Matrine inhibits synovial angiogenesis in collagen-induced arthritis rats by regulating HIF-VEGF-Ang and inhibiting the PI3K/Akt signaling pathway

Matrine: A Promising Natural Product With Various Pharmacological Activities

(2020) Hong Zhang et al.   Frontiers in Pharmacology

GZMB gene silencing confers protection against synovial tissue hyperplasia and articular cartilage tissue injury in rheumatoid arthritis through the MAPK signaling pathway

(2018) Cui-Xia Bao et al.   BIOMEDICINE & PHARMACOTHERAPY

Implications of Angiogenesis Involvement in Arthritis

(2018) Iona MacDonald et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel matrine derivative WM622 inhibits hepatocellular carcinoma by inhibiting PI3K/AKT signaling pathways

(2018) Xiao Sun et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Early Diagnosis and Treatment of Rheumatoid Arthritis

(2018) Emily A. Littlejohn et al.   PRIMARY CARE

Comparative study of anti-VEGF Ranibizumab and interleukin-6 receptor antagonist tocilizumab in adjuvant-induced arthritis

(2018) Amany El-Shahawy Abdel-Maged et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis

(2018) Wanwan Jia et al.   Cell Death & Disease

Anti-Cervical Cancer Role of Matrine, Oxymatrine and Sophora Flavescens Alkaloid Gels and its Mechanism

(2018) Yu Jie Zhou et al.   Journal of Cancer

Rheumatoid arthritis

(2018)   Nature Reviews Disease Primers

The Urokinase Plasminogen Activation System in Rheumatoid Arthritis: Pathophysiological Roles and Prospective Therapeutic Targets

(2018) Benjamin J Buckley et al.   CURRENT DRUG TARGETS

Peroxisome proliferator-activated receptor γ mediates porcine placental angiogenesis through hypoxia inducible factor-, vascular endothelial growth factor- and angiopoietin-mediated signaling

(2017) Juzuo Zhang et al.   Molecular Medicine Reports

Effect of nobiletin on the MAPK/NF-κB signaling pathway in the synovial membrane of rats with arthritis induced by collagen

(2017) Guliang Yang et al.   Food & Function

Inhibition of angiogenesis by arsenic trioxide via TSP-1–TGF-β1-CTGF–VEGF functional module in rheumatoid arthritis

(2017) Juan Zhang et al.   Oncotarget

Glucose-6-Phosphate Isomerase (G6PI) Mediates Hypoxia-Induced Angiogenesis in Rheumatoid Arthritis

(2017) Ying Lu et al.   Scientific Reports

Matrine: Bioactivities and Structural Modifications

(2016) Jiulin Huang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK/STAT signaling pathway

(2016) Yongsheng Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner

(2016) Zhaowen Yang et al.   JOINT BONE SPINE

Anti-angiogenic effect of total saponins of Rhizoma Dioscorea nipponica on collagen induced-arthritis in rats

(2016) Xiu-Jun Liang et al.   Experimental and Therapeutic Medicine

Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis

(2016) Susan Hua et al.   Frontiers in Pharmacology

The pathogenic role of angiogenesis in rheumatoid arthritis

(2015) Hatem A. Elshabrawy et al.   ANGIOGENESIS

HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation

(2015) So Youn Park et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Placental Growth Factor-1 and -2 Induce Hyperplasia and Invasiveness of Primary Rheumatoid Synoviocytes

(2015) Seung-Ah Yoo et al.   JOURNAL OF IMMUNOLOGY

Comparison ofTripterygium wilfordiiHook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial

(2014) Qian-wen Lv et al.   ANNALS OF THE RHEUMATIC DISEASES

Placental growth factor in cancer

(2014) Mieke Dewerchin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Hypoxia-Inducible Factor Pathway, Prolyl Hydroxylase Domain Protein Inhibitors, and Their Roles in Bone Repair and Regeneration

(2014) Lihong Fan et al.   Biomed Research International

Evidence That CXCL16 Is a Potent Mediator of Angiogenesis and Is Involved in Endothelial Progenitor Cell Chemotaxis: Studies in Mice With K/BxN Serum-Induced Arthritis

(2013) Takeo Isozaki et al.   ARTHRITIS AND RHEUMATISM

Torilin ameliorates type II collagen-induced arthritis in mouse model of rheumatoid arthritis

(2013) Mehari Endale et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of tripterygium glycosides on pulmonary function in adjuvant arthritis rats

(2013) Lei Wan et al.   Journal of the Chinese Medical Association

Platelet rich plasma extract promotes angiogenesis through the angiopoietin1-Tie2 pathway

(2013) Tadanori Mammoto et al.   MICROVASCULAR RESEARCH

Taxol: Efficacy Against Oral Squamous Cell Carcinoma

(2013) Kaitlyn Ledwitch et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

(2012) Sofia Konisti et al.   Nature Reviews Rheumatology

Characterization of CCL19 and CCL21 in rheumatoid arthritis

(2011) Sarah R. Pickens et al.   ARTHRITIS AND RHEUMATISM

Tacrolimus (FK506) inhibits interleukin-1β-induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes

(2011) Jung-Yoon Choe et al.   JOINT BONE SPINE

Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192

(2011) Lin Sun et al.   JOURNAL OF PATHOLOGY

New insights in synovial angiogenesis

(2009) Zoltán Szekanecz et al.   JOINT BONE SPINE

Vascular involvement in rheumatic diseases: 'vascular rheumatology'

(2008) Zoltán Szekanecz et al.   ARTHRITIS RESEARCH & THERAPY