Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile

Valproic acid and epilepsy: from molecular mechanisms to clinical evidences

(2018) Michele Romoli et al.   Current Neuropharmacology

sec -Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain

(2017) Dan Kaufmann et al.   PHARMACOLOGICAL RESEARCH

Epigenetic Downregulation of Scn3a Expression by Valproate: a Possible Role in Its Anticonvulsant Activity

(2016) Na-Na Tan et al.   MOLECULAR NEUROBIOLOGY

Comparative teratogenicity analysis of valnoctamide, risperidone, and olanzapine in mice

(2015) Bogdan J Wlodarczyk et al.   BIPOLAR DISORDERS

The potential of sec -butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus

(2015) Tawfeeq Shekh-Ahmad et al.   EPILEPSY & BEHAVIOR

Pharmacodynamic and pharmacokinetic analysis of CNS-active constitutional isomers of valnoctamide and sec-butylpropylacetamide — Amide derivatives of valproic acid

(2015) Hafiz Mawasi et al.   EPILEPSY & BEHAVIOR

The use of valproic acid and multiple sclerosis

(2014) Nete Munk Nielsen et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats

(2013) Pavel Mareš et al.   EPILEPSY RESEARCH

Stereoselective Pharmacodynamic and Pharmacokinetic Analysis of sec-Butylpropylacetamide (SPD), a New CNS-Active Derivative of Valproic Acid with Unique Activity against Status Epilepticus

(2013) Naama Hen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Valproic acid pathway

(2013) Yogita Ghodke-Puranik et al.   Pharmacogenetics and Genomics

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

QSPR Study of Valproic Acid and Its Functionalized Derivatives

(2012) Nieves C. Comelli et al.   Molecular Informatics

A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus

(2012) W. Pouliot et al.   NEUROSCIENCE

Exposure to Valproic Acid Inhibits Chondrogenesis and Osteogenesis in Mid-Organogenesis Mouse Limbs

(2012) France-Hélène Paradis et al.   TOXICOLOGICAL SCIENCES

A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage

(2011) H. Steve White et al.   EPILEPSIA

Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium

(2011) N. Terbach et al.   JOURNAL OF CELL SCIENCE

The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients

(2010) Lan Tan et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Progress report on new antiepileptic drugs: A summary of the Tenth Eilat Conference (EILAT X)

(2010) Meir Bialer et al.   EPILEPSY RESEARCH

Evaluation of the antiallodynic, teratogenic and pharmacokinetic profile of stereoisomers of valnoctamide, an amide derivative of a chiral isomer of valproic acid

(2010) Dan Kaufmann et al.   NEUROPHARMACOLOGY

The relationship between glucuronide conjugate levels and hepatotoxicity after oral administration of valproic acid

(2009) Min Sun Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

α-Fluoro-2,2,3,3-Tetramethylcyclopropanecarboxamide, a Novel Potent Anticonvulsant Derivative of a Cyclic Analogue of Valproic Acid

(2009) Neta Pessah et al.   JOURNAL OF MEDICINAL CHEMISTRY

Key factors in the discovery and development of new antiepileptic drugs

(2009) Meir Bialer et al.   NATURE REVIEWS DRUG DISCOVERY

Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: Evaluation of the teratogenic effects of its amide derivatives in NMRI mice

(2008) Akinobu Okada et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10

(2008) U. A. Argikar et al.   DRUG METABOLISM AND DISPOSITION

Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX)

(2008) Meir Bialer et al.   EPILEPSY RESEARCH

Hydroxamic acid and fluorinated derivatives of valproic acid: Anticonvulsant activity, neurotoxicity and teratogenicity

(2008) Ute Gravemann et al.   NEUROTOXICOLOGY AND TERATOLOGY