RNA cancer nanomedicine: nanotechnology-mediated RNA therapy

Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages

(2022) Xiangang Huang et al.   Nature Protocols

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Intercalation-Driven Formation of siRNA Nanogels for Cancer Therapy

(2021) Xiangang Huang et al.   NANO LETTERS

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

(2021) Wei Chen et al.   Nature Reviews Cardiology

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Surface-Functionalized PEGylated Nanoparticles Deliver Messenger RNA to Pulmonary Immune Cells

(2020) Xiyu Ke et al.   ACS Applied Materials & Interfaces

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

(2020) Wei Tao et al.   Science Translational Medicine

Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

(2020) Tuo Wei et al.   Nature Communications

Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

(2020) Mohammad Ariful Islam et al.   BIOMATERIALS

Nanomachines and Other Caps on Mesoporous Silica Nanoparticles for Drug Delivery

(2019) Wei Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor growth in patient-derived xenografts lung cancer models

(2019) Massimo Moro et al.   JOURNAL OF CONTROLLED RELEASE

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

(2019) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Intranasal delivery of targeted polyfunctional gold–iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide

(2019) Uday K. Sukumar et al.   BIOMATERIALS

NanoRNP Overcomes Tumor Heterogeneity in Cancer Treatment

(2019) Qi Liu et al.   NANO LETTERS

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

(2019) Na Kong et al.   Science Translational Medicine

Size/Charge Changeable Acidity-Responsive Micelleplex for Photodynamic-Improved PD-L1 Immunotherapy with Enhanced Tumor Penetration

(2018) Liangliang Dai et al.   ADVANCED FUNCTIONAL MATERIALS

Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment

(2018) Chenmeng Qiao et al.   ADVANCED MATERIALS

Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer

(2018) Sophia A. Shahin et al.   Nanomedicine-Nanotechnology Biology and Medicine

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

Biomedical applications of mRNA nanomedicine

(2018) Qingqing Xiong et al.   Nano Research

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

(2018) Mohammad Ariful Islam et al.   Nature Biomedical Engineering

Tumor Cell-Derived Extracellular Vesicle-Coated Nanocarriers: An Efficient Theranostic Platform for the Cancer-Specific Delivery of Anti-miR-21 and Imaging Agents

(2018) Rajendran JC Bose et al.   ACS Nano

Stearyl polyethylenimine complexed with plasmids as the core of human serum albumin nanoparticles noncovalently bound to CRISPR/Cas9 plasmids or siRNA for disrupting or silencing PD-L1 expression for immunotherapy

(2018) Wei-Jie Cheng et al.   International Journal of Nanomedicine

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA

(2017) Rein Verbeke et al.   JOURNAL OF CONTROLLED RELEASE

Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy

(2017) Xiaoding Xu et al.   NANO LETTERS

Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs

(2016) Sayan Mullick Chowdhury et al.   JOURNAL OF CONTROLLED RELEASE

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Polymer Nanoparticles Mediated Codelivery of AntimiR-10b and AntimiR-21 for Achieving Triple Negative Breast Cancer Therapy

(2015) Rammohan Devulapally et al.   ACS Nano

Nanoparticle-Delivered Antisense MicroRNA-21 Enhances the Effects of Temozolomide on Glioblastoma Cells

(2015) Jeyarama S. Ananta et al.   MOLECULAR PHARMACEUTICS

Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment

(2015) João Conde et al.   NATURE MATERIALS

siRNA Versus miRNA as Therapeutics for Gene Silencing

(2015) Jenny K W Lam et al.   Molecular Therapy-Nucleic Acids

Nanoparticle-Delivered Transforming Growth Factor-β siRNA Enhances Vaccination against Advanced Melanoma by Modifying Tumor Microenvironment

(2014) Zhenghong Xu et al.   ACS Nano

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients

(2011) T. L. Lotan et al.   CLINICAL CANCER RESEARCH

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Is PTEN loss associated with clinical outcome measures in human prostate cancer?

(2008) P McCall et al.   BRITISH JOURNAL OF CANCER