Journal
BIOMETALS
Volume 28, Issue 3, Pages 553-566Publisher
SPRINGER
DOI: 10.1007/s10534-015-9831-2
Keywords
3-Acetylcoumarin; S-Benzyldithiocarbazate; Copper(II); Zinc(II); Rhenium(I)
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Funding
- Universiti Putra Malaysia (UPM)
- Ministry of Higher Education (Malaysia)
- French ANR Blanc
- METABACT Grant
- French Infrastructure for Integrated Structural Biology (FRISBI) [ANR-10-INSB-05-01]
- Erasmus Mundus: Maheva Scholarship
- UPM Graduate Research Fellowship (GRF)
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Cu(II), Zn(II) and Re(I) complexes have been synthesized with the Schiff base, N'-[1-(2-oxo-2H-chromen-3-yl)-ethylidene]-hydrazinecarbodithioic acid benzyl ester (SBCM-H) which was prepared by condensation of S-benzyldithiocarbazate and 3-acetylcoumarin. The metal complexes were characterized on the basis of various physico-chemical and spectroscopic techniques including elemental analysis and electrochemical studies, and FT-IR, UV-Vis, NMR, EPR and mass spectroscopy. The Schiff base was found to behave as a bidentate ligand coordinating with Cu(II) and Zn(II) in the thiolate form with 1:2 metal to ligand stoichiometry. Crystals suitable for X-ray diffractometry (XRD) were obtained from the reaction of ReCl(CO)(5) with SBCM-H forming a centrosymmetric dimeric complex Re2L2(CO)(6) linked by Re-S-Re bridges, where S is the thiolate sulfur of the N,S-bidentate ligand. This Re(I) complex is the first metal carbonyl complex with a bidentate dithiocarbazate ligand to have been characterized by XRD. Cytotoxicity assays revealed enhancement of the bioactivity of SBCM-H upon complexation. Both Cu(II) and Re(I) complexes are found to be active against human breast adenocarcinoma cancer cell lines MDA-MB-231 and MCF-7. TOC diagram. [GRAPHICS] .
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