Anticancer and Antibiotic Rhenium Tri- and Dicarbonyl Complexes: Current Research and Future Perspectives

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Therapeutic and Diagnostic Applications of Multimetallic Rhenium(I) Tricarbonyl Complexes

(2021) Zhouyang Huang et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Nanoparticles Functionalised with Re(I) Tricarbonyl Complexes for Cancer Theranostics

(2021) Marcus Mkhatshwa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA interaction, anticancer, antibacterial, ROS and lipid peroxidation studies of quinoxaline based organometallic Re(I) carbonyls

(2021) Reena R. Varma et al.   JOURNAL OF MOLECULAR STRUCTURE

Efficient Direct Nitrosylation of α-Diimine Rhenium Tricarbonyl Complexes to Structurally Nearly Identical Higher Charge Congeners Activable towards Photo-CO Release

(2021) Sara Nasiri Sovari et al.   MOLECULES

Photochemistry of Rhenium(I) Diimine Tricarbonyl Complexes in Biological Applications

(2021) Kevin Schindler et al.   CHIMIA

Combatting AMR: A molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

(2021) Sara Nasiri Sovari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Phosphorescent rhenium(I) complexes conjugated with artesunate: Mitochondrial targeting and apoptosis-ferroptosis dual induction

(2021) Rui-Rong Ye et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A New Model Applied for Evaluating a Rhenium-diselenium Drug: Breast Cancer Cells Stimulated by Cytokines Induced from Polynuclear Cells by LPS

(2020) VIJAY VEENA et al.   ANTICANCER RESEARCH

Luminescent Re(I)/Au(I) Species As Selective Anticancer Agents for HeLa Cells

(2020) Andrés Luengo et al.   INORGANIC CHEMISTRY

Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes

(2020) Joachim Delasoie et al.   Pharmaceutics

Recoding the Cancer Epigenome by Intervening in Metabolism and Iron Homeostasis with Mitochondria‐Targeted Rhenium(I) Complexes

(2020) Zheng‐Yin Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A bis‐chelating (O^N^O)/(N^N) ligand for the synthesis of heterobimetallic Pt(II)/Re(I) complexes: tools for the optimization of a new class of Pt(II) anticancer agents.

(2020) Bertrand Benoît et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exploring the In Vivo and In Vitro Anticancer Activity of Rhenium Isonitrile Complexes

(2020) Sierra C. Marker et al.   INORGANIC CHEMISTRY

Identification of novel potent and non-toxic anticancer, anti-angiogenic and antimetastatic rhenium complexes against colorectal carcinoma

(2020) Joachim Delasoie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aquation and Anation Kinetics of Rhenium(I) Dicarbonyl Complexes: Relation to Cell Toxicity and Bioavailability

(2020) Marietjie Schutte-Smith et al.   INORGANIC CHEMISTRY

Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy

(2020) Hui Shan Liew et al.   MOLECULES

Exploring rhenium (I) complexes as potential fluorophores for walled-cells (yeasts and bacteria): Photophysics, biocompatibility, and confocal microscopy

(2020) Alexander Carreño et al.   DYES AND PIGMENTS

Coordination Environment Prevents Access to Intraligand Charge-Transfer States through Remote Substitution in Rhenium(I) Terpyridinedicarbonyl Complexes

(2020) Ricardo J. Fernández-Terán et al.   INORGANIC CHEMISTRY

In-Depth Study of the Electronic Properties of NIR-Emissive κ3N Terpyridine Rhenium(I) Dicarbonyl Complexes

(2020) Thomas Auvray et al.   INORGANIC CHEMISTRY

Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling

(2020) Alice Domenichini et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The rhenium(I)-diselenoether anticancer drug targets ROS, TGF-β1, VEGF-A, and IGF-1 in an in vitro experimental model of triple-negative breast cancers

(2019) Philippe Collery et al.   INVESTIGATIONAL NEW DRUGS

First kinetic data of the CO substitution in fac-[Re(L,L′-Bid)(CO)3(X)] complexes (L,L′-Bid = acacetylacetonate or tropolonate) by tertiary phosphines PTA and PPh3: Synthesis and crystal structures of water-soluble rhenium(I) tri- and dicarbonyl complexes with 1,3,5-triaza-7-phosphaadamantane (PTA)

(2019) Amanda-Lee E. Manicum et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent

(2019) Chilaluck C. Konkankit et al.   INORGANIC CHEMISTRY

Mitochondria-Accumulating Rhenium(I) Tricarbonyl Complexes Induce Cell Death via Irreversible Oxidative Stress and Glutathione Metabolism Disturbance

(2019) Fang-Xin Wang et al.   ACS Applied Materials & Interfaces

Luminescent Rhenium(I) Polypyridine Complexes Appended with a Perylene Diimide or Benzoperylene Monoimide Moiety: Photophysics, Intracellular Sensing, and Photocytotoxic Activity

(2019) Alex Man-Hei Yip et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Rhenium Isonitrile Complex Induces Unfolded Protein Response‐Mediated Apoptosis in Cancer Cells

(2019) A. Paden King et al.   CHEMISTRY-A EUROPEAN JOURNAL

Electronic Communication in Luminescent Dicyanorhenate-Bridged Homotrinuclear Rhenium(I) Complexes

(2019) Yelan Xiao et al.   INORGANIC CHEMISTRY

Organometallic rhenium tricarbonyl–enrofloxacin and –levofloxacin complexes: synthesis, albumin-binding, DNA-interaction and cell viability studies

(2019) Chaido-Christina Pagoni et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

In Vivo Anticancer Activity of a Rhenium(I) Tricarbonyl Complex

(2019) Chilaluck C. Konkankit et al.   ACS Medicinal Chemistry Letters

Epidemiology and risk factors of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci infections in Zhejiang China from 2015 to 2017

(2019) Lin Huang et al.   Antimicrobial Resistance and Infection Control

A CuAAC Click Approach for the Introduction of Bidentate Metal Complexes to a Sulfanilamide-Derived Antibiotic Fragment

(2019) Reece G. Miller et al.   INORGANIC CHEMISTRY

Organometallic and coordination rhenium compounds and their potential in cancer therapy

(2019) Elisabeth B. Bauer et al.   COORDINATION CHEMISTRY REVIEWS

Design of Rhenium Compounds in Targeted Anticancer Therapeutics

(2019) Philippe Collery et al.   CURRENT PHARMACEUTICAL DESIGN

Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems

(2019) Joachim Delasoie et al.   Pharmaceutics

Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria

(2019) Angelo Frei et al.   CHEMISTRY-A EUROPEAN JOURNAL

Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate

(2018) Jing Yang et al.   BIOMATERIALS

Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium

(2018) Chilaluck C. Konkankit et al.   DALTON TRANSACTIONS

Ferrocifens labelled with an infrared rhenium tricarbonyl tag: synthesis, antiproliferative activity, quantification and nano IR mapping in cancer cells

(2018) Yong Wang et al.   DALTON TRANSACTIONS

Isomeric and hybrid ferrocenyl/cyrhetrenyl aldimines: a new family of multifunctional compounds

(2018) Juan Oyarzo et al.   DALTON TRANSACTIONS

The side effects of platinum-based chemotherapy drugs: a review for chemists

(2018) Rabbab Oun et al.   DALTON TRANSACTIONS

Bathochromic Shifts in Rhenium Carbonyl Dyes Induced through Destabilization of Occupied Orbitals

(2018) Daniel A. Kurtz et al.   INORGANIC CHEMISTRY

Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines

(2018) Sierra C. Marker et al.   INORGANIC CHEMISTRY

Dicarbonyl cis-[M(CO)2(N,O)(C)(P)] (M = Re, 99mTc) Complexes with a New [2 + 1 + 1] Donor Atom Combination

(2018) Charalampos Triantis et al.   INORGANIC CHEMISTRY

One-pot reaction of amide functionalized Re(I) based dinuclear metallacycles: Synthesis, characterization and evaluation for anticancer potential

(2018) R. Govindarajan et al.   POLYHEDRON

Resistance-breaking profiling and gene expression analysis on an organometallic ReI–phenanthridine complex reveal parallel activation of two apoptotic pathways

(2018) Marcel König et al.   MedChemComm

Slow-Targeted Release of a Ruthenium Anticancer Agent from Vitamin B12 Functionalized Marine Diatom Microalgae

(2018) Joachim Delasoie et al.   DALTON TRANSACTIONS

Influence of the substituent on the phosphine ligand in novel rhenium(i) aldehydes. Synthesis, computational studies and first insights into the antiproliferative activity

(2018) Michelle Muñoz-Osses et al.   DALTON TRANSACTIONS

Synthesis and antitumour evaluation of mono- and multinuclear [2+1] tricarbonylrhenium(I) complexes

(2018) Dylan Giffard et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cyclic voltammetry, relativistic DFT calculations and biological test of cytotoxicity in walled-cell models of two classical rhenium (I) tricarbonyl complexes with 5-amine-1,10-phenanthroline

(2018) Alexander Carreño et al.   CHEMICAL PHYSICS LETTERS

Synthesis of Re(I) Rings Comprising Different Re(I) Units and Their Light-Harvesting Abilities

(2018) Yasuomi Yamazaki et al.   INORGANIC CHEMISTRY

Exploring the cytotoxicity, uptake, cellular response, and proteomics of mono- and dinuclear DNA light-switch complexes

(2018) Paul James Jarman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioactive Heterobimetallic Re(I)/Au(I) Complexes Containing Bidentate N-Heterocyclic Carbenes

(2018) Andrés Luengo et al.   ORGANOMETALLICS

Trackable Metallodrugs Combining Luminescent Re(I) and Bioactive Au(I) Fragments

(2017) Andrés Luengo et al.   INORGANIC CHEMISTRY

Development of rhenacarborane complexes as central nervous system (CNS) drug delivery agents

(2017) Daniel G. Pruitt et al.   INORGANICA CHIMICA ACTA

Self-assembly of manganese(I) and rhenium(I) based semi-rigid ester functionalized M 2 L 2 -type metallacyclophanes: Synthesis, characterization and cytotoxicity evaluation

(2017) Chowan Ashok Kumar et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes

(2017) Kevin M. Knopf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unprecedented anticancer activities of organorhenium sulfonato and carboxylato complexes against hormone-dependent MCF-7 and hormone-independent triple-negative MDA-MB-231 breast cancer cells

(2017) Paul T. Wilder et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Self-Assembly of Chalcogenolato-Bridged Ester and Amide Functionalized Dinuclear Re(I) Metallacycles: Synthesis, Structural Characterization and Preliminary Cytotoxicity Studies

(2017) Muthuraman Karthikeyan et al.   ChemistrySelect

Organometallic Rhenium Complexes Divert Doxorubicin to the Mitochondria

(2016) Sebastian Imstepf et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dose Effect of Rhenium (I)-diselenoether as Anticancer Drug in Resistant Breast Tumor-bearing Mice After Repeated Administrations

(2016) PHILIPPE COLLERY et al.   ANTICANCER RESEARCH

Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes

(2016) Hagir B. Suliman et al.   ANTIOXIDANTS & REDOX SIGNALING

Antimicrobial Properties of Mono- and Di-fac-rhenium Tricarbonyl 2-Pyridyl-1,2,3-triazole Complexes

(2016) Sreedhar V. Kumar et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Mono- and Dinuclear Phosphorescent Rhenium(I) Complexes: Impact of Subcellular Localization on Anticancer Mechanisms

(2016) Rui-Rong Ye et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Nitrosamine-{cis-Re[CO]2}2+ cobalamin conjugates as mixed CO/NO-releasing molecules

(2016) Giuseppe Santoro et al.   DALTON TRANSACTIONS

Capturing Re(i) in an neutral N,N,N pincer Scaffold and resulting enhanced absorption of visible light

(2016) Philip Bulsink et al.   DALTON TRANSACTIONS

Antimicrobial Resistance

(2016) Hilary D. Marston et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Synthesis, characterization and biological evaluation of 99m Tc/Re–tricarbonyl quinolone complexes

(2016) Theocharis E. Kydonaki et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis, characterization and biological activity of Cu(II), Zn(II) and Re(I) complexes derived from S-benzyldithiocarbazate and 3-acetylcoumarin

(2015) May Lee Low et al.   BIOMETALS

Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates

(2015) Giuliana Mion et al.   ChemMedChem

Self-assembly of oxamidato bridged ester functionalised dirhenium metallastirrups: synthesis, characterisation and cytotoxicity studies

(2015) Buthanapalli Ramakrishna et al.   DALTON TRANSACTIONS

Synthesis, characterization and cellular location of cytotoxic constitutional organometallic isomers of rhenium delivered on a cyanocobalmin scaffold

(2015) Giuseppe Santoro et al.   DALTON TRANSACTIONS

Towards Cardiolite-Inspired Carbon Monoxide Releasing Molecules - Reactivity of d4, d5Rhenium and d6Manganese Carb­onyl Complexes with Isocyanide Ligands

(2015) Emmanuel Kottelat et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Non-photochemical synthesis of Re(diimine)(CO) 2 (L)Cl (L = phosphine or phosphite) compounds

(2015) Daniel A. Kurtz et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer

(2015) Philippe Collery et al.   INVESTIGATIONAL NEW DRUGS

Synthesis and functionalization of nitrosyl rhenacarboranes towards their use as drug delivery vehicles

(2015) Daniel G. Pruitt et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

An organometallic structure-activity relationship study reveals the essential role of a Re(CO)3 moiety in the activity against gram-positive pathogens including MRSA

(2015) Malay Patra et al.   Chemical Science

Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents

(2014) Anna Leonidova et al.   ACS Chemical Biology

Influence of the Side-Chain Length on the Cellular Uptake and the Cytotoxicity of Rhenium Triscarbonyl Derivatives: A Bimodal Infrared and Luminescence Quantitative Study

(2014) Sylvain Clède et al.   CHEMISTRY-A EUROPEAN JOURNAL

Towards Matched Pairs of Porphyrin-ReI/99mTcIConjugates that Combine Photodynamic Activity with Fluorescence and Radio Imaging

(2014) Teresa Gianferrara et al.   ChemMedChem

Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum(ii) and rhenium(i) with a ligand targeting the translocator protein (TSPO)

(2014) Nicola Margiotta et al.   DALTON TRANSACTIONS

Synthesis, Characterization, and Photophysical Study of Luminescent Rhenium(I) Diimine Complexes with Various Types of N-Heterocyclic Carbene Ligands

(2014) Chi-On Ng et al.   INORGANIC CHEMISTRY

Synthesis, structure, and reactivity of (η5:η1-C5Me4(CH2)2NMe2)Re(CO)2. Electron transfer behavior of a nitrosyl derivative

(2014) Fernando Godoy et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Synthesis, characterisation and cytotoxicity evaluation of rhenium(I) based ester functionalised dinuclear metallacyclophanes

(2014) Chowan Ashok Kumar et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Guanidine-Functionalized Rhenium Cyclopentadienyl Carbonyl Complexes: Synthesis and Cooperative Activation of H–H and O–H Bonds

(2014) Thomas S. Teets et al.   ORGANOMETALLICS

Synthesis, Dynamics, and DFT Studies of Rhenium Dicarbonyl PNN Pincer Complexes in Three Different Oxidation States

(2014) Kothanda Rama Pichaandi et al.   ORGANOMETALLICS

[Re(CO)3]+ Complexes of exo-Functionalized Tridentate “Click” Macrocycles: Synthesis, Stability, Photophysical Properties, Bioconjugation, and Antibacterial Activity

(2014) Asif Noor et al.   ORGANOMETALLICS

Luminescent Re(i) and Re(i)/Au(i) complexes as cooperative partners in cell imaging and cancer therapy

(2014) Vanesa Fernández-Moreira et al.   Chemical Science

Analysis of the Mechanism of Action of Potent Antibacterial Hetero-tri-organometallic Compounds: A Structurally New Class of Antibiotics

(2013) Michaela Wenzel et al.   ACS Chemical Biology

[(μ-C){Re(CO)2(η-C5H5)}2]: A Surprisingly Simple Bimetallic Carbido Complex

(2013) Rowan D. Young et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A new class of highly solvatochromic dicyano rhenate(i) diimine complexes – synthesis, photophysics and photocatalysis

(2013) Larry Tso-Lun Lo et al.   CHEMICAL COMMUNICATIONS

Solid-State Thermolysis of afac-Rhenium(I) Carbonyl Complex with a Redox Non-Innocent Pincer Ligand

(2013) Titel Jurca et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis, spectroscopic, electrochemical and computational studies of rhenium(i) dicarbonyl complexes based on meridionally-coordinated 2,2′:6′,2′′-terpyridine

(2013) Blaise A. Frenzel et al.   DALTON TRANSACTIONS

pH luminescence switching, dihydrogen phosphate sensing, and cellular uptake of a heterobimetallic ruthenium(ii)–rhenium(i) complex

(2013) Ze-Bao Zheng et al.   DALTON TRANSACTIONS

Towards cancer cell-specific phototoxic organometallic rhenium(i) complexes

(2013) Anna Leonidova et al.   DALTON TRANSACTIONS

A functionalized heterobimetallic99mTc/Re complex as a potential dual-modality imaging probe: synthesis, photophysical properties, cytotoxicity and cellular imaging investigations

(2013) Alison François et al.   DALTON TRANSACTIONS

Rhenium(I) complexes with NNS donor thioarylazoimidazole ligands with the cis-{Re(CO)2}+ core: Synthesis, characterization, electrochemical study and DFT calculation

(2013) Mahendra Sekhar Jana et al.   JOURNAL OF MOLECULAR STRUCTURE

Rhenium and technetium based radiopharmaceuticals: Development and recent advances

(2013) Sophie Jürgens et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Dual Emission from Rhenium(I) Complexes Induced by an Interligand Aromatic Interaction

(2012) Tatsuki Morimoto et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photochemistry offac-[Re(bpy)(CO)3Cl]

(2012) Shunsuke Sato et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biologically Compatible, Phosphorescent Dimetallic Rhenium Complexes Linked through Functionalized Alkyl Chains: Syntheses, Spectroscopic Properties, and Applications in Imaging Microscopy

(2012) Rebeca G. Balasingham et al.   INORGANIC CHEMISTRY

Preparation and characterization of rhenium(I) dicarbonyl complexes based on the meridionally-coordinated terpyridine ligand

(2012) Daniel R. Black et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Luminescent Rhenium(I) Phenanthroline Complexes with a Benzoxazol-2-ylidene Ligand: Synthesis, Characterization, and Photophysical Study

(2012) Chi-Chiu Ko et al.   ORGANOMETALLICS

Transition Metal Based Anticancer Drugs

(2011) K. Benjamin Garbutcheon-Singh et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Reactivity of 17 e− Complex [ReIIBr4(CO)2]2− with Bridging Aromatic Ligands. Characterization and CO-Releasing Properties

(2011) Fabio Zobi et al.   DALTON TRANSACTIONS

17 e−rhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application

(2011) Fabio Zobi et al.   DALTON TRANSACTIONS

CO Releasing Properties and Cytoprotective Effect ofcis-trans- [ReII(CO)2Br2L2]nComplexes

(2010) Fabio Zobi et al.   INORGANIC CHEMISTRY

Ligand Electronic Parameters as a Measure of the Polarization of the C≡O Bond in [M(CO)xLy]nComplexes and of the Relative Stabilization of [M(CO)xLy]n/n+1Species

(2010) Fabio Zobi   INORGANIC CHEMISTRY

Pyridyl-Cyclopentadiene Re(CO)2+Complexes as a Compact Core System for SPECT Ligand Development

(2010) Nathan C. Ackroyd et al.   ORGANOMETALLICS

Parametrization of the Contribution of Mono- and Bidentate Ligands on the Symmetric C≡O Stretching Frequency offac-[Re(CO)3]+Complexes

(2009) Fabio Zobi   INORGANIC CHEMISTRY

Synthesis and Reactivity of the 17 e−Complex [ReIIBr4(CO)2]2−: A Convenient Entry into Rhenium(II) Chemistry

(2009) Fabio Zobi et al.   INORGANIC CHEMISTRY

Substitution reactions with [ReBr2(CO)2(NCCH3)2]−: a convenient route to complexes with the cis-[Re(CO)2]+ core

(2008) Lukas Kromer et al.   DALTON TRANSACTIONS

3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria

(2008) Angelo J. Amoroso et al.   NEW JOURNAL OF CHEMISTRY