Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Oncology
Anna Wawruszak, Marta Halasa, Estera Okon, Wirginia Kukula-Koch, Andrzej Stepulak
Summary: Breast cancer is the most common malignancy affecting women worldwide, with valproic acid showing promising potential in inhibiting cancer cell proliferation. Studies have demonstrated that VPA, a member of the group of histone deacetylase inhibitors, can modulate multiple signaling pathways and improve the effectiveness of current treatment methods for breast cancer.
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Review
Pharmacology & Pharmacy
Bertram Pitt, Nadia R. Sutton, Zhong Wang, Sascha N. Goonewardena, Michael Holinstat
Summary: Valproic acid is considered a potential therapeutic for COVID-19 due to its ability to impact viral entry into cells and modulate immune and cytokine responses. Its combined anti-thrombotic, anti-platelet, and anti-inflammatory effects suggest it could be a promising treatment target.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Agricultural Engineering
Xuefeng Lu, Tae Kyung Hyun
Summary: Post-translational histone modifications, such as histone acetylation, play key roles in regulating gene expression in plant growth, development, and stress responses. The research found that HDAC inhibitors led to hyperacetylation of histone H3, enhancing MeJA-induced ginsenoside production in ginseng adventitious roots. Additionally, the study identified specific PgHDACs that may serve as crucial factors in controlling MeJA-induced ginsenoside production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Nur Selvi Gunel, Nihal Birden, Cansu Caliskan Kurt, Bakiye Goker Bagca, Behrouz Shademan, Fatma Sogutlu, Neslihan Pinar Ozates, Cigir Biray Avci
Summary: Valproic acid (VPA) can adjust gene expression patterns in thyroid cancer cells, including microRNAs (miRNAs), by targeting histone deacetylase (HDAC). The expression of oncogenic genes decreased while tumor inhibitory genes expression increased significantly in cells treated with VPA.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Oncology
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Summary: Our understanding of the identity of many cancers has greatly increased in recent years, leading to progress in early detection and treatment options. However, gastric cancer remains poorly treated with low survival rates. The lack of possibilities for early detection and the variations between tumors of gastric cancer patients are major challenges. Histone Deacetylases (HDACs) have been identified to be potentially related to gastric cancer. In this review, we summarize the current knowledge on the role of HDACs in gastric cancer development and their potential as early detection markers and targets for new treatment options.
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Robert Jenke, Nina Ressing, Finn K. Hansen, Achim Aigner, Thomas Buch
Summary: Epigenetic changes can drive cancer malignancy, while histone deacetylase inhibitors (HDACis) hold promise as anticancer drugs due to their ability to target multiple pathways relevant to the disease.
Article
Biochemical Research Methods
Kavinda E. Herath, Ishadi K. M. Kodikara, Mary Kay H. Pflum
Summary: HDAC1 plays a key role in diverse cellular processes and its aberrant expression is linked to many diseases. Nonhistone substrates of HDAC1 have been discovered, revealing its diverse roles beyond epigenetics. We tested the robustness of HDAC1 substrate trapping with multiple mutants and found that using a single mutant yielded more biologically interesting hits. Carnosine N-methyltransferase 1 (CARNMT1) was validated as an HDAC1 substrate. Mutant trapping is an effective method for discovering unanticipated HDAC substrates and linking HDAC activity to unexpected biological functions.
JOURNAL OF PROTEOMICS
(2023)
Article
Oncology
Hao Wang, Lei Shi, Zhimin Wang
Summary: The research demonstrated that the structurally modified DMC-HA effectively inhibited human glioblastoma U87 cells, induced apoptosis, and increased histone H3 acetylation levels. Pharmacokinetic studies indicated acceptable pharmacokinetic properties for DMC-HA in vivo, suggesting its potential for further development as a chemotherapeutic drug.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Seiichi Okabe, Yuko Tanaka, Akihiko Gotoh
Summary: The study demonstrated that the dual inhibitor CUDC-907 targeting PI3K and HDAC could effectively suppress myeloma cells by inhibiting HDAC activity and reducing the expression of key proteins involved in cancer cell survival. Combination treatment of myeloma cells with CUDC-907 and carfilzomib showed increased cytotoxicity, indicating a potential strategy to enhance the effects of proteasome inhibitors against MM cells.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Ana C. R. Ribeiro, Fay M. Jahr, Elisa Hawkins, Mohamad M. Kronfol, Rabha M. Younis, Joseph L. McClay, Laxmikant S. Deshpande
Summary: Exposure to organophosphate compounds in rats led to an increase in HDAC protein expression and enzyme activity in the hippocampus, as well as a decrease in H3K9ac and BDNF protein levels. Treatment with an HDAC inhibitor showed promising results in reducing immobility time in the Forced Swim Test for rats exposed to organophosphates, suggesting potential new targets for the treatment of GWI symptoms.
Article
Biochemistry & Molecular Biology
Luna-Palencia Gabriela Rebeca, Correa-Basurto Jose, Trujillo-Ferrara Jose, Meraz-Rios Marco Antonio, Vasquez-Moctezuma Ismael
Summary: The study revealed that o-OH-VPA effectively inhibited the survival of HeLa cells and increased cell doubling time without exhibiting toxicity toward normal cells. o-OH-VPA acted as an HDACI in HeLa cells, affecting p21 expression and caspase-3 activity to arrest the cell cycle.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Oncology
Phaedon D. Zavras, Aditi Shastri, Mendel Goldfinger, Amit K. Verma, Yogen Saunthararajah
Summary: The success of hypomethylating agents in myelodysplastic syndromes and acute myelogenous leukemias lies in their ability to selectively target DNA methyltransferase 1 (DNMT1) during the S-phase. Lessons learned from clinical trials suggest that dose and schedule selection are crucial for maintaining clinical response while avoiding detrimental effects on bone marrow reserves. Combination therapy with investigational agents should focus on enhancing HMA activity through manipulations of pyrimidine metabolism and inhibition of epigenetic enzymes, while adhering to principles of therapeutic index and molecular targeting.
CLINICAL CANCER RESEARCH
(2021)
Editorial Material
Pediatrics
Paula L. Hedley, Marie Baekvad-Hansen, Gitte Hedermann, Henrik Hjalgrim, David M. Hougaard, Mads Melbye, Morten Breindahl, Lone Krebs, Anders Hviid, Ulrik Lausten-Thomsen, Michael Christiansen
Article
Clinical Neurology
Johanna Balslev Andersen, Finn Sellebjerg, Melinda Magyari
Summary: This study found no increased association of adverse pregnancy outcomes in newborns with fetal exposure to disease-modifying drugs (DMDs) when compared with either DMD-unexposed pregnancies or the general population.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Alessio Signori, Johannes Lorscheider, Sandra Vukusic, Maria Trojano, Pietro Iaffaldano, Jan Hillert, Robert Hyde, Fabio Pellegrini, Melinda Magyari, Nils Koch-Henriksen, Per Soelberg Sorensen, Tim Spelman, Anneke van Der Walt, Dana Horakova, Eva Havrdova, Marc Girard, Sara Eichau, Francois Grand'Maison, Oliver Gerlach, Murat Terzi, Serkan Ozakbas, Olga Skibina, Vincent Van Pesch, Maria Jose Sa, Julie Prevost, Raed Alroughani, Pamela A. McCombe, Riadh Gouider, Saloua Mrabet, Tamara Castillo-Trivino, Chao Zhu, Koen de Gans, Jose Luis Sanchez-Menoyo, Bassem Yamout, Samia Khoury, Maria Pia Sormani, Tomas Kalincik, Helmut Butzkueven
Summary: This study identifies different subgroups of patients with secondary progressive multiple sclerosis (SPMS) based on their longitudinal trajectories of disability. The findings suggest that SPMS patients progress at greatly different rates and the identification of distinct trajectories can guide better patient selection in future clinical trials. Additionally, the distinct trajectories may reflect heterogeneous pathological mechanisms of progression.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Arvid Engstroem, Viktor Wintzell, Mads Melbye, Anders Hviid, Bjoern Eliasson, Soffia Gudbjoernsdottir, Kristian Hveem, Christian Jonasson, Henrik Svanstroem, Bjoern Pasternak, Peter Ueda
Summary: Using nationwide registers data from Denmark, Norway, and Sweden, this study demonstrates an association between the use of SGLT2 inhibitors and the risk of new-onset atrial fibrillation. Compared to GLP-1 receptor agonists, SGLT2 inhibitors are associated with a modestly reduced risk of new-onset atrial fibrillation.
Correction
Multidisciplinary Sciences
Nete Munk Nielsen, Thor Gronborg Junker, Sanne Grundvad Boelt, Arieh S. Cohen, Kassandra L. Munger, Egon Stenager, Alberto Ascherio, Lasse Boding, Anders Hviid
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Zsofia Kokas, Anett Jardanhazy, Daniel Sandi, Tamas Biernacki, Zsanett Fricska-Nagy, Judit Fuvesi, Halina Bartosik-Psujek, Vanja Basic Kes, Thomas Berger, Achim Berthele, Jelena Drulovic, Bernhard Hemmer, Dana Horakova, Alenka Horvat Ledinek, Eva Kubala Havrdova, Melinda Magyari, Konrad Rejdak, Cristina Tiu, Peter Turcani, Peter Klivenyi, Zsigmond Tamas Kincses, Laszlo Vecsei, Krisztina Bencsik
Summary: In most Central-Eastern European countries, the recommendations for multiple sclerosis (MS) care units are met, but there are still some deficiencies, such as the lack of speech therapists, specialists for continence, pain and spasticity, neuro-ophthalmologists, and otoneurologists. Although multiple disease-modifying therapies (DMTs) are reimbursed, not every center provides all available DMTs. Additionally, only Austria and the Czech Republic require national registry use. Therefore, in countries where MSCU recommendations are not fulfilled, a strictly regulated center system similar to the Austrian and Czech model, with a registry-based quality control, may ensure appropriate care for MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Obstetrics & Gynecology
Aya O. Nakitanda, Helle Kieler, Ingvild Odsbu, Samuel Rhedin, Catarina Almqvist, Bjorn Pasternak, Laura Pazzagli
Summary: Prenatal antibiotic use increases the risk of childhood infections in the first year of life, but is not associated with infant mortality due to infections. The association between prenatal antibiotic exposure and infant infections may be partly explained by shared familial factors and does not differ across different antibiotic classes.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Public, Environmental & Occupational Health
Peter Ueda, Bjorn Pasternak, Carl-Emil Lim, Martin Neovius, Manzur Kader, Magnus Forssblad, Jonas F. Ludvigsson, Henrik Svanstroem
Summary: A cohort study reveals that male football players in the Swedish top division have a significantly higher risk of neurodegenerative disease, especially Alzheimer's disease and other dementias. The study provides important data for assessing and managing risks in the sport.
LANCET PUBLIC HEALTH
(2023)
Letter
Medicine, General & Internal
Anders Hviid
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Clinical Neurology
Nils Iorgen Koch-Henriksen, Lau Caspar Thygesen, Per Soelberg Sorensen, Melinda Magyari
Summary: This study demonstrates the use of instrumental variables to reduce bias in observational studies and confirms the effectiveness of treatment in delaying disability in multiple sclerosis.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Chemistry, Analytical
Spyridon Kontaxis, Estela Laporta, Esther Garcia, Matteo Martinis, Letizia Leocani, Lucia Roselli, Mathias Due Buron, Ana Isabel Guerrero, Ana Zabala, Nicholas Cummins, Srinivasan Vairavan, Matthew Hotopf, Richard J. B. A. Dobson, Vaibhav Narayan, Maria Libera La Porta, Gloria Dalla Costa, Melinda Magyari, Per Soelberg Sorensen, Carlos Nos, Raquel Bailon, Giancarlo Comi, RADAR CNS Consortium
Summary: The aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). The study collected the 2MWDs as evaluated by clinicians and derived from accelerometer data from 154 pwMS, along with MS-related clinical outcomes. The results showed that estimating the 2MWD using a wearable device yielded a low error rate and had strong correlations with clinical outcomes.
Article
Medicine, General & Internal
Niklas Worm Andersson, Emilia Myrup Thiesson, Jorgen Vinslov Hansen, Anders Hviid
Summary: This study examined the risk of adverse events associated with the fourth dose of omicron adapted bivalent mRNA COVID-19 booster vaccines. It found that there was no significant increase in the rate of adverse events among adults aged 50 years or older.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Josefine Windfeld-Mathiasen, Henrik Horwitz, Johanna Balslev Andersen, Elisabeth Framke, Christina Gade, Jon Traerup Andersen, Melinda Magyari
Summary: This retrospective matched cohort study investigated the impact of exposure to interferon-beta during pregnancy on the risk of significant infections in early childhood. The study included 510 children born to mothers with multiple sclerosis who were exposed to interferon-beta in utero. The results showed that exposure to interferon-beta had little to no impact on the risk of acquiring significant infections during the first five years of childhood.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Dominika Stastna, Frederik Elberling, Luigi Pontieri, Elisabeth Framke, Dana Horakova, Jiri Drahota, Petra Nytrova, Melinda Magyari
Summary: This study evaluated the difference in relapse occurrence pre- and post-COVID-19 vaccination in Danish patients with relapsing multiple sclerosis. The findings showed that there was no significant increase in relapse activity following the administration of the first dose of the COVID-19 vaccine.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Richard Nicholas, Jeff Rodgers, James Witts, Annalaura Lerede, Tim Friede, Jan Hillert, Lars Forsberg, Anna Glaser, Ali Manouchehrinia, Ryan Ramanujam, Tim Spelman, Pernilla Klyve, Jiri Drahota, Dana Horakova, Hanna Joensen, Luigi Pontieri, Melinda Magyari, David Ellenberger, Alexander Stahmann, Helmut Butzkueven, Anneke Van der Walt, Vladimir Bezlyak, Carol Lines, Rod Middleton
Summary: This study analyzed registry data from multiple countries and found variations in DMT usage, with factors such as gender, disability level, and monitoring influencing the likelihood of receiving DMTs. The study also explored the impact of diagnosis on DMT usage in clinical SPMS.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)