Locus coeruleus: a new look at the blue spot

Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors

(2020) Rachel P. Tillage et al.   Brain Structure & Function

A Role for the Locus Coeruleus in Hippocampal CA1 Place Cell Reorganization during Spatial Reward Learning

(2020) Alexandra Mansell Kaufman et al.   NEURON

Sleep Changes Across the Female Hormonal Cycle Affecting Memory: Implications for Resilient Adaptation to Traumatic Experiences

(2020) Yesenia Cabrera et al.   JOURNAL OF WOMENS HEALTH

Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep

(2020) Hanna Hayat et al.   Science Advances

A possible role of the norepinephrine system during sequential cognitive flexibility – Evidence from EEG and pupil diameter data

(2020) Franziska Giller et al.   CORTEX

An Intersectional Viral-Genetic Method for Fluorescent Tracing of Axon Collaterals Reveals Details of Noradrenergic Locus Coeruleus Structure

(2020) Nicholas W. Plummer et al.   eNeuro

Active control of arousal by a locus coeruleus GABAergic circuit

(2019) Vincent Breton-Provencher et al.   NATURE NEUROSCIENCE

Receptor and circuit mechanisms underlying differential procognitive actions of psychostimulants

(2019) Robert C. Spencer et al.   NEUROPSYCHOPHARMACOLOGY

Locus Coeruleus tracking of prediction errors optimises cognitive flexibility: An Active Inference model

(2019) Anna C. Sales et al.   PLoS Computational Biology

A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine

(2019) Jiesi Feng et al.   NEURON

Distinct regional patterns in noradrenergic innervation of the rat prefrontal cortex

(2019) Juan-Carlos Cerpa et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Lofexidine: A Newly FDA-Approved, Nonopioid Treatment for Opioid Withdrawal

(2019) Bennett Doughty et al.   ANNALS OF PHARMACOTHERAPY

Dissecting the Catecholamines: How New Approaches Will Facilitate the Distinction between Noradrenergic and Dopaminergic Systems

(2019) Karl T. Schmidt et al.   ACS Chemical Neuroscience

DREADD-mediated modulation of locus coeruleus inputs to mPFC improves strategy set-shifting

(2019) Zackary A. Cope et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Atomoxetine improves attentional orienting in a predictive context

(2019) Amélie J. Reynaud et al.   NEUROPHARMACOLOGY

Control of entropy in neural models of environmental state

(2019) Timothy H Muller et al.   eLife

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

(2019) Matthew J Betts et al.   BRAIN

Restless REM Sleep Impedes Overnight Amygdala Adaptation

(2019) Rick Wassing et al.   CURRENT BIOLOGY

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation

(2019) Valerio Zerbi et al.   NEURON

An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

(2019) Abhinaba Ghosh et al.   Alzheimers Research & Therapy

Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons

(2019) Sanlan Li et al.   Cell Reports

Axonal projection‐specific differences in somatodendritic α2 autoreceptor function in locus coeruleus neurons

(2019) Tobias A. Wagner‐Altendorf et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuromodulation in circuits of aversive emotional learning

(2019) Ekaterina Likhtik et al.   NATURE NEUROSCIENCE

The noradrenergic system is necessary for survival of vulnerable midbrain dopaminergic neurons: Implications for development and Parkinson’s disease

(2019) Oum K. Hassani et al.   NEUROBIOLOGY OF AGING

Rostral locus coeruleus integrity is associated with better memory performance in older adults

(2019) Martin J. Dahl et al.   Nature Human Behaviour

Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture

(2019) Dan J. Chandler et al.   JOURNAL OF NEUROSCIENCE

Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning

(2019) Matthew B. Pomrenze et al.   Cell Reports

Noradrenaline Modulates Visual Perception and Late Visually Evoked Activity

(2018) Hagar Gelbard-Sagiv et al.   CURRENT BIOLOGY

Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators

(2018) Huan Wang et al.   CURRENT OPINION IN NEUROBIOLOGY

The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism

(2018) B. Sofia Beas et al.   NATURE NEUROSCIENCE

Dual contributions of noradrenaline to behavioural flexibility and motivation

(2018) Caroline I. Jahn et al.   PSYCHOPHARMACOLOGY

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

(2018) David Weinshenker   TRENDS IN NEUROSCIENCES

A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia

(2018) Martin Timo Henrich et al.   Acta Neuropathologica Communications

Noradrenergic Transmission at Alpha1-Adrenergic Receptors in the Ventral Periaqueductal Gray Modulates Arousal

(2018) Kirsten A. Porter-Stransky et al.   BIOLOGICAL PSYCHIATRY

The locus coeruleus-norepinephrine system and sensory signal processing: A historical review and current perspectives

(2018) Barry D. Waterhouse et al.   BRAIN RESEARCH

Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer’s Disease

(2018) Alexander J. Ehrenberg et al.   JOURNAL OF ALZHEIMERS DISEASE

The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System

(2018) Nelson K. Totah et al.   NEURON

Phasic locus coeruleus activity regulates cortical encoding of salience information

(2018) Elena M. Vazey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis

(2018) Laura M. Butkovich et al.   Frontiers in Neuroscience

Noradrenergic ensemble-based modulation of cognition over multiple timescales

(2018) Nelson K.B. Totah et al.   BRAIN RESEARCH

Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory

(2018) Kevin M. Swift et al.   CURRENT BIOLOGY

Locus Coeruleus Phasic, But Not Tonic, Activation Initiates Global Remapping in a Familiar Environment

(2018) Stephanie L. Grella et al.   JOURNAL OF NEUROSCIENCE

Sleep to Remember

(2017) Susan J. Sara   JOURNAL OF NEUROSCIENCE

Sleep Is for Forgetting

(2017) Gina R. Poe   JOURNAL OF NEUROSCIENCE

Modular organization of the brainstem noradrenaline system coordinates opposing learning states

(2017) Akira Uematsu et al.   NATURE NEUROSCIENCE

Multimodal profiling of single-cell morphology, electrophysiology, and gene expression using Patch-seq

(2017) Cathryn R Cadwell et al.   Nature Protocols

The neurobiology of safety and threat learning in infancy

(2017) Jacek Debiec et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Targeting the norepinephrinergic system in Parkinson's disease and related disorders: The locus coeruleus story

(2017) Yannick Vermeiren et al.   NEUROCHEMISTRY INTERNATIONAL

Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context

(2017) Akiko Wagatsuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Subpopulations of Noradrenergic Neurons in the Locus Coeruleus Complex Distinguished by Expression of the Dorsal Neural Tube Marker Pax7

(2017) Nicholas W. Plummer et al.   Frontiers in Neuroanatomy

Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats

(2017) Stefan Hirschberg et al.   eLife

Both Duration and Timing of Sleep are Important to Memory Consolidation

(2017) Gina R. Poe et al.   SLEEP

Uncovering diversity in the development of central noradrenergic neurons and their efferents

(2016) Sabrina D. Robertson et al.   BRAIN RESEARCH

Heterogeneous organization and function of the central noradrenergic system

(2016) Barry D. Waterhouse et al.   BRAIN RESEARCH

Differential cognitive actions of norepinephrine a2 and a1 receptor signaling in the prefrontal cortex

(2016) Craig W. Berridge et al.   BRAIN RESEARCH

Norepinephrine at the nexus of arousal, motivation and relapse

(2016) Rodrigo A. España et al.   BRAIN RESEARCH

β-Adrenergic Control of Hippocampal Function: Subserving the Choreography of Synaptic Information Storage and Memory

(2016) Hardy Hagena et al.   CEREBRAL CORTEX

Locus coeruleus and dopaminergic consolidation of everyday memory

(2016) Tomonori Takeuchi et al.   NATURE

Relationships between Pupil Diameter and Neuronal Activity in the Locus Coeruleus, Colliculi, and Cingulate Cortex

(2016) Siddhartha Joshi et al.   NEURON

High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA

(2016) Justus M. Kebschull et al.   NEURON

Methylphenidate Enhances Early-Stage Sensory Processing and Rodent Performance of a Visual Signal Detection Task

(2016) Rachel L Navarra et al.   NEUROPSYCHOPHARMACOLOGY

Sex Differences in μ-Opioid Receptor Regulation of the Rat Locus Coeruleus and Their Cognitive Consequences

(2016) Herminio M Guajardo et al.   NEUROPSYCHOPHARMACOLOGY

Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory

(2016) Kimberly A. Kempadoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex

(2016) Jacob Reimer et al.   Nature Communications

Electrochemical Analysis of Neurotransmitters

(2015) Elizabeth S. Bucher et al.   Annual Review of Analytical Chemistry

Locus Coeruleus in time with the making of memories

(2015) Susan J Sara   CURRENT OPINION IN NEUROBIOLOGY

Hippocampal long-term potentiation that is elicited by perforant path stimulation or that occurs in conjunction with spatial learning is tightly controlled by beta-adrenoreceptors and the locus coeruleus

(2015) Niels Hansen et al.   HIPPOCAMPUS

Noradrenaline and Dopamine Neurons in the Reward/Effort Trade-Off: A Direct Electrophysiological Comparison in Behaving Monkeys

(2015) C. Varazzani et al.   JOURNAL OF NEUROSCIENCE

Sensitivity of Locus Ceruleus Neurons to Reward Value for Goal-Directed Actions

(2015) S. Bouret et al.   JOURNAL OF NEUROSCIENCE

Atomoxetine in patients with ADHD: A clinical and pharmacological review of the onset, trajectory, duration of response and implications for patients

(2015) David B Clemow et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Viral-genetic tracing of the input–output organization of a central noradrenaline circuit

(2015) Lindsay A. Schwarz et al.   NATURE

Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex

(2015) Ana Raquel O Martins et al.   NATURE NEUROSCIENCE

CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety

(2015) Jordan G. McCall et al.   NEURON

Performance monitoring and behavioral adaptation during task switching: An fMRI study

(2015) J. von der Gablentz et al.   NEUROSCIENCE

Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task

(2015) Kathrin Janitzky et al.   Frontiers in Behavioral Neuroscience

Behavioral Variability through Stochastic Choice and Its Gating by Anterior Cingulate Cortex

(2014) Dougal G.R. Tervo et al.   CELL

Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of  -Adrenergic Receptors

(2014) N. Hansen et al.   CEREBRAL CORTEX

Phasic Activation of Individual Neurons in the Locus Ceruleus/Subceruleus Complex of Monkeys Reflects Rewarded Decisions to Go But Not Stop

(2014) Rishi M. Kalwani et al.   JOURNAL OF NEUROSCIENCE

Vagus nerve stimulation…25 years later! What do we know about the effects on cognition?

(2014) Kristl Vonck et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

α1-Adrenergic receptor subtypes in the central nervous system: insights from genetically engineered mouse models

(2014) Irena Nalepa et al.   Pharmacological Reports

Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices

(2014) D. J. Chandler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons

(2014) Daniel J. Chandler et al.   Frontiers in Neural Circuits

Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD

(2014) William M. Vanderheyden et al.   EXPERIMENTAL BRAIN RESEARCH

Interaction of theADRB2Gene Polymorphism With Childhood Trauma in Predicting Adult Symptoms of Posttraumatic Stress Disorder

(2014) Israel Liberzon et al.   JAMA Psychiatry

Locus Coeruleus Stimulation Recruits a Broad Cortical Neuronal Network and Increases Cortical Perfusion

(2013) X. Toussay et al.   JOURNAL OF NEUROSCIENCE

Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus

(2012) M. Shi et al.   JOURNAL OF CELL SCIENCE

Evidence for a regional specificity in the density and distribution of noradrenergic varicosities in rat cortex

(2012) Kara L. Agster et al.   JOURNAL OF COMPARATIVE NEUROLOGY

L-threo-3,4-dihydroxyphenylserine (L-DOPS) co-administered with entacapone improves freezing of gait in Parkinson’s disease

(2012) Kei Fukada et al.   MEDICAL HYPOTHESES

Rational regulation of learning dynamics by pupil-linked arousal systems

(2012) Matthew R Nassar et al.   NATURE NEUROSCIENCE

Orienting and Reorienting: The Locus Coeruleus Mediates Cognition through Arousal

(2012) Susan J. Sara et al.   NEURON

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

(2012) Mitsuko Watabe-Uchida et al.   NEURON

Psychostimulants and motivated behavior: Arousal and cognition

(2012) Craig W. Berridge et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Noradrenergic modulation of wakefulness/arousal

(2012) Craig W. Berridge et al.   SLEEP MEDICINE REVIEWS

Noradrenergic ‘Tone’ Determines Dichotomous Control of Cortical Spike-Timing-Dependent Plasticity

(2012) Humberto Salgado et al.   Scientific Reports

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks

(2011) Amy F.T. Arnsten   BIOLOGICAL PSYCHIATRY

Noradrenergic Neurons of the Locus Coeruleus Are Phase Locked to Cortical Up-Down States during Sleep

(2011) Oxana Eschenko et al.   CEREBRAL CORTEX

Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons

(2011) Andre L. Curtis et al.   NEUROPHARMACOLOGY

Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility

(2011) Kevin Snyder et al.   NEUROPSYCHOPHARMACOLOGY

Stress-Related Noradrenergic Activity Prompts Large-Scale Neural Network Reconfiguration

(2011) E. J. Hermans et al.   SCIENCE

Pupil dilation signals surprise: evidence for noradrenaline’s role in decision making

(2011) Kerstin Preuschoff   Frontiers in Neuroscience

Noradrenergic modulation of behavioral odor detection and discrimination thresholds in the olfactory bulb

(2010) Olga Escanilla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pupil Diameter Predicts Changes in the Exploration–Exploitation Trade-off: Evidence for the Adaptive Gain Theory

(2010) Marieke Jepma et al.   JOURNAL OF COGNITIVE NEUROSCIENCE

Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology

(2010) D A Bangasser et al.   MOLECULAR PSYCHIATRY

Tuning arousal with optogenetic modulation of locus coeruleus neurons

(2010) Matthew E Carter et al.   NATURE NEUROSCIENCE

Locus Coeruleus Activation Facilitates Memory Encoding and Induces Hippocampal LTD that Depends on  -Adrenergic Receptor Activation

(2009) N. Lemon et al.   CEREBRAL CORTEX

Convergent regulation of locus coeruleus activity as an adaptive response to stress

(2008) Rita J. Valentino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Challenge-driven attention: Interacting frontal and brainstem systems

(2008) Rajeev D. S. Raizada   Frontiers in Human Neuroscience

Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting

(2008) J. McGaughy et al.   NEUROSCIENCE