Brown adipose tissue transplantation ameliorates diabetic nephropathy through the miR-30b pathway by targeting Runx1

Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

(2020) Jèssica Latorre et al.   EBioMedicine

Transplantation of brown adipose tissue up-regulates miR-99a to ameliorate liver metabolic disorders in diabetic mice by targeting NOX4

(2020) Ping Li et al.   Adipocyte

IDH1-dependent α-KG regulates brown fat differentiation and function by modulating histone methylation

(2020) Hyun Sup Kang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy

(2020) Huijie Guo et al.   CELL DEATH AND DIFFERENTIATION

UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice

(2020) Yuko Okamatsu-Ogura et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Renoprotective effects of brown adipose tissue activation in diabetic mice

(2019) Ying‐Ying Cai et al.   Journal of Diabetes

RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer

(2019) Qingyuan Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Differential Expression of Urinary Exosomal MicroRNAs miR-21-5p and miR-30b-5p in Individuals with Diabetic Kidney Disease

(2019) Jinnan Zang et al.   Scientific Reports

Captopril and Spironolactone Can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting microRNA-192 and microRNA-29a/b/c

(2019) Zahra Ebadi et al.   DNA AND CELL BIOLOGY

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney

(2019) Swayam Prakash Srivastava et al.   Frontiers in Pharmacology

PGRMC2 is an intracellular haem chaperone critical for adipocyte function

(2019) Andrea Galmozzi et al.   NATURE

Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease

(2018) Yue Wang et al.   Journal of Translational Medicine

Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy

(2018) Sun Ryoung Choi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes

(2018) Pascal Gottmann et al.   Molecular Metabolism

Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ

(2018) Tong Zhou et al.   EBioMedicine

MiR-30b-5p functions as a tumor suppressor in cell proliferation, metastasis and epithelial-to-mesenchymal transition by targeting G-protein subunit α-13 in renal cell carcinoma

(2017) Wenjuan Liu et al.   GENE

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Kidney disease and obesity: epidemiology, mechanisms and treatment

(2017) Niels Olsen Saraiva Câmara et al.   Nature Reviews Nephrology

MicroRNA-27a promotes podocyte injury via PPARγ-mediated β-catenin activation in diabetic nephropathy

(2017) Zhanmei Zhou et al.   Cell Death & Disease

Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition

(2017) Deli Hong et al.   Oncotarget

MicroRNA-30b Suppresses Epithelial-Mesenchymal Transition and Metastasis of Hepatoma Cells

(2016) Xiaolin Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Brown adipose tissue as a secretory organ

(2016) Francesc Villarroya et al.   Nature Reviews Endocrinology

Brown adipose tissue transplantation ameliorates polycystic ovary syndrome

(2016) Xiaoxue Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation

(2015) Mir Farshid Alemdehy et al.   BLOOD

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140

(2015) Fang Hu et al.   DIABETES

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

(2015) Jay C. Jha et al.   DIABETOLOGIA

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1  signaling network

(2015) H. Zhang et al.   EMBO REPORTS

Elevation of miR-27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells

(2015) SHIMENG ZHANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria

(2015) C. H. Lee et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia

(2015) John Fischer et al.   Molecular Cancer

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Urinary MicroRNA Profiling Predicts the Development of Microalbuminuria in Patients with Type 1 Diabetes

(2015) Christos Argyropoulos et al.   Journal of Clinical Medicine

Fibroblast Growth Factor 21 Improves Insulin Resistance and Ameliorates Renal Injury indb/dbMice

(2013) H. W. Kim et al.   ENDOCRINOLOGY

Increased Mitochondrial Activity in BMP7-Treated Brown Adipocytes, Due to Increased CPT1- and CD36-Mediated Fatty Acid Uptake

(2012) Kristy L. Townsend et al.   ANTIOXIDANTS & REDOX SIGNALING

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis

(2012) Keun Hur et al.   GUT

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma adiponectin is related to the progression of kidney disease in type 2 diabetes patients

(2012) Ina Maria Kacso et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1

(2011) Jingcheng Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

(2011) Michela Garofalo et al.   NATURE MEDICINE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adiponectin stimulates phosphorylation of AMP-activated protein kinase α in renal glomeruli

(2008) Philippe G. Cammisotto et al.   JOURNAL OF MOLECULAR HISTOLOGY

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists

(2008) Jonathan R. S. Arch   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY