Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide

JAK2 inhibition in JAK2V617F-bearing leukemia cells enriches CD34+ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L

(2020) Jenny Dahlström et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

(2019) Wai Hang Cheng et al.   Alzheimers Research & Therapy

A critical review of melatonin assays: past and present

(2019) David J. Kennaway   JOURNAL OF PINEAL RESEARCH

Interleukin-1β Disturbs the Proliferation and Differentiation of Neural Precursor Cells in the Hippocampus via Activation of Notch Signaling in Postnatal Rats Exposed to Lipopolysaccharide

(2019) Qiongyu Lin et al.   ACS Chemical Neuroscience

Daytime melatonin and light independently affect human alertness and body temperature

(2019) Renske Lok et al.   JOURNAL OF PINEAL RESEARCH

Sleep Disorders in Huntington’s Disease

(2019) Radoslawa Herzog–Krzywoszanska et al.   Frontiers in Psychiatry

Pineal gland dysfunction in Alzheimer’s disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis

(2019) Juhyun Song   Molecular Neurodegeneration

Melatonin Enhances Autophagy and Reduces Apoptosis to Promote Locomotor Recovery in Spinal Cord Injury via the PI3K/AKT/mTOR Signaling Pathway

(2019) Yuanlong Li et al.   NEUROCHEMICAL RESEARCH

Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1

(2019) Sheng-Wei Lai et al.   Nutrients

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury

(2019) Qingxiu Zhang et al.   PLOS BIOLOGY

Melatonin receptor structures shed new light on melatonin research

(2019) Erika Cecon et al.   JOURNAL OF PINEAL RESEARCH

Synaptic structure and alterations in the hippocampus in neonatal rats exposed to lipopolysaccharide

(2019) Lanfen Lin et al.   NEUROSCIENCE LETTERS

Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/β‐catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide

(2019) Peixian Huang et al.   BRAIN PATHOLOGY

Structural biology of telomeres and telomerase

(2019) Eric M. Smith et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gliovascular changes precede white matter damage and long-term disorders in juvenile mild closed head injury

(2018) Beatriz Rodriguez-Grande et al.   GLIA

Molecular Mechanisms of Oligodendrocyte Regeneration in White Matter-Related Diseases

(2018) Ryo Ohtomo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulatory effects of melatonin against rotenone induced rat model of Parkinson's disease

(2018) Zeeshan Rasheed et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

The telomerase enzyme and liver renewal

(2018) Kenneth S. Zaret   NATURE

The Emerging Roles for Telomerase in the Central Nervous System

(2018) Meng-Ying Liu et al.   Frontiers in Molecular Neuroscience

Melatonin Promotes the In Vitro Development of Microinjected Pronuclear Mouse Embryos via Its Anti-Oxidative and Anti-Apoptotic Effects

(2017) Xiuzhi Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia-derived IL-1β contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats

(2017) Qianpeng Han et al.   Journal of Neuroinflammation

Melatonin ameliorates Aβ1-42 -induced Alzheimer's cognitive deficits in mouse model

(2017) Yu-Hang Gong et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Rapid modulation of the silent information regulator 1 by melatonin after hypoxia-ischemia in the neonatal rat brain

(2017) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Melatonin successfully rescues hippocampal bioenergetics and improves cognitive function following drug intoxication by promoting Nrf2-ARE signaling activity

(2017) Li-You Chen et al.   JOURNAL OF PINEAL RESEARCH

Neonatal sepsis

(2017) Andi L Shane et al.   LANCET

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

(2017) Chuan Qin et al.   STROKE

Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion

(2017) Tzu-Hsien Tsai et al.   Oncotarget

Update on melatonin receptors: IUPHAR Review 20

(2016) Ralf Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Repression of telomere-associated genes by microglia activation in neuropsychiatric disease

(2016) Golo Kronenberg et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets

(2016) Erik van Tilborg et al.   PROGRESS IN NEUROBIOLOGY

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

(2015) Divya D. A. Raj et al.   AGING CELL

IL-1β induces hypomyelination in the periventricular white matter through inhibition of oligodendrocyte progenitor cell maturation via FYN/MEK/ERK signaling pathway in septic neonatal rats

(2015) Di Xie et al.   GLIA

The Growing Spectrum of Anti-Inflammatory Interleukins and Their Potential Roles in the Development of Sepsis

(2015) Hong-qiang Zhao et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Role of Telomerase Protein TERT in Alzheimer's Disease and in Tau-Related Pathology In Vitro

(2015) A. Spilsbury et al.   JOURNAL OF NEUROSCIENCE

Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype

(2015) Asif Manzoor Khan et al.   NEUROBIOLOGY OF AGING

Deficiency of Brain ATP-Binding Cassette Transporter A-1 Exacerbates Blood–Brain Barrier and White Matter Damage After Stroke

(2015) Xu Cui et al.   STROKE

Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells

(2015) Jian-Jun Lu et al.   Oncotarget

Anti-Inflammatory Activities of Melatonin Derivatives in Lipopolysaccharide-Stimulated RAW 264.7 Cells and Antinociceptive Effects in Mice

(2014) Chawapon Phiphatwatcharaded et al.   DRUG DEVELOPMENT RESEARCH

Cerebral Palsy and Perinatal Infection in Children Born at Term

(2013) Kristina Ahlin et al.   OBSTETRICS AND GYNECOLOGY

Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B

(2013) Francesca Iannilli et al.   PLoS One

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke

(2010) Bei Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Melatonin protects periventricular white matter from damage due to hypoxia

(2010) C. Kaur et al.   JOURNAL OF PINEAL RESEARCH

Quality of life after septic illness

(2009) Andrea Lazosky et al.   JOURNAL OF CRITICAL CARE

Telomerase Deficiency Affects Normal Brain Functions in Mice

(2009) Jaehoon Lee et al.   NEUROCHEMICAL RESEARCH

Melatonin Promotes Oligodendroglial Maturation of Injured White Matter in Neonatal Rats

(2009) Paul Olivier et al.   PLoS One

Periventricular white matter damage in the hypoxic neonatal brain: Role of microglial cells

(2009) C. Kaur et al.   PROGRESS IN NEUROBIOLOGY

Clinical Prediction of Functional Outcome After Ischemic Stroke

(2008) Brett Kissela et al.   STROKE