Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties

Structural equilibrium underlying ligand-dependent activation of β2-adrenoreceptor

(2020) Shunsuke Imai et al.   Nature Chemical Biology

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

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Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane

(2020) Jie Yin et al.   NATURE

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

(2020) Kuglae Kim et al.   CELL

Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine

(2019) Kanako Terakado Kimura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology

(2019) Stephen J. Kaar et al.   NEUROPHARMACOLOGY

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

(2019) Carmen Klein Herenbrink et al.   ACS Chemical Biology

KAMO: towards automated data processing for microcrystals

(2018) Keitaro Yamashita et al.   Acta Crystallographica Section D-Structural Biology

Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

(2018) Sheng Wang et al.   NATURE

Aminergic GPCR–Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data

(2018) Márton Vass et al.   JOURNAL OF MEDICINAL CHEMISTRY

Serotonin and brain function: a tale of two receptors

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Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

(2017) John D McCorvy et al.   Nature Chemical Biology

The influence of the glutamatergic system on cognition in schizophrenia: A systematic review

(2017) Elizabeth H.X. Thomas et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists

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PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

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Effects of ziprasidone, SCH23390 and SB277011 on spatial memory in the Morris water maze test in naive and MK-801 treated mice

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PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

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Novel Aza-analogous Ergoline Derived Scaffolds as Potent Serotonin 5-HT6 and Dopamine D2 Receptor Ligands.

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Clozapine, a Fast-Off-D2 Antipsychotic

(2013) Philip Seeman   ACS Chemical Neuroscience

Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography

(2013) James Foadi et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

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Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis

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Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Structure–Functional Selectivity Relationship Studies of β-Arrestin-Biased Dopamine D2 Receptor Agonists

(2012) Xin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Automated design of ligands to polypharmacological profiles

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Serotonin 2A receptor antagonists for treatment of schizophrenia

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Discovery of  -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

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Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Partial agonists in schizophrenia – why some work and others do not: insights from preclinical animal models

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Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist-Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile

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Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism

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Crystallizing membrane proteins using lipidic mesophases

(2009) Martin Caffrey et al.   Nature Protocols