Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis

MCH Neurons Regulate Permeability of the Median Eminence Barrier

(2020) Hong Jiang et al.   NEURON

NF-κB signaling in tanycytes mediates inflammation-induced anorexia

(2020) Mareike Böttcher et al.   Molecular Metabolism

Exciting advances in GPCR-based drugs discovery for treating metabolic disease and future perspectives

(2019) Mar Quiñones et al.   Expert Opinion on Drug Discovery

Dynamic Network Activation of Hypothalamic MCH Neurons in REM Sleep and Exploratory Behavior

(2019) Carlos Blanco-Centurion et al.   JOURNAL OF NEUROSCIENCE

Ghrelin and food reward

(2019) Omar Al Massadi et al.   NEUROPHARMACOLOGY

MCH neuron dependent reward and feeding

(2019) Pelin Dilsiz et al.   NEUROENDOCRINOLOGY

MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity and Glucose Intolerance

(2019) Omar Al-Massadi et al.   DIABETES

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories

(2019) Shuntaro Izawa et al.   SCIENCE

Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity

(2019) Melissa J. Chee et al.   Molecular Metabolism

Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone

(2018) Emily E. Noble et al.   Cell Metabolism

The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism

(2018) Vincent Prevot et al.   ENDOCRINE REVIEWS

Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake

(2018) Amparo Romero-Picó et al.   NEUROPHARMACOLOGY

Ghrelin and LEAP-2: Rivals in Energy Metabolism

(2018) Omar Al-Massadi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons

(2018) Marc Schneeberger et al.   Molecular Metabolism

A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models

(2017) Yayoi Kawata et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Presynaptic Regulation of Leptin in a Defined Lateral Hypothalamus–Ventral Tegmental Area Neurocircuitry Depends on Energy State

(2017) Jing-Jing Liu et al.   JOURNAL OF NEUROSCIENCE

The cellular and molecular bases of leptin and ghrelin resistance in obesity

(2017) Huxing Cui et al.   Nature Reviews Endocrinology

Current Understanding of the Hypothalamic Ghrelin Pathways Inducing Appetite and Adiposity

(2017) Omar Al Massadi et al.   TRENDS IN NEUROSCIENCES

Evolution of physicochemical properties of melanin concentrating hormone receptor 1 (MCHr1) antagonists

(2016) Anders Johansson   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs

(2016) Karolina Ploj et al.   BRITISH JOURNAL OF PHARMACOLOGY

Unimolecular Polypharmacy for Treatment of Diabetes and Obesity

(2016) Matthias H. Tschöp et al.   Cell Metabolism

Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation

(2016) Ophélia Le Thuc et al.   EMBO REPORTS

Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress

(2016) Monica Imbernon et al.   HEPATOLOGY

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

(2016) Alessia Ligresti et al.   PHYSIOLOGICAL REVIEWS

Cilia-based flow network in the brain ventricles

(2016) R. Faubel et al.   SCIENCE

Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks

(2016) J. Antonio González et al.   Nature Communications

Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity

(2016) A. Christine Hausen et al.   Cell Reports

Physical Exercise Counteracts Stress-induced Upregulation of Melanin-concentrating Hormone in the Brain and Stress-induced Persisting Anxiety-like Behaviors

(2016) Tae-Kyung Kim et al.   Experimental Neurobiology

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

Melanin-concentrating hormone is necessary for olanzapine-inhibited locomotor activity in male mice

(2015) Melissa J.S. Chee et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Optogenetic Evidence for Inhibitory Signaling from Orexin to MCH Neurons via Local Microcircuits

(2015) J. Apergis-Schoute et al.   JOURNAL OF NEUROSCIENCE

Melanin-Concentrating Hormone Neurons Release Glutamate for Feedforward Inhibition of the Lateral Septum

(2015) M. J. S. Chee et al.   JOURNAL OF NEUROSCIENCE

Antidepressant effects of exercise are produced via suppression of hypocretin/orexin and melanin-concentrating hormone in the basolateral amygdala

(2015) Tae-Kyung Kim et al.   NEUROBIOLOGY OF DISEASE

Deletion of Melanin Concentrating Hormone Receptor-1 disrupts overeating in the presence of food cues

(2015) Andrew Sherwood et al.   PHYSIOLOGY & BEHAVIOR

Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance

(2015) Mar Quiñones et al.   Molecular Metabolism

Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression

(2015) Aurélie Delacrétaz et al.   PLoS One

Leptin Acts via Lateral Hypothalamic Area Neurotensin Neurons to Inhibit Orexin Neurons by Multiple GABA-Independent Mechanisms

(2014) P. B. Goforth et al.   JOURNAL OF NEUROSCIENCE

Connecting metabolism and reproduction: Roles of central energy sensors and key molecular mediators

(2014) Juan Roa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

(2014) Ana I Domingos et al.   eLife

Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action

(2013) Amanda Laque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Expression of Melanin-Concentrating Hormone Receptor 2 Protects Against Diet-Induced Obesity in Male Mice

(2013) Melissa J. S. Chee et al.   ENDOCRINOLOGY

Ablation of Neurons Expressing Melanin-Concentrating Hormone (MCH) in Adult Mice Improves Glucose Tolerance Independent of MCH Signaling

(2013) B. B. Whiddon et al.   JOURNAL OF NEUROSCIENCE

Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus

(2013) Sonia Jego et al.   NATURE NEUROSCIENCE

Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

(2013) Grégory Conductier et al.   NATURE NEUROSCIENCE

MCH Neurons Are the Primary Sleep-Promoting Group

(2013) Dheeraj Pelluru et al.   SLEEP

Energy balance regulation by thyroid hormones at central level

(2013) Miguel López et al.   TRENDS IN MOLECULAR MEDICINE

The Role of Melanin-Concentrating Hormone and Its Receptors in Energy Homeostasis

(2013) Douglas J. MacNeil   Frontiers in Endocrinology

Control of Ventricular Ciliary Beating by the Melanin Concentrating Hormone-Expressing Neurons of the Lateral Hypothalamus: A Functional Imaging Survey

(2013) Grégory Conductier et al.   Frontiers in Endocrinology

Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons

(2012) Yang Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Central Melanin-Concentrating Hormone Influences Liver and Adipose Metabolism Via Specific Hypothalamic Nuclei and Efferent Autonomic/JNK1 Pathways

(2012) Monica Imbernon et al.   GASTROENTEROLOGY

Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-induced obese mice

(2012) A N A Verty et al.   INTERNATIONAL JOURNAL OF OBESITY

Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus

(2012) Melissa J.S. Chee et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Thyrotropin-Releasing Hormone (TRH) Inhibits Melanin-Concentrating Hormone Neurons: Implications for TRH-Mediated Anorexic and Arousal Actions

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Central nervous system control of metabolism

(2012) Martin G. Myers et al.   NATURE

Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: Reduced appetite for calories and suppression of addictive-like behaviors

(2012) Camilla Karlsson et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility

(2012) Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arcuate AgRP neurons and the regulation of energy balance

(2012) Céline Cansell et al.   Frontiers in Endocrinology

Involvement of the opioid system in the orexigenic and hedonic effects of melanin-concentrating hormone

(2011) Carlos Andres Lopez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance

(2011) Gina M. Leinninger et al.   Cell Metabolism

The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior

(2011) M.J. García-Fuster et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Anatomical organization of the melanin-concentrating hormone peptide family in the mammalian brain

(2011) Jackson C. Bittencourt   GENERAL AND COMPARATIVE ENDOCRINOLOGY

CNS leptin and insulin action in the control of energy homeostasis

(2010) Bengt F. Belgardt et al.   Annals of the New York Academy of Sciences

Glucose Stimulation of Hypothalamic MCH Neurons Involves KATP Channels, Is Modulated by UCP2, and Regulates Peripheral Glucose Homeostasis

(2010) Dong Kong et al.   Cell Metabolism

The Endogenous Actions of Hypothalamic Peptides on Brown Adipose Tissue Thermogenesis in the Rat

(2010) Aaron N. A. Verty et al.   ENDOCRINOLOGY

You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice

(2010) Yan Wang et al.   GUT

Caloric Restriction Experience Reprograms Stress and Orexigenic Pathways and Promotes Binge Eating

(2010) D. E. Pankevich et al.   JOURNAL OF NEUROSCIENCE

Two Naturally Occurring Mutations in the Type 1 Melanin-Concentrating Hormone Receptor Abolish Agonist-Induced Signaling

(2010) C. Goldstein et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Increased orexin and melanin-concentrating hormone expression in the perifornical lateral hypothalamus of rats prone to overconsuming a fat-rich diet

(2010) Irene Morganstern et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effects of intracerebroventricular and intra-accumbens melanin-concentrating hormone agonism on food intake and energy expenditure

(2009) Benjamin Guesdon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Involvement of hypothalamic peptides in the anorectic action of the CB1receptor antagonist rimonabant (SR 141716)

(2009) Aaron N. A. Verty et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice

(2009) Masahiko Ito et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enhanced Excitatory Input to Melanin Concentrating Hormone Neurons during Developmental Period of High Food Intake Is Mediated by GABA

(2009) Y. Li et al.   JOURNAL OF NEUROSCIENCE

Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle

(2009) O. K. Hassani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats

(2009) Sunila G. Nair et al.   PSYCHOPHARMACOLOGY

Dysregulation of the Mesolimbic Dopamine System and Reward in MCH−/− Mice

(2008) Pavlos Pissios et al.   BIOLOGICAL PSYCHIATRY

Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression

(2008) J.T. Willie et al.   NEUROSCIENCE

The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

(2007) Jessica Santollo et al.   PHYSIOLOGY & BEHAVIOR