Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells

Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation

(2021) Marco Igor Valencia-Sánchez et al.   SCIENCE

Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets

(2020) Arnaldo Henrique de Souza et al.   Scientific Reports

Epigenetic Changes During Human Thyroid Cell Differentiation

(2020) Risheng Ma et al.   THYROID

Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate

(2020) Cecilia Pessoa Rodrigues et al.   Science Advances

Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

(2020) Le Tran Phuc Khoa et al.   Cell Stem Cell

Mof regulates glucose level via altering different α-cell subset mass and intra-islet glucagon-like peptide-1, glucagon secretion

(2020) Xinghong Guo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Histone acetyl transferase MOF orchestrates outcomes at the crossroad of oncogenesis, DNA damage response, proliferation, and stem cell development

(2020) Mayank Singh et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein restriction during pregnancy impairs intra-islet GLP-1 and the expansion of β-cell mass

(2020) Edson Henrique Pereira de Arruda et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature

(2020) Bilal N. Sheikh et al.   NATURE CELL BIOLOGY

Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice

(2020) Shan Lang et al.   PEPTIDES

MOF Regulates TNK2 Transcription Expression to Promote Cell Proliferation in Thyroid Cancer

(2020) Danyang Li et al.   Frontiers in Pharmacology

Glucagon Receptor Antagonist Stimulated α-Cell Proliferation is Severely Restricted with Advanced Age

(2019) Carol J. Lam et al.   DIABETES

The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function

(2019) Ruth A. Singer et al.   Cell Metabolism

A crosstalk between BRG1 and MOF contributes to ROS production in a mouse model of non-alcoholic steatohepatitis

(2018) Li Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production

(2018) Li Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice

(2018) Takao Nammo et al.   DIABETOLOGIA

The α-cell in diabetes mellitus

(2018) Jesper Gromada et al.   Nature Reviews Endocrinology

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion

(2017) Nadejda Bozadjieva et al.   JOURNAL OF CLINICAL INVESTIGATION

Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling

(2017) Lingshu Wang et al.   Stem Cell Research & Therapy

Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis

(2017) Shuyang Traub et al.   Cell Reports

MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria

(2016) Aindrila Chatterjee et al.   CELL

Inhibiting or antagonizing glucagon: making progress in diabetes care

(2015) P. J. Lefèbvre et al.   DIABETES OBESITY & METABOLISM

Protein acetylation in metabolism — metabolites and cofactors

(2015) Keir J. Menzies et al.   Nature Reviews Endocrinology

Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease

(2015) Darleen A. Sandoval et al.   PHYSIOLOGICAL REVIEWS

H2B Ubiquitylation Promotes RNA Pol II Processivity via PAF1 and pTEFb

(2014) Lipeng Wu et al.   MOLECULAR CELL

Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation

(2014) Sarina Ravens et al.   eLife

Crosstalk between NSL Histone Acetyltransferase and MLL/SET Complexes: NSL Complex Functions in Promoting Histone H3K4 Di-Methylation Activity by MLL/SET Complexes

(2013) Xiaoming Zhao et al.   PLoS Genetics

The Histone Acetyltransferase MOF Is a Key Regulator of the Embryonic Stem Cell Core Transcriptional Network

(2012) Xiangzhi Li et al.   Cell Stem Cell

Glucagon antagonism as a potential therapeutic target in type 2 diabetes

(2011) J. I. Bagger et al.   DIABETES OBESITY & METABOLISM

Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice

(2011) J. Mu et al.   DIABETOLOGIA

Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival

(2011) Z. Liu et al.   DIABETOLOGIA

Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?

(2011) N M Whalley et al.   JOURNAL OF ENDOCRINOLOGY

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(2011) Dan Christensen et al.   MOLECULAR MEDICINE

Pax6 Controls the Expression of Critical Genes Involved in Pancreatic α Cell Differentiation and Function

(2010) Yvan Gosmain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transplantation of PC1/3-Expressing α-cells Improves Glucose Handling and Cold Tolerance in Leptin-resistant Mice

(2008) Rhonda D Wideman et al.   MOLECULAR THERAPY