The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism

Mtr4 RNA helicase structures and interactions

(2021) Keith J. Olsen et al.   BIOLOGICAL CHEMISTRY

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain

(2021) Nikolay Dobrev et al.   Nature Communications

Mammalian RNA Decay Pathways Are Highly Specialized and Widely Linked to Translation

(2020) Alex Charles Tuck et al.   MOLECULAR CELL

Extraction of mRNA from Stalled Ribosomes by the Ski Complex

(2020) Alexandra Zinoviev et al.   MOLECULAR CELL

Current approaches for automated model building into cryo-EM maps using Buccaneer with CCP-EM

(2020) Soon Wen Hoh et al.   Acta Crystallographica Section D-Structural Biology

RNA helicases are hubs that orchestrate exosome-dependent 3′–5′ decay

(2020) Eva-Maria Weick et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways

(2019) Ken Ikeuchi et al.   EMBO JOURNAL

Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control

(2019) Marie-Luise Winz et al.   Nature Communications

NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction

(2019) Jianshu Wang et al.   GENES & DEVELOPMENT

The tetratricopeptide-repeat motif is a versatile platform that enables diverse modes of molecular recognition

(2019) Albert Perez-Riba et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Software tools for automated transmission electron microscopy

(2019) Martin Schorb et al.   NATURE METHODS

A specialised SKI complex assists the cytoplasmic RNA exosome in the absence of direct association with ribosomes

(2019) Elodie Zhang et al.   EMBO JOURNAL

The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs

(2019) Mahesh Lingaraju et al.   Nature Communications

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

RNA helicases in RNA decay

(2018) Vanessa Khemici et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex

(2018) Eva-Maria Weick et al.   CELL

Structural basis for MTR4–ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex

(2018) M. Rhyan Puno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the nuclear exosome captured on a maturing preribosome

(2018) Jan Michael Schuller et al.   SCIENCE

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Distinct and evolutionary conserved structural features of the human nuclear exosome complex

(2018) Piotr Gerlach et al.   eLife

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

ZNF598 Is a Quality Control Sensor of Collided Ribosomes

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Focus: The interface between data collection and data processing in cryo-EM

(2017) Nikhil Biyani et al.   JOURNAL OF STRUCTURAL BIOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53

(2017) Sebastian Falk et al.   RNA

Novel mutations in SKIV2L and TTC37 genes in Malaysian children with trichohepatoenteric syndrome

(2016) Way Seah Lee et al.   GENE

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Multiple Parallel Pathways of Translation Initiation on the CrPV IRES

(2016) Alexey Petrov et al.   MOLECULAR CELL

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex

(2016) Eva Kowalinski et al.   MOLECULAR CELL

The cryo-EM structure of a ribosome–Ski2-Ski3-Ski8 helicase complex

(2016) Christian Schmidt et al.   SCIENCE

The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins

(2015) Matthias Thoms et al.   CELL

The conformational plasticity of eukaryotic RNA-dependent ATPases

(2015) Sevim Ozgur et al.   FEBS Journal

Structure of the human 80S ribosome

(2015) Heena Khatter et al.   NATURE

Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

(2014) Israel S. Fernández et al.   CELL

The eukaryotic RNA exosome

(2014) Kurt Januszyk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Molecular Architecture of the TRAMP Complex Reveals the Organization and Interplay of Its Two Catalytic Activities

(2014) Sebastian Falk et al.   MOLECULAR CELL

The SKIV2L RNA exosome limits activation of the RIG-I-like receptors

(2014) Sterling C Eckard et al.   NATURE IMMUNOLOGY

RNA decay machines: The exosome

(2013) Aleksander Chlebowski et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Yeast Ski Complex: Crystal Structure and RNA Channeling to the Exosome Complex

(2013) Felix Halbach et al.   CELL

Syndromic diarrhea/Tricho-hepato-enteric syndrome

(2013) Alexandre Fabre et al.   Orphanet Journal of Rare Diseases

piggyBac transposase tools for genome engineering

(2013) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SKIV2L Mutations Cause Syndromic Diarrhea, or Trichohepatoenteric Syndrome

(2012) Alexandre Fabre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Different nuclease requirements for exosome-mediated degradation of normal and nonstop mRNAs

(2011) D. Schaeffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of S. cerevisiae Ski2, a DExH helicase associated with the cytoplasmic functions of the exosome

(2011) F. Halbach et al.   RNA

MultiBac: expanding the research toolbox for multiprotein complexes

(2011) Christoph Bieniossek et al.   TRENDS IN BIOCHEMICAL SCIENCES

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Unique Properties of the Mtr4p−Poly(A) Complex Suggest a Role in Substrate Targeting

(2010) Jade Bernstein et al.   BIOCHEMISTRY

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

(2010) Rafal Tomecki et al.   EMBO JOURNAL

The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing

(2010) Ryan N Jackson et al.   EMBO JOURNAL

Novel mutations in TTC37 associated with tricho-hepato-enteric syndrome

(2010) Alexandre Fabre et al.   HUMAN MUTATION

Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance

(2010) J. R. Weir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WD40 proteins propel cellular networks

(2010) Christian U. Stirnimann et al.   TRENDS IN BIOCHEMICAL SCIENCES

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

IRES-induced conformational changes in the ribosome and the mechanism of translation initiation by internal ribosomal entry

(2009) Christopher U.T. Hellen   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation

(2009) Fabien Bonneau et al.   CELL