Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

Enhanced Dopamine Release by Dopamine Transport Inhibitors Described by a Restricted Diffusion Model and Fast-Scan Cyclic Voltammetry

(2016) Alexander F. Hoffman et al.   ACS Chemical Neuroscience

Biased agonism: An emerging paradigm in GPCR drug discovery

(2016) Zoran Rankovic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System

(2016) Anushree N Karkhanis et al.   NEUROPSYCHOPHARMACOLOGY

Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias

(2015) Kimberly M. Lovell et al.   ACS Chemical Neuroscience

New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling

(2015) Tarsis F. Brust et al.   BIOCHEMICAL PHARMACOLOGY

Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens

(2015) Jamie H. Rose et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting

(2015) Lei Zhou et al.   NEUROPHARMACOLOGY

Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus

(2015) Jenny Morgenweck et al.   NEUROPHARMACOLOGY

Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment

(2015) Nicole A. Crowley et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Social Isolation Rearing Increases Nucleus Accumbens Dopamine and Norepinephrine Responses to Acute Ethanol in Adulthood

(2014) Anushree N. Karkhanis et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

(2014) Adam P. Kardon et al.   NEURON

Does the kappa opioid receptor system contribute to pain aversion?

(2014) Catherine M. Cahill et al.   Frontiers in Pharmacology

Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors

(2013) Lei Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations

(2012) Erin S. Calipari et al.   ADDICTION BIOLOGY

Galanin-Expression and Galanin-Dependent Sensory Neurons Are Not Required for Itch

(2012) Fiona E Holmes et al.   Molecular Pain

Opioid Facilitation of Rewarding Electrical Brain Stimulation Is Suppressed in Rats with Neuropathic Pain

(2011) Eric E. Ewan et al.   ANESTHESIOLOGY

Demon Voltammetry and Analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures

(2011) Jordan T. Yorgason et al.   JOURNAL OF NEUROSCIENCE METHODS

Regulation of  -Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo

(2011) K. A. Berg et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Therapeutic Potential of κ-Opioids for Treatment of Pain and Addiction

(2010) Charles Chavkin   NEUROPSYCHOPHARMACOLOGY

Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats

(2010) S. Stevens Negus et al.   PSYCHOPHARMACOLOGY

Kappa opioids and the modulation of pain

(2010) Bronwyn Kivell et al.   PSYCHOPHARMACOLOGY

Dynorphin, stress, and depression

(2009) Allison T. Knoll et al.   BRAIN RESEARCH

kappa-Opioid receptor signaling and brain reward function

(2009) Adrie W. Bruijnzeel   BRAIN RESEARCH REVIEWS

Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study

(2009) H. Kumagai et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking

(2009) Benjamin B. Land et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prodynorphin-Derived Peptides Are Critical Modulators of Anxiety and Regulate Neurochemistry and Corticosterone

(2008) Walter Wittmann et al.   NEUROPSYCHOPHARMACOLOGY