What’s That (Blue) Spot on my MRI? Multimodal Neuroimaging of the Locus Coeruleus in Neurodegenerative Disease

Spatial patterns of tau deposition are associated with amyloid, ApoE, sex, and cognitive decline in older adults

(2020) Joana B. Pereira et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo anatomical mapping of human locus coeruleus functional connectivity at 3 T MRI

(2020) Thomas Liebe et al.   HUMAN BRAIN MAPPING

Indexing brain state-dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording

(2020) Patricia Pais-Roldán et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

(2020) Fang Zhang et al.   Science Translational Medicine

The Decline in Intrinsic Connectivity Between the Salience Network and Locus Coeruleus in Older Adults: Implications for Distractibility

(2020) Tae-Ho Lee et al.   Frontiers in Aging Neuroscience

Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization

(2020) Francesca Mandino et al.   Frontiers in Neuroinformatics

Relationship between cortical iron and tau aggregation in Alzheimer’s disease

(2020) Nicola Spotorno et al.   BRAIN

Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein

(2020) Yasunari Seita et al.   JOURNAL OF ALZHEIMERS DISEASE

Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model

(2020) Masafumi Shimojo et al.   JOURNAL OF NEUROSCIENCE

Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease

(2020) Inés Del Cerro et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus

(2020) Roger Pamphlett et al.   PLoS One

Impaired Phasic Discharge of Locus Coeruleus Neurons Based on Persistent High Tonic Discharge—A New Hypothesis With Potential Implications for Neurodegenerative Diseases

(2020) Kathrin Janitzky   Frontiers in Neurology

Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep

(2020) Hanna Hayat et al.   Science Advances

Age-related changes in the functional integrity of the phasic alerting system: a pupillometric investigation

(2020) Mingjian He et al.   NEUROBIOLOGY OF AGING

Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm

(2020) Heidi IL Jacobs et al.   eLife

The (Un)Conscious Mouse as a Model for Human Brain Functions: Key Principles of Anesthesia and Their Impact on Translational Neuroimaging

(2020) Henning M. Reimann et al.   Frontiers in Systems Neuroscience

Active control of arousal by a locus coeruleus GABAergic circuit

(2019) Vincent Breton-Provencher et al.   NATURE NEUROSCIENCE

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease

(2019) Rik Ossenkoppele et al.   NEUROLOGY

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

(2019) Iria Carballo-Carbajal et al.   Nature Communications

Radiosynthesis and Preclinical Evaluation of an α2A-Adrenoceptor Tracer Candidate, 6-[18F]Fluoro-marsanidine

(2019) Anna Krzyczmonik et al.   MOLECULAR IMAGING AND BIOLOGY

Magnetic resonance imaging of noradrenergic neurons

(2019) Takashi Watanabe et al.   Brain Structure & Function

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

(2019) Matthew J Betts et al.   BRAIN

Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease

(2019) Miquel Vila   MOVEMENT DISORDERS

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation

(2019) Valerio Zerbi et al.   NEURON

Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

(2019) Pauline Olivieri et al.   Annals of Clinical and Translational Neurology

Rostral locus coeruleus integrity is associated with better memory performance in older adults

(2019) Martin J. Dahl et al.   Nature Human Behaviour

Multimodal Magnetic Resonance Imaging Quantification of Brain Changes in Progressive Supranuclear Palsy

(2019) Nadya Pyatigorskaya et al.   MOVEMENT DISORDERS

Pupillary dilation responses as a midlife indicator of risk for Alzheimer's disease: association with Alzheimer's disease polygenic risk

(2019) William S. Kremen et al.   NEUROBIOLOGY OF AGING

Characterization of age-related microstructural changes in locus coeruleus and substantia nigra pars compacta

(2019) Jason Langley et al.   NEUROBIOLOGY OF AGING

Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus

(2019) Seong Su Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease

(2019) Amy F. T. Arnsten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pink1 −/− Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology

(2018) Kaylee P. Cullen et al.   DYSPHAGIA

Neuromelanin-sensitive magnetic resonance imaging features of the substantia nigra and locus coeruleus in de novo Parkinson's disease and its phenotypes

(2018) J. Wang et al.   EUROPEAN JOURNAL OF NEUROLOGY

In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study

(2018) Karoline Knudsen et al.   LANCET NEUROLOGY

Decreased noradrenaline transporter density in the motor cortex of Parkinson's disease patients

(2018) Michael Sommerauer et al.   MOVEMENT DISORDERS

Curvilinear locus coeruleus functional connectivity trajectories over the adult lifespan: a 7T MRI study

(2018) Heidi I.L. Jacobs et al.   NEUROBIOLOGY OF AGING

The spectrum of preclinical Alzheimer’s pathology and its modulation by ApoE genotype

(2018) Olga Pletnikova et al.   NEUROBIOLOGY OF AGING

High-resolution in vivo imaging of human locus coeruleus by magnetization transfer MRI at 3T and 7T

(2018) Nikos Priovoulos et al.   NEUROIMAGE

Functional connectivity under six anesthesia protocols and the awake condition in rat brain

(2018) Jaakko Paasonen et al.   NEUROIMAGE

Quantitative Analysis of Catecholamines in the Pink1 −/− Rat Model of Early-onset Parkinson’s Disease

(2018) Cynthia A. Kelm-Nelson et al.   NEUROSCIENCE

18 F-labeled norepinephrine transporter tracer [ 18 F]NS12137: radiosynthesis and preclinical evaluation

(2018) Anna K. Kirjavainen et al.   NUCLEAR MEDICINE AND BIOLOGY

Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events

(2018) Dorothea Hämmerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

(2018) David Weinshenker   TRENDS IN NEUROSCIENCES

Early brain connectivity alterations and cognitive impairment in a rat model of Alzheimer’s disease

(2018) Emma Muñoz-Moreno et al.   Alzheimers Research & Therapy

Pupillary Response to Cognitive Demand in Parkinson’s Disease: A Pilot Study

(2018) Melike Kahya et al.   Frontiers in Aging Neuroscience

Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer’s Disease

(2018) Alexander J. Ehrenberg et al.   JOURNAL OF ALZHEIMERS DISEASE

In vivo mapping of brainstem nuclei functional connectivity disruption in Alzheimer's disease

(2018) Laura Serra et al.   NEUROBIOLOGY OF AGING

Age-related accumulation of toxic metals in the human locus ceruleus

(2018) Roger Pamphlett et al.   PLoS One

Noradrenergic Hypothesis Linking Neurodegeneration-Based Cognitive Decline and Astroglia

(2018) Giampiero Leanza et al.   Frontiers in Molecular Neuroscience

In vivo visualization of age-related differences in the locus coeruleus

(2018) Kathy Y. Liu et al.   NEUROBIOLOGY OF AGING

In search of early neuroradiological biomarkers for Parkinson’s Disease: Alterations in resting state functional connectivity and gray matter microarchitecture in PINK1 −/− rats

(2018) Xuezhu Cai et al.   BRAIN RESEARCH

Early functional connectivity deficits and progressive microstructural alterations in the TgF344-AD rat model of Alzheimer’s Disease: A longitudinal MRI study

(2018) Cynthia Anckaerts et al.   NEUROBIOLOGY OF DISEASE

Nonhuman Primate Models of Neurodegenerative Disorders

(2017) Marina E Emborg   ILAR JOURNAL

Pupillary Responses as a Biomarker of Early Risk for Alzheimer’s Disease

(2017) Eric L. Granholm et al.   JOURNAL OF ALZHEIMERS DISEASE

Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates

(2017) Adriana Galvan et al.   JOURNAL OF NEURAL TRANSMISSION

α-Synuclein nonhuman primate models of Parkinson’s disease

(2017) David J. Marmion et al.   JOURNAL OF NEURAL TRANSMISSION

Noradrenergic Deficits in Parkinson Disease Imaged with11C-MeNER

(2017) Adjmal Nahimi et al.   JOURNAL OF NUCLEAR MEDICINE

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases

(2017) Céline Vermeiren et al.   MOVEMENT DISORDERS

Modular organization of the brainstem noradrenaline system coordinates opposing learning states

(2017) Akira Uematsu et al.   NATURE NEUROSCIENCE

Emotional arousal and recognition memory are differentially reflected in pupil diameter responses during emotional memory for negative events in younger and older adults

(2017) Dorothea Hämmerer et al.   NEUROBIOLOGY OF AGING

In vivo MRI assessment of the human locus coeruleus along its rostrocaudal extent in young and older adults

(2017) Matthew J. Betts et al.   NEUROIMAGE

Magnetic resonance imaging of the human locus coeruleus: A systematic review

(2017) Kathy Y. Liu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Dynamic Lateralization of Pupil Dilation Evoked by Locus Coeruleus Activation Results from Sympathetic, Not Parasympathetic, Contributions

(2017) Yang Liu et al.   Cell Reports

Investigating Focal Connectivity Deficits in Alzheimer's Disease Using Directional Brain Networks Derived from Resting-State fMRI

(2017) Sinan Zhao et al.   Frontiers in Aging Neuroscience

Characterization of tau positron emission tomography tracer [ 18 F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias

(2016) Kerstin Sander et al.   Alzheimers & Dementia

The coeruleus/subcoeruleus complex in idiopathic rapid eye movement sleep behaviour disorder

(2016) Mickael Ehrminger et al.   BRAIN

Excitotoxicity in ALS: Overstimulation, or overreaction?

(2016) Anna E. King et al.   EXPERIMENTAL NEUROLOGY

Differential involvement of brainstem noradrenergic and midbrain dopaminergic nuclei in cognitive control

(2016) Stefanie Köhler et al.   HUMAN BRAIN MAPPING

Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models

(2016) M. Brendel et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

(2016) E. D. Hostetler et al.   JOURNAL OF NUCLEAR MEDICINE

Neuromelanin marks the spot: identifying a locus coeruleus biomarker of cognitive reserve in healthy aging

(2016) David V. Clewett et al.   NEUROBIOLOGY OF AGING

Functional connectivity and network analysis of midbrain and brainstem nuclei

(2016) Karl-Jürgen Bär et al.   NEUROIMAGE

Tau PET in Alzheimer disease and mild cognitive impairment

(2016) Hanna Cho et al.   NEUROLOGY

Relationships between Pupil Diameter and Neuronal Activity in the Locus Coeruleus, Colliculi, and Cingulate Cortex

(2016) Siddhartha Joshi et al.   NEURON

Isoflurane anesthesia exacerbates learning and memory impairment in zinc-deficient APP/PS1 transgenic mice

(2016) Chunsheng Feng et al.   NEUROPHARMACOLOGY

Disruption of pupil size modulation correlates with voluntary motor preparation deficits in Parkinson's disease

(2016) Chin-An Wang et al.   NEUROPSYCHOLOGIA

Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807

(2016) Lieven Declercq et al.   Molecular Imaging

An autoradiographic evaluation of AV-1451 Tau PET in dementia

(2016) Val J. Lowe et al.   Acta Neuropathologica Communications

Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory

(2015) Mara Mather et al.   BEHAVIORAL AND BRAIN SCIENCES

Resting-State Functional Connectivity of the Locus Coeruleus in Humans: In Comparison with the Ventral Tegmental Area/Substantia Nigra Pars Compacta and the Effects of Age

(2015) Sheng Zhang et al.   CEREBRAL CORTEX

On the relation between self-reported cognitive fatigue and the posterior hypothalamic−brainstem network

(2015) K. Hanken et al.   EUROPEAN JOURNAL OF NEUROLOGY

[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease

(2015) Ryuichi Harada et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Evidence for early and progressive ultrasonic vocalization and oromotor deficits in aPINK1gene knockout rat model of Parkinson's disease

(2015) Laura M. Grant et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia

(2015) Heidi I.L. Jacobs et al.   NEUROBIOLOGY OF AGING

CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety

(2015) Jordan G. McCall et al.   NEURON

Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson’s disease model

(2015) K. Hikishima et al.   NEUROSCIENCE

Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease

(2015) Robert H. Pietrzak et al.   JAMA Psychiatry

In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease

(2014) Victor L. Villemagne et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Test–retest reliability of 11C-ORM-13070 in PET imaging of α2C-adrenoceptors in vivo in the human brain

(2014) Jussi Lehto et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: High-resolution fast spin-echo T1-weighted imaging

(2014) Junko Takahashi et al.   Geriatrics & Gerontology International

Pupil diameter covaries with BOLD activity in human locus coeruleus

(2014) Peter R. Murphy et al.   HUMAN BRAIN MAPPING

A study of structural and functional connectivity in early Alzheimer's disease using rest fMRI and diffusion tensor imaging

(2014) R. Balachandar et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis

(2014) Joanes Grandjean et al.   JOURNAL OF NEUROSCIENCE

Pupil size signals mental effort deployed during multiple object tracking and predicts brain activity in the dorsal attention network and the locus coeruleus

(2014) D. Alnaes et al.   JOURNAL OF VISION

Differentiation of early-stage parkinsonisms using neuromelanin-sensitive magnetic resonance imaging

(2014) Chigumi Ohtsuka et al.   PARKINSONISM & RELATED DISORDERS

Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices

(2014) D. J. Chandler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designer receptor manipulations reveal a role of the locus coeruleus noradrenergic system in isoflurane general anesthesia

(2014) E. M. Vazey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

(2013) Chun-Fang Xia et al.   Alzheimers & Dementia

Neuromelanin Magnetic Resonance Imaging in Parkinson's Disease and Multiple System Atrophy

(2013) Keita Matsuura et al.   EUROPEAN NEUROLOGY

β2Adrenergic Receptor, Protein Kinase A (PKA) and c-Jun N-terminal Kinase (JNK) Signaling Pathways Mediate Tau Pathology in Alzheimer Disease Models

(2013) Dayong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A , and Frank Neuronal Loss

(2013) R. M. Cohen et al.   JOURNAL OF NEUROSCIENCE

Reduced functional connectivity in early-stage drug-naive Parkinson's disease: a resting-state fMRI study

(2013) ChunYan Luo et al.   NEUROBIOLOGY OF AGING

Infraslow LFP correlates to resting-state fMRI BOLD signals

(2013) Wen-Ju Pan et al.   NEUROIMAGE

Neural reserve, neuronal density in the locus ceruleus, and cognitive decline

(2013) R. S. Wilson et al.   NEUROLOGY

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Changes in substantia nigra and locus coeruleus in patients with early-stage Parkinson's disease using neuromelanin-sensitive MR imaging

(2013) Chigumi Ohtsuka et al.   NEUROSCIENCE LETTERS

Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

A hitchhiker's guide to diffusion tensor imaging

(2013) José M. Soares et al.   Frontiers in Neuroscience

Heavy metals in locus ceruleus and motor neurons in motor neuron disease

(2013) Roger Pamphlett et al.   Acta Neuropathologica Communications

Decreased carbon-11-flumazenil binding in early Alzheimer’s disease

(2012) Belen Pascual et al.   BRAIN

Resting state functional connectivity of the striatum in Parkinson’s disease

(2012) Carl D. Hacker et al.   BRAIN

The Locus Coeruleus-Norepinephrine Network Optimizes Coupling of Cerebral Blood Volume with Oxygen Demand

(2012) Lane K Bekar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia

(2012) K. Del Tredici et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A noradrenergic theory of cognitive reserve: implications for Alzheimer's disease

(2012) Ian H. Robertson   NEUROBIOLOGY OF AGING

NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain

(2012) Hui Zhang et al.   NEUROIMAGE

Orienting and Reorienting: The Locus Coeruleus Mediates Cognition through Arousal

(2012) Susan J. Sara et al.   NEURON

The pattern of attentional deficits in Parkinson's disease

(2012) Kathy Dujardin et al.   PARKINSONISM & RELATED DISORDERS

Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation

(2012) Yuanlin Dong et al.   PLoS One

Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease

(2012) Yunqi Xu et al.   PROGRESS IN NEUROBIOLOGY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons

(2011) Andre L. Curtis et al.   NEUROPHARMACOLOGY

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

(2010) Jin Hyung Lee et al.   NATURE

The norepinephrine transporter (NET) radioligand (S,S)-[18F]FMeNER-D2 shows significant decreases in NET density in the human brain in Alzheimer's disease: A post-mortem autoradiographic study

(2010) Balázs Gulyás et al.   NEUROCHEMISTRY INTERNATIONAL

Dementia with Lewy bodies and Alzheimer disease: Neurodegenerative patterns characterized by DTI

(2010) K. Kantarci et al.   NEUROLOGY

Axial diffusivity is increased in the degenerating superior cerebellar peduncles of Friedreich's ataxia

(2010) Riccardo Della Nave et al.   NEURORADIOLOGY

Simultaneous fMRI and Electrophysiology in the Rodent Brain

(2010) Wen-ju Pan et al.   Jove-Journal of Visualized Experiments

Brainstem pathology and non-motor symptoms in PD

(2009) Lea Tenenholz Grinberg et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

In vivo mapping of the human locus coeruleus

(2009) Noam I. Keren et al.   NEUROIMAGE

Use of Neuromelanin-Sensitive MRI to Distinguish Schizophrenic and Depressive Patients and Healthy Individuals Based on Signal Alterations in the Substantia Nigra and Locus Ceruleus

(2008) Eri Shibata et al.   BIOLOGICAL PSYCHIATRY

Norepinephrinergic afferents and cytology of the macaque monkey midline, mediodorsal, and intralaminar thalamic nuclei

(2008) Brent A. Vogt et al.   Brain Structure & Function

Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest

(2008) Amir Shmuel et al.   HUMAN BRAIN MAPPING

Diffusion tensor imaging of the cortico-ponto-cerebellar pathway in patients with adult-onset ataxic neurodegenerative disease

(2008) Kaeko Kitamura et al.   NEURORADIOLOGY

Modafinil Shifts Human Locus Coeruleus to Low-Tonic, High-Phasic Activity During Functional MRI

(2008) M. J. Minzenberg et al.   SCIENCE