) Tharick A. Pascoal et al.   Alzheimers Research & Therapy

Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study

(2017) Jennifer R. Gatchel et al.   JOURNAL OF ALZHEIMERS DISEASE

The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations

(2017) Zahinoor Ismail et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher locus coeruleus MRI contrast is associated with lower parasympathetic influence over heart rate variability

(2017) Mara Mather et al.   NEUROIMAGE

Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats

(2017) Stefan Hirschberg et al.   eLife

The locus coeruleus neuroprotective drug vindeburnol normalizes behavior in the 5xFAD transgenic mouse model of Alzheimer’s disease

(2017) David Braun et al.   BRAIN RESEARCH

Roles of tau pathology in the locus coeruleus (LC) in age-associated pathophysiology and Alzheimer’s disease pathogenesis: Potential strategies to protect the LC against aging

(2017) Akiko Satoh et al.   BRAIN RESEARCH

Neuropsychiatric Disturbances in Alzheimer's Disease: What Have We Learned from Neuropathological Studies?

(2016) Debby Van Dam et al.   Current Alzheimer Research

Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine

(2016) Patricia Szot et al.   NEUROPHARMACOLOGY

Histologic validation of locus coeruleus MRI contrast in post-mortem tissue

(2015) Noam I. Keren et al.   NEUROIMAGE

Noradrenergic dysfunction in Alzheimer's disease

(2015) Mary Gannon et al.   Frontiers in Neuroscience

Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: High-resolution fast spin-echo T1-weighted imaging

(2014) Junko Takahashi et al.   Geriatrics & Gerontology International

Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach

(2014) Xiangchuan Chen et al.   MAGNETIC RESONANCE IMAGING

The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease

(2013) Daniel García-Lorenzo et al.   BRAIN

Head-to-Head Comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for  -Amyloid Imaging in Aging and Dementia

(2013) C. C. Rowe et al.   JOURNAL OF NUCLEAR MEDICINE

Clinical Validation of 18F-AZD4694, an Amyloid- -Specific PET Radioligand

(2012) Z. Cselenyi et al.   JOURNAL OF NUCLEAR MEDICINE

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Neuropsychiatric symptoms in Alzheimer’s disease

(2011) Constantine G. Lyketsos et al.   Alzheimers & Dementia

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sertraline for the Treatment of Depression in Alzheimer Disease: Week-24 Outcomes

(2010) Daniel Weintraub et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Prazosin for the Treatment of Behavioral Symptoms in Patients With Alzheimer Disease With Agitation and Aggression

(2009) Lucy Y. Wang et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Visual discrimination among patients with depression and schizophrenia and healthy individuals using semiquantitative color-coded fast spin-echo T1-weighted magnetic resonance imaging

(2009) Makoto Sasaki et al.   NEURORADIOLOGY

Efficacy of Second Generation Antidepressants in Late-Life Depression: A Meta-Analysis of the Evidence

(2008) J Craig Nelson et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part II: Physiological and Pharmacological Manipulations and Pathological Alterations of Locus Coeruleus Activity in Humans

(2008) E. Samuels et al.   Current Neuropharmacology